| RPN-6 determines C. elegans longevity under proteotoxic stress conditions D Vilchez, I Morantte, Z Liu, PM Douglas, C Merkwirth, APC Rodrigues, ... Nature 489 (7415), 263-268, 2012 | 443 | 2012 |
| Protein homeostasis and aging in neurodegeneration PM Douglas, A Dillin Journal of Cell Biology 190 (5), 719-729, 2010 | 416 | 2010 |
| Chaperone-dependent amyloid assembly protects cells from prion toxicity PM Douglas, S Treusch, HY Ren, R Halfmann, ML Duennwald, ... Proceedings of the National Academy of Sciences 105 (20), 7206-7211, 2008 | 198 | 2008 |
| HSF-1–mediated cytoskeletal integrity determines thermotolerance and life span NA Baird, PM Douglas, MS Simic, AR Grant, JJ Moresco, SC Wolff, ... Science 346 (6207), 360-363, 2014 | 180 | 2014 |
| Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan C Wang, H Niederstrasser, PM Douglas, R Lin, J Jaramillo, Y Li, ... Nature communications 8 (1), 2270, 2017 | 145 | 2017 |
| Heterotypic signals from neural HSF-1 separate thermotolerance from longevity PM Douglas, NA Baird, MS Simic, S Uhlein, MA McCormick, SC Wolff, ... Cell reports 12 (7), 1196-1204, 2015 | 104 | 2015 |
| Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones DW Summers, PM Douglas, CHI Ramos, DM Cyr Trends in biochemical sciences 34 (5), 230-233, 2009 | 102 | 2009 |
| Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways PM Douglas, DW Summers, DM Cyr Prion 3 (2), 51-58, 2009 | 61 | 2009 |
| The type I Hsp40 Ydj1 utilizes a farnesyl moiety and zinc finger-like region to suppress prion toxicity DW Summers, PM Douglas, HY Ren, DM Cyr Journal of Biological Chemistry 284 (6), 3628-3639, 2009 | 46 | 2009 |
| The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1 … R Das, JA Melo, M Thondamal, EA Morton, AB Cornwell, B Crick, JH Kim, ... PLoS genetics 13 (10), e1007038, 2017 | 40 | 2017 |
| Reciprocal efficiency of RNQ1 and polyglutamine detoxification in the cytosol and nucleus PM Douglas, DW Summers, HY Ren, DM Cyr Molecular biology of the cell 20 (19), 4162-4173, 2009 | 37 | 2009 |
| Prion propagation by Hsp40 molecular chaperones DW Summers, PM Douglas, DM Cyr Prion 3 (2), 59-64, 2009 | 36 | 2009 |
| Interplay between protein homeostasis networks in protein aggregation and proteotoxicity PM Douglas, DM Cyr Biopolymers: Original Research on Biomolecules 93 (3), 229-236, 2010 | 34 | 2010 |
| Age-onset phosphorylation of a minor actin variant promotes intestinal barrier dysfunction N Egge, SLB Arneaud, P Wales, M Mihelakis, J McClendon, RS Fonseca, ... Developmental cell 51 (5), 587-601. e7, 2019 | 33 | 2019 |
| The disposable soma theory of aging in reverse PM Douglas, A Dillin Cell Research 24 (1), 7-8, 2014 | 22 | 2014 |
| Quantitative pupillometry in patients with traumatic brain injury and loss of consciousness: A prospective pilot study JI Traylor, TY El Ahmadieh, NM Bedros, N Al Adli, SE Stutzman, ... Journal of clinical neuroscience 91, 88-92, 2021 | 18 | 2021 |
| Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration R Solano Fonseca, P Metang, N Egge, Y Liu, KR Zuurbier, ... Elife 10, e69438, 2021 | 16* | 2021 |
| Intracellular lipid surveillance by small G protein geranylgeranylation A Watterson, L Tatge, N Wajahat, SLB Arneaud, R Solano Fonseca, ... Nature 605 (7911), 736-740, 2022 | 14 | 2022 |
| The stress response paradox: fighting degeneration at the cost of cancer SLB Arneaud, PM Douglas The FEBS journal 283 (22), 4047-4055, 2016 | 13 | 2016 |
| Loss of heat shock factor initiates intracellular lipid surveillance by actin destabilization A Watterson, SLB Arneaud, N Wajahat, JM Wall, L Tatge, ST Beheshti, ... Cell reports 41 (3), 2022 | 11 | 2022 |
