Discovery of cyclic boronic acid QPX7728, an ultrabroad-spectrum inhibitor of serine and metallo-β-lactamases SJ Hecker, KR Reddy, O Lomovskaya, DC Griffith, D Rubio-Aparicio, ... Journal of medicinal chemistry 63 (14), 7491-7507, 2020 | 172 | 2020 |
Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor S Balderston, JJ Taulbee, E Celaya, K Fung, A Jiao, K Smith, R Hajian, ... Nature Biomedical Engineering 5 (7), 713-725, 2021 | 101 | 2021 |
Activity of Simulated Human Dosage Regimens of Meropenem and Vaborbactam against Carbapenem-Resistant Enterobacteriaceae in an In Vitro Hollow-Fiber … M Sabet, Z Tarazi, D Rubio-Aparicio, TG Nolan, J Parkinson, ... Antimicrobial agents and chemotherapy 62 (2), 10.1128/aac. 01969-17, 2018 | 41 | 2018 |
Activity of meropenem-vaborbactam in mouse models of infection due to KPC-producing carbapenem-resistant Enterobacteriaceae M Sabet, Z Tarazi, T Nolan, J Parkinson, D Rubio-Aparicio, ... Antimicrobial Agents and Chemotherapy 62 (1), 10.1128/aac. 01446-17, 2018 | 33 | 2018 |
The promise of graphene-based transistors for democratizing multiomics studies HW Lu, AA Kane, J Parkinson, Y Gao, R Hajian, M Heltzen, B Goldsmith, ... Biosensors and Bioelectronics 195, 113605, 2022 | 32 | 2022 |
Rapid and Electronic Identification and Quantification of Age‐Specific Circulating Exosomes via Biologically Activated Graphene Transistors R Hajian, J DeCastro, J Parkinson, A Kane, AFR Camelo, PP Chou, ... Advanced Biology 5 (7), 2000594, 2021 | 22 | 2021 |
The RESP AI model accelerates the identification of tight-binding antibodies J Parkinson, R Hard, W Wang Nature communications 14 (1), 454, 2023 | 17 | 2023 |
Selection of QPX7831, an orally bioavailable prodrug of boronic acid β-lactamase inhibitor QPX7728 KR Reddy, J Parkinson, M Sabet, Z Tarazi, SH Boyer, O Lomovskaya, ... Journal of Medicinal Chemistry 64 (23), 17523-17529, 2021 | 14 | 2021 |
Engineering a histone reader protein by combining directed evolution, sequencing, and neural network based ordinal regression J Parkinson, R Hard, RI Ainsworth, N Li, W Wang Journal of Chemical Information and Modeling 60 (8), 3992-4004, 2020 | 12 | 2020 |
In vivo efficacy of Carbavance (meropenem/RPX7009) against KPC-producing Enterobacteriaceae M Sabet, Z Tarazi, T Nolan, J Parkinson, D Rubio-Aparicio, ... 54th Interscience Conference on Antimicrobial Agents and Chemotherapy …, 2014 | 11 | 2014 |
Efficacy of simulated human exposures of Carbavance (meropenem-RPX7009) against carbapenem-resistant Enterobacteriaceae in an in vitro hollow fiber model, abstr F-959 Z Tarazi, M Sabet, D Rubio-Aparicio, T Nolan, J Parkinson, ... Intersci Conf Antimicrob Agents Chemother, Washington, DC 5, 2014 | 10 | 2014 |
Linear-Scaling kernels for protein sequences and small molecules outperform deep learning while providing uncertainty quantitation and improved interpretability J Parkinson, W Wang Journal of Chemical Information and Modeling 63 (15), 4589-4601, 2023 | 7* | 2023 |
Pharmacology of the novel polymyxin Faddi-287 in preclinical models M Sabet, Z Tarazi, T Nolan, J Parkinson, D Rubio-Aparicio, KD Roberts, ... Poster at the Saturday-499. ASM Microbe,(Boston, MA), 2016 | 7 | 2016 |
Machine learning for disease classification: A perspective J Parkinson, JH DeCastro, B Goldsmith, K Aran Artificial Intelligence in Healthcare and Medicine, 1-27, 2022 | 2 | 2022 |
For antibody sequence generative modeling, mixture models may be all you need J Parkinson, W Wang Bioinformatics 40 (5), btae278, 2024 | | 2024 |
TUnA: An uncertainty aware transformer model for sequence-based protein-protein interaction prediction YS Ko, J Parkinson, C Liu, W Wang bioRxiv, 2024.02. 19.581072, 2024 | | 2024 |
Scalable apparatuses and models for determining analytically efficient transfer curve parameters for sensor ics with 2d field effect transistors B Goldsmith, J Parkinson, K Aran, A Kane US Patent App. 18/319,347, 2023 | | 2023 |
Engineering human JMJD2A tudor domains for an improved understanding of histone peptide recognition J Parkinson, R Hard, R Ainsworth, W Wang Proteins: Structure, Function, and Bioinformatics 91 (1), 32-46, 2023 | | 2023 |