| EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers DE Ehrnhoefer, J Bieschke, A Boeddrich, M Herbst, L Masino, R Lurz, ... Nature structural & molecular biology 15 (6), 558-566, 2008 | 1583 | 2008 |
| EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity J Bieschke, J Russ, RP Friedrich, DE Ehrnhoefer, H Wobst, ... Proceedings of the National Academy of Sciences 107 (17), 7710-7715, 2010 | 1091 | 2010 |
| Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin S Okamoto, MA Pouladi, M Talantova, D Yao, P Xia, DE Ehrnhoefer, ... Nature medicine 15 (12), 1407-1413, 2009 | 490 | 2009 |
| Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models DE Ehrnhoefer, M Duennwald, P Markovic, JL Wacker, S Engemann, ... Human molecular genetics 15 (18), 2743-2751, 2006 | 474 | 2006 |
| Autophagy in Huntington disease and huntingtin in autophagy DDO Martin, S Ladha, DE Ehrnhoefer, MR Hayden Trends in neurosciences 38 (1), 26-35, 2015 | 366 | 2015 |
| Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease DE Ehrnhoefer, L Sutton, MR Hayden The Neuroscientist 17 (5), 475-492, 2011 | 209 | 2011 |
| Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin MA Pouladi, RK Graham, JM Karasinska, Y Xie, RD Santos, Å Petersén, ... Brain 132 (4), 919-932, 2009 | 181 | 2009 |
| Caspase-6 and neurodegeneration RK Graham, DE Ehrnhoefer, MR Hayden Trends in neurosciences 34 (12), 646-656, 2011 | 147 | 2011 |
| Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression MA Pouladi, Y Xie, NH Skotte, DE Ehrnhoefer, RK Graham, JE Kim, ... Human molecular genetics 19 (8), 1528-1538, 2010 | 140 | 2010 |
| Mouse models of Huntington disease: variations on a theme DE Ehrnhoefer, SL Butland, MA Pouladi, MR Hayden Disease models & mechanisms 2 (3-4), 123-129, 2009 | 131 | 2009 |
| HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response B Rotblat, AL Southwell, DE Ehrnhoefer, NH Skotte, M Metzler, ... Proceedings of the National Academy of Sciences 111 (8), 3032-3037, 2014 | 107 | 2014 |
| Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development DE Ehrnhoefer, BKY Wong, MR Hayden Nature reviews Drug discovery 10 (11), 853-867, 2011 | 87 | 2011 |
| Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice V Uribe, BKY Wong, RK Graham, CL Cusack, NH Skotte, MA Pouladi, ... Human molecular genetics 21 (9), 1954-1967, 2012 | 79 | 2012 |
| A validated antibody panel for the characterization of tau post-translational modifications E Ercan, S Eid, C Weber, A Kowalski, M Bichmann, A Behrendt, F Matthes, ... Molecular neurodegeneration 12, 1-19, 2017 | 77 | 2017 |
| A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits I Aharony, DE Ehrnhoefer, A Shruster, X Qiu, S Franciosi, MR Hayden, ... Human molecular genetics 24 (9), 2604-2614, 2015 | 70 | 2015 |
| A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain E Ercan-Herbst, J Ehrig, DC Schöndorf, A Behrendt, B Klaus, ... Acta neuropathologica communications 7, 1-19, 2019 | 64 | 2019 |
| Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice BKY Wong, DE Ehrnhoefer, RK Graham, DDO Martin, S Ladha, V Uribe, ... Neurobiology of disease 76, 24-36, 2015 | 63 | 2015 |
| Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease DE Ehrnhoefer, DDO Martin, ME Schmidt, X Qiu, S Ladha, NS Caron, ... Acta neuropathologica communications 6, 1-16, 2018 | 59 | 2018 |
| p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin DE Ehrnhoefer, NH Skotte, S Ladha, YTN Nguyen, X Qiu, Y Deng, ... Human molecular genetics 23 (3), 717-729, 2014 | 59 | 2014 |
| NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease MA Pouladi, E Brillaud, Y Xie, P Conforti, RK Graham, DE Ehrnhoefer, ... Neurobiology of disease 48 (3), 282-289, 2012 | 53 | 2012 |
Niels Henning SkotteAssistant Professor, Department for Drug Design and Pharmacology, UCPH在 sund.ku.dk 的电子邮件经过验证
