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Tessa R. Young
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The requirement for cobalt in vitamin B12: A paradigm for protein metalation
D Osman, A Cooke, TR Young, E Deery, NJ Robinson, MJ Warren
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 118896, 2020
1272020
An integrated study of the affinities of the Aβ16 peptide for Cu (I) and Cu (II): implications for the catalytic production of reactive oxygen species
TR Young, A Kirchner, AG Wedd, Z Xiao
Metallomics 6 (3), 505-517, 2014
732014
Protein metalation in biology
AW Foster, TR Young, PT Chivers, NJ Robinson
Current Opinion in Chemical Biology 66, 102095, 2022
622022
Copper binding and redox chemistry of the Aβ16 peptide and its variants: insights into determinants of copper-dependent reactivity
N Yako, TR Young, JMC Jones, CA Hutton, AG Wedd, Z Xiao
Metallomics 9 (3), 278-291, 2017
472017
Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII
TR Young, MA Martini, AW Foster, A Glasfeld, D Osman, RJ Morton, ...
Nature Communications 12 (1), 1195, 2021
452021
Principles and practice of determining metal–protein affinities
TR Young, Z Xiao
Biochemical Journal 478 (5), 1085-1116, 2021
342021
CopC Protein from Pseudomonas fluorescens SBW25 Features a Conserved Novel High-Affinity Cu(II) Binding Site
CJK Wijekoon, TR Young, AG Wedd, Z Xiao
Inorganic chemistry 54 (6), 2950-2959, 2015
332015
A set of robust fluorescent peptide probes for quantification of Cu (II) binding affinities in the micromolar to femtomolar range
TR Young, CJK Wijekoon, B Spyrou, PS Donnelly, AG Wedd, Z Xiao
Metallomics 7 (3), 567-578, 2015
332015
Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function
SL Leong, TR Young, KJ Barnham, AG Wedd, MG Hinds, Z Xiao, ...
Metallomics 6 (1), 105-116, 2014
232014
Evaluation of Cu (i) binding to the E2 domain of the amyloid precursor protein–a lesson in quantification of metal binding to proteins via ligand competition
TR Young, AG Wedd, Z Xiao
Metallomics 10 (1), 108-119, 2018
222018
Acquisition of ionic copper by the bacterial outer membrane protein OprC through a novel binding site
SP Bhamidimarri, TR Young, M Shanmugam, S Soderholm, A Baslé, ...
PLoS biology 19 (11), e3001446, 2021
212021
The Human Amyloid Precursor Protein Binds Copper Ions Dominated by a Picomolar-Affinity Site in the Helix-Rich E2 Domain
TR Young, TL Pukala, R Cappai, AG Wedd, Z Xiao
Biochemistry 57 (28), 4165-4176, 2018
202018
Metalation calculators for E. coli strain JM109 (DE3): aerobic, anaerobic, and hydrogen peroxide exposed cells cultured in LB media
AW Foster, SE Clough, Z Aki, TR Young, AR Clarke, NJ Robinson
Metallomics 14 (9), mfac058, 2022
182022
Insights into the antibacterial mechanism of action of chelating agents by selective deprivation of iron, manganese and zinc
JR Paterson, MS Beecroft, RS Mulla, D Osman, NL Reeder, JA Caserta, ...
Applied and Environmental Microbiology, AEM. 01641-21, 2021
162021
Two Distinct Thermodynamic Gradients for Cellular Metalation of Vitamin B12
TR Young, E Deery, AW Foster, MA Martini, D Osman, MJ Warren, ...
JACS Au 3 (5), 1472-1483, 2023
52023
Acquisition of ionic copper by a bacterial outer membrane protein
SP Bhamidimarri, TR Young, M Shanmugam, S Soderholm, A Baslé, ...
bioRxiv, 2020.06. 04.134395, 2020
32020
Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis upon binding nucleotide
TR Young, MA Martini, D Osman, RJ Morton, E Deery, MJ Warren, ...
BioRxiv, 2020.06. 26.173062, 2020
22020
Hyperaerated metalation calculator for E. coli strain JM109 (DE3) grown in LB media
SE Clough, D Osman, TR Young, NJ Robinson
bioRxiv, 2022.09. 02.506343, 2022
2022
Molecular Characterisation of the Amyloid Precursor Protein
TR Young
2017
Conference Theme: Molecular Imaging-Multiple Modalities
Z Xiao, TR Young, AG Wedd
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