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Sebastian Pomplun
Sebastian Pomplun
Associate Professor Leiden University LACDR
在 lacdr.leidenuniv.nl 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
The first-in-class peptide binder to the SARS-CoV-2 spike protein
G Zhang, S Pomplun, AR Loftis, A Loas, BL Pentelute
BioRxiv 10 (2020.03), 19.999318, 2020
1152020
Investigation of ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD
G Zhang, S Pomplun, AR Loftis, X Tan, A Loas, BL Pentelute
BioRxiv, 2020.03. 19.999318, 2020
902020
De Novo Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein
S Pomplun, M Jbara, AJ Quartararo, G Zhang, JS Brown, YC Lee, X Ye, ...
ACS central science 7 (1), 156-163, 2020
782020
Chemogenomic profiling of human and microbial FK506-binding proteins
S Pomplun, C Sippel, A Hähle, D Tay, K Shima, A Klages, CM Ünal, ...
Journal of medicinal chemistry 61 (8), 3660-3673, 2018
642018
Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506‐Binding Proteins (FKBPs)
S Pomplun, Y Wang, A Kirschner, C Kozany, A Bracher, F Hausch
Angewandte Chemie International Edition 54 (1), 345-348, 2015
412015
Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides
S Pomplun
RSC Medicinal Chemistry 12 (2), 197-202, 2021
392021
Engineering bioactive dimeric transcription factor analogs via palladium rebound reagents
M Jbara, S Pomplun, CK Schissel, SW Hawken, A Boija, I Klein, ...
Journal of the American Chemical Society 143 (30), 11788-11798, 2021
312021
Recent progress in FKBP ligand development
X Feng, S Pomplun, F Hausch
Current molecular pharmacology 9 (1), 27-36, 2016
272016
Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3. 1] aza-amides
JM Kolos, S Pomplun, S Jung, B Rieß, PL Purder, AM Voll, S Merz, ...
Chemical science 12 (44), 14758-14765, 2021
262021
Loratadine and Analogues: Discovery and Preliminary Structure–Activity Relationship of Inhibitors of the Amino Acid Transporter B0AT2
S Cuboni, C Devigny, B Hoogeland, A Strasser, S Pomplun, B Hauger, ...
Journal of medicinal chemistry 57 (22), 9473-9479, 2014
262014
Discovery of nucleic acid binding molecules from combinatorial biohybrid nucleobase peptide libraries
S Pomplun, ZP Gates, G Zhang, AJ Quartararo, BL Pentelute
Journal of the American Chemical Society 142 (46), 19642-19651, 2020
252020
Efficient Pictet–Spengler Bioconjugation with N‐Substituted Pyrrolyl Alanine Derivatives
S Pomplun, MYH Mohamed, T Oelschlaegel, C Wellner, F Bergmann
Angewandte Chemie 131 (11), 3580-3585, 2019
232019
Parallel automated flow synthesis of covalent protein complexes that can inhibit MYC-driven transcription
S Pomplun, M Jbara, CK Schissel, S Wilson Hawken, A Boija, C Li, I Klein, ...
ACS Central Science 7 (8), 1408-1418, 2021
222021
Secondary amino alcohols: traceless cleavable linkers for use in affinity capture and release
S Pomplun, CR Shugrue, AM Schmitt, CK Schissel, CE Farquhar, ...
Angewandte Chemie International Edition 59 (28), 11566-11572, 2020
122020
Advances in ultrahigh throughput hit discovery with tandem mass spectrometry encoded libraries
JM Mata, E van der Nol, SJ Pomplun
Journal of the American Chemical Society 145 (34), 19129-19139, 2023
72023
Rationales Design und asymmetrische Synthese potenter neuritotropher Liganden für FK506‐bindende Proteine (FKBPs)
S Pomplun, Y Wang, A Kirschner, C Kozany, A Bracher, F Hausch
Angewandte Chemie 127 (1), 352-355, 2015
52015
Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids
BD Ellenbroek, JP Kahler, SR Evers, SJ Pomplun
Angewandte Chemie International Edition 63 (20), e202401704, 2024
32024
Automated flow peptide synthesis enables engineering of proteins with stabilized transient binding pockets
A Charalampidou, T Nehls, C Meyners, S Gandhesiri, S Pomplun, ...
ACS Central Science 10 (3), 649-657, 2024
12024
Use of DNA forceps to measure receptor-ligand dissociation equilibrium constants in a single-molecule competition assay.
F Stransky, D Kostrz, M Follenfant, S Pomplun, C Meyners, T Strick, ...
Methods in Enzymology 694, 51-82, 2024
12024
Development of DuoMYC: a synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC
S Pomplun, B Ellenbroek, JP Kahler, D Arella, C Lin, W Jespers
bioRxiv, 2024.03. 04.583305, 2024
12024
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