G-quadruplex, friend or foe: the role of the G-quartet in anticancer strategies J Carvalho, JL Mergny, GF Salgado, JA Queiroz, C Cruz Trends in Molecular Medicine 26 (9), 848-861, 2020 | 218 | 2020 |
Aptamer-based targeted delivery of a G-quadruplex ligand in cervical cancer cells J Carvalho, A Paiva, MP Cabral Campello, A Paulo, JL Mergny, ... Scientific reports 9 (1), 7945, 2019 | 97 | 2019 |
Circular dichroism of G-Quadruplex: A laboratory experiment for the study of topology and ligand binding J Carvalho, JA Queiroz, C Cruz Journal of Chemical Education 94 (10), 1547-1551, 2017 | 86 | 2017 |
Fluorescent light-up acridine orange derivatives bind and stabilize KRAS-22RT G-quadruplex J Carvalho, E Pereira, J Marquevielle, MPC Campello, JL Mergny, ... Biochimie 144, 144-152, 2018 | 48 | 2018 |
Multicharged phthalocyanines as selective ligands for G-quadruplex DNA structures CIV Ramos, SP Almeida, LMO Lourenço, PMR Pereira, R Fernandes, ... Molecules 24 (4), 733, 2019 | 45 | 2019 |
Aptamer-guided acridine derivatives for cervical cancer J Carvalho, J Lopes-Nunes, AC Lopes, MPC Campello, A Paulo, ... Organic & Biomolecular Chemistry 17 (11), 2992-3002, 2019 | 40 | 2019 |
AS1411 derivatives as carriers of G-quadruplex ligands for cervical cancer cells J Figueiredo, J Lopes-Nunes, J Carvalho, F Antunes, M Ribeiro, ... International Journal of Pharmaceutics 568, 118511, 2019 | 37 | 2019 |
Phthalocyanines for G-quadruplex aptamers binding J Lopes-Nunes, J Carvalho, J Figueiredo, CIV Ramos, LMO Lourenco, ... Bioorganic chemistry 100, 103920, 2020 | 35 | 2020 |
Study of the interaction between indole-based compounds and biologically relevant G-quadruplexes J Carvalho, P Nottelet, JL Mergny, JA Queiroz, GF Salgado, C Cruz Biochimie 135, 186-195, 2017 | 32 | 2017 |
Phenanthroline polyazamacrocycles as G-quadruplex DNA binders J Carvalho, T Quintela, NM Gueddouda, A Bourdoncle, JL Mergny, ... Organic & Biomolecular Chemistry 16 (15), 2776-2786, 2018 | 30 | 2018 |
Metal-based G-quadruplex binders for cancer theranostics E Palma, J Carvalho, C Cruz, A Paulo Pharmaceuticals 14 (7), 605, 2021 | 28 | 2021 |
Development of a bioreactor system for cytotoxic evaluation of pharmacological compounds in living cells using NMR spectroscopy J Carvalho, S Alves, MMCA Castro, CFGC Geraldes, JA Queiroz, ... Journal of pharmacological and toxicological methods 95, 70-78, 2019 | 24 | 2019 |
Targeting Nucleolin By RNA G-Quadruplex-Forming Motif J Figueiredo, A Miranda, J Lopes-Nunes, J Carvalho, D Alexandre, ... Biochemical Pharmacology, 114418, 2021 | 20 | 2021 |
Aptamer-based approaches to detect nucleolin in prostate cancer A Miranda, T Santos, J Carvalho, D Alexandre, A Jardim, CRF Caneira, ... Talanta 226, 122037, 2021 | 19 | 2021 |
Human papillomavirus G-rich regions as potential antiviral drug targets J Carvalho, J Lopes-Nunes, M Campello, A Paulo, J Milici, C Meyers, ... Nucleic Acid Therapeutics 31 (1), 68-81, 2020 | 18 | 2020 |
Ligand screening to pre-miRNA 149 G-quadruplex investigated by molecular dynamics J Carvalho, T Santos, R Carrilho, F Sousa, GF Salgado, JA Queiroz, ... Journal of Biomolecular Structure and Dynamics 38 (8), 2276-2286, 2020 | 15 | 2020 |
Nanoaggregate-forming lipid-conjugated AS1411 aptamer as a promising tumor-targeted delivery system of anticancer agents in vitro J Carvalho, J Lopes-Nunes, B Vialet, T Rosado, E Gallardo, J Vale, ... Nanomedicine: Nanotechnology, Biology and Medicine, 102429, 2021 | 13 | 2021 |
Stabilization of novel immunoglobulin switch regions G-quadruplexes by naphthalene and quinoline-based ligands J Carvalho, J Ferreira, P Pereira, E Coutinho, A Guedin, P Nottelet, ... Tetrahedron 72 (9), 1229-1237, 2016 | 12 | 2016 |
Radiolabeled gold nanoseeds decorated with substance P peptides: synthesis, characterization and in vitro evaluation in glioblastoma cellular models F Silva, A D’Onofrio, C Mendes, C Pinto, A Marques, MPC Campello, ... International Journal of Molecular Sciences 23 (2), 617, 2022 | 11 | 2022 |
Synthesis and biological evaluation of new functionalized nitroindazolylacetonitrile derivatives M Eddahmi, NMM Moura, L Bouissane, MAF Faustino, JAS Cavaleiro, ... ChemistrySelect 4 (48), 14335-14342, 2019 | 10 | 2019 |