Cartilage regeneration and ageing: targeting cellular plasticity in osteoarthritis M Varela-Eirin, J Loureiro, E Fonseca, S Corrochano, JR Caeiro, ... Ageing research reviews 42, 56-71, 2018 | 191 | 2018 |
A senescence-centric view of aging: implications for longevity and disease M Borghesan, WMH Hoogaars, M Varela-Eirin, N Talma, M Demaria Trends in Cell Biology 30 (10), 777-791, 2020 | 178 | 2020 |
Algorithmic assessment of cellular senescence in experimental and clinical specimens J Kohli, B Wang, SM Brandenburg, N Basisty, K Evangelou, ... Nature protocols 16 (5), 2471-2498, 2021 | 115 | 2021 |
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression T van Vliet, M Varela-Eirin, B Wang, M Borghesan, SM Brandenburg, ... Molecular Cell 81 (9), 2041-2052. e6, 2021 | 85 | 2021 |
Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis M Varela-Eirín, A Varela-Vázquez, A Guitián-Caamaño, CL Paíno, V Mato, ... Cell death & disease 9 (12), 1166, 2018 | 83 | 2018 |
Recruitment of RNA molecules by connexin RNA-binding motifs: Implication in RNA and DNA transport through microvesicles and exosomes M Varela-Eirin, A Varela-Vazquez, MRC Mateos, A Vila-Sanjurjo, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (4), 728-736, 2017 | 60 | 2017 |
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity B Wang, M Varela‐Eirin, SM Brandenburg, A Hernandez‐Segura, ... The EMBO journal 41 (6), e108946, 2022 | 52 | 2022 |
Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis M Varela-Eirín, P Carpintero-Fernández, A Sánchez-Temprano, ... Aging (Albany NY) 12 (16), 15882, 2020 | 40 | 2020 |
Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression M Varela-Eirín, P Carpintero-Fernández, A Guitián-Caamaño, ... Cell death & disease 13 (8), 681, 2022 | 28 | 2022 |
The C-terminal domain of connexin43 modulates cartilage structure via chondrocyte phenotypic changes R Gago-Fuentes, JF Bechberger, M Varela-Eirin, A Varela-Vazquez, ... Oncotarget 7 (45), 73055, 2016 | 24 | 2016 |
New therapeutic strategies for osteoarthritis by targeting sialic acid receptors P Carpintero-Fernandez, M Varela-Eirin, A Lacetera, R Gago-Fuentes, ... biomolecules 10 (4), 637, 2020 | 22 | 2020 |
Cellular senescence M Varela-Eirín, M Demaria Current Biology 32 (10), R448-R452, 2022 | 16 | 2022 |
High dietary protein and fat contents exacerbate hepatic senescence and SASP in mice J Nehme, D Yang, A Altulea, M Varela‐Eirin, L Wang, S Hu, Y Wu, J Togo, ... The FEBS Journal 290 (5), 1340-1347, 2023 | 12 | 2023 |
Osteoarthritis: mechanistic insights, senescence, and novel therapeutic opportunities P Carpintero-Fernández, M Varela-Eirín, A García-Yuste, I López-Díaz, ... Bioelectricity 4 (1), 39-47, 2022 | 1 | 2022 |
Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury J Nehme, L Mesilmany, M Varela-Eirin, S Brandenburg, A Altulea, Y Lin, ... Nature Aging, 1-12, 2024 | | 2024 |
Molecular mechanisms of cellular senescence J Nehme, M Varela-Eirin, M Demaria Regenerative Nephrology, 221-230, 2022 | | 2022 |