| Insights into antifolate resistance from malarial DHFR-TS structures J Yuvaniyama, P Chitnumsub, S Kamchonwongpaisan, J Vanichtanankul, ... Nature Structural & Molecular Biology 10 (5), 357-365, 2003 | 486 | 2003 |
| Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target Y Yuthavong, B Tarnchompoo, T Vilaivan, P Chitnumsub, ... Proceedings of the National Academy of Sciences 109 (42), 16823-16828, 2012 | 296 | 2012 |
| Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs R Li, R Sirawaraporn, P Chitnumsub, W Sirawaraporn, J Wooden, ... Journal of molecular biology 295 (2), 307-323, 2000 | 254 | 2000 |
| Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: structural basis for antifolate resistance and development of effective inhibitors Y Yuthavong, J Yuvaniyama, P Chitnumsub, J Vanichtanankul, ... Parasitology 130 (3), 249-259, 2005 | 128 | 2005 |
| Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance P Kongsaeree, P Khongsuk, U Leartsakulpanich, P Chitnumsub, ... Proceedings of the National Academy of Sciences 102 (37), 13046-13051, 2005 | 103 | 2005 |
| The nucleation of monomeric parallel β-sheet-like structures and their self-assembly in aqueous solution P Chitnumsub, WR Fiori, HA Lashuel, H Diaz, JW Kelly Bioorganic & medicinal chemistry 7 (1), 39-59, 1999 | 95 | 1999 |
| Exploiting Structural Analysis, in Silico Screening, and Serendipity To Identify Novel Inhibitors of Drug-Resistant Falciparum Malaria T Dasgupta, P Chitnumsub, S Kamchonwongpaisan, ... ACS chemical biology 4 (1), 29-40, 2009 | 75 | 2009 |
| Mechanism-guided tunnel engineering to increase the efficiency of a flavin-dependent halogenase K Prakinee, A Phintha, S Visitsatthawong, N Lawan, J Sucharitakul, ... Nature Catalysis 5 (6), 534-544, 2022 | 68 | 2022 |
| Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood-and liver-stage activities MC Witschel, M Rottmann, A Schwab, U Leartsakulpanich, P Chitnumsub, ... Journal of medicinal chemistry 58 (7), 3117-3130, 2015 | 68 | 2015 |
| Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites A Sardarian, KT Douglas, M Read, PFG Sims, JE Hyde, P Chitnumsub, ... Organic & biomolecular chemistry 1 (6), 960-964, 2003 | 63 | 2003 |
| Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase–thymidylate synthase from Plasmodium falciparum P Chitnumsub, J Yavaniyama, J Vanichtanankul, S Kamchonwongpaisan, ... Acta Crystallographica Section D: Biological Crystallography 60 (4), 780-783, 2004 | 60 | 2004 |
| Trypanosomal dihydrofolate reductase reveals natural antifolate resistance J Vanichtanankul, S Taweechai, J Yuvaniyama, T Vilaivan, P Chitnumsub, ... ACS chemical biology 6 (9), 905-911, 2011 | 59 | 2011 |
| Folate metabolism as a source of molecular targets for antimalarials Y Yuthavong, S Kamchonwongpaisan, U Leartsakulpanich, ... Future Microbiology 1 (1), 113-125, 2006 | 56 | 2006 |
| Antimalarial inhibitors targeting serine hydroxymethyltransferase (SHMT) with in vivo efficacy and analysis of their binding mode based on X-ray cocrystal structures G Schwertz, MC Witschel, M Rottmann, R Bonnert, U Leartsakulpanich, ... Journal of medicinal chemistry 60 (12), 4840-4860, 2017 | 48 | 2017 |
| Avian influenza A/H5N1 neuraminidase expressed in yeast with a functional head domain S Yongkiettrakul, K Boonyapakron, A Jongkaewwattana, A Wanitchang, ... Journal of virological methods 156 (1-2), 44-51, 2009 | 43 | 2009 |
| Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil J Vanichtanankul, S Taweechai, C Uttamapinant, P Chitnumsub, ... Antimicrobial agents and chemotherapy 56 (7), 3928-3935, 2012 | 41 | 2012 |
| Dissecting the low catalytic capability of flavin-dependent halogenases A Phintha, K Prakinee, A Jaruwat, N Lawan, S Visitsatthawong, ... Journal of Biological Chemistry 296, 2021 | 37 | 2021 |
| Structure-based protein engineering for thermostable and alkaliphilic enhancement of endo-β-1, 4-xylanase for applications in pulp bleaching K Boonyapakron, A Jaruwat, B Liwnaree, T Nimchua, V Champreda, ... Journal of biotechnology 259, 95-102, 2017 | 35 | 2017 |
| Identification of a hotspot residue for improving the thermostability of a flavin‐dependent monooxygenase P Pongpamorn, P Watthaisong, P Pimviriyakul, A Jaruwat, N Lawan, ... ChemBioChem 20 (24), 3020-3031, 2019 | 33 | 2019 |
| Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N′6′-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate A Nzila, M Rottmann, P Chitnumsub, SM Kiara, S Kamchonwongpaisan, ... Antimicrobial agents and chemotherapy 54 (6), 2603-2610, 2010 | 30 | 2010 |
