A structured tumor-immune microenvironment in triple negative breast cancer revealed by multiplexed ion beam imaging L Keren, M Bosse, D Marquez, R Angoshtari, S Jain, S Varma, SR Yang, ... Cell 174 (6), 1373-1387. e19, 2018 | 816 | 2018 |
Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters E Sharon, Y Kalma, A Sharp, T Raveh-Sadka, M Levo, D Zeevi, L Keren, ... Nature biotechnology 30 (6), 521-530, 2012 | 550 | 2012 |
Self-targeting by CRISPR: gene regulation or autoimmunity? A Stern, L Keren, O Wurtzel, G Amitai, R Sorek Trends in genetics 26 (8), 335-340, 2010 | 473 | 2010 |
Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning NF Greenwald, G Miller, E Moen, A Kong, A Kagel, T Dougherty, ... Nature biotechnology 40 (4), 555-565, 2022 | 453 | 2022 |
MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure L Keren, M Bosse, S Thompson, T Risom, K Vijayaragavan, E McCaffrey, ... Science advances 5 (10), eaax5851, 2019 | 281 | 2019 |
Manipulating nucleosome disfavoring sequences allows fine-tune regulation of gene expression in yeast T Raveh-Sadka, M Levo, U Shabi, B Shany, L Keren, M Lotan-Pompan, ... Nature genetics 44 (7), 743-750, 2012 | 252 | 2012 |
Promoters maintain their relative activity levels under different growth conditions L Keren, O Zackay, M Lotan‐Pompan, U Barenholz, E Dekel, V Sasson, ... Molecular systems biology 9 (1), 701, 2013 | 215 | 2013 |
Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma T Risom, DR Glass, I Averbukh, CC Liu, A Baranski, A Kagel, ... Cell 185 (2), 299-310. e18, 2022 | 205 | 2022 |
Massively parallel interrogation of the effects of gene expression levels on fitness L Keren, J Hausser, M Lotan-Pompan, IV Slutskin, H Alisar, S Kaminski, ... Cell 166 (5), 1282-1294. e18, 2016 | 190 | 2016 |
Central dogma rates and the trade-off between precision and economy in gene expression J Hausser, A Mayo, L Keren, U Alon Nature communications 10 (1), 68, 2019 | 173 | 2019 |
The immunoregulatory landscape of human tuberculosis granulomas EF McCaffrey, M Donato, L Keren, Z Chen, A Delmastro, MB Fitzpatrick, ... Nature immunology 23 (2), 318-329, 2022 | 135 | 2022 |
Probing the effect of promoters on noise in gene expression using thousands of designed sequences E Sharon, D van Dijk, Y Kalma, L Keren, O Manor, Z Yakhini, E Segal Genome research 24 (10), 1698-1706, 2014 | 128 | 2014 |
Sequence features of yeast and human core promoters that are predictive of maximal promoter activity S Lubliner, L Keren, E Segal Nucleic acids research 41 (11), 5569-5581, 2013 | 111 | 2013 |
Noise in gene expression is coupled to growth rate L Keren, D Van Dijk, S Weingarten-Gabbay, D Davidi, G Jona, ... Genome research 25 (12), 1893-1902, 2015 | 92 | 2015 |
Tumor heterogeneity D Pe’er, S Ogawa, O Elhanani, L Keren, TG Oliver, D Wedge Cancer cell 39 (8), 1015-1017, 2021 | 73 | 2021 |
Spatial profiling technologies illuminate the tumor microenvironment O Elhanani, R Ben-Uri, L Keren Cancer Cell 41 (3), 404-420, 2023 | 66 | 2023 |
Compensation for differences in gene copy number among yeast ribosomal proteins is encoded within their promoters D Zeevi, E Sharon, M Lotan-Pompan, Y Lubling, Z Shipony, ... Genome research 21 (12), 2114-2128, 2011 | 63 | 2011 |
Modeling Multiplexed Images with Spatial-LDA Reveals Novel Tissue Microenvironments Z Chen, I Soifer, H Hilton, L Keren, V Jojic Journal of Computational Biology 27 (8), 1204-1218, 2020 | 50 | 2020 |
Adjacent cell marker lateral spillover compensation and reinforcement for multiplexed images Y Bai, B Zhu, X Rovira-Clave, H Chen, M Markovic, CN Chan, TH Su, ... Frontiers in immunology 12, 652631, 2021 | 36 | 2021 |
Multiplexed imaging analysis of the tumor-immune microenvironment reveals predictors of outcome in triple-negative breast cancer A Patwa, R Yamashita, J Long, T Risom, M Angelo, L Keren, DL Rubin Communications Biology 4 (1), 852, 2021 | 33 | 2021 |