| JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin BA Witthuhn, FW Quelle, O Silvennoinen, T Yi, B Tang, O Miura, JN Ihle Cell 74 (2), 227-236, 1993 | 1461 | 1993 |
| Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components N Stahl, TG Boulton, T Farruggella, NY Ip, S Davis, BA Witthuhn, ... Science 263 (5143), 92-95, 1994 | 1264 | 1994 |
| Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase LS Argetsinger, GS Campbell, X Yang, BA Witthuhn, O Silvennoinen, ... Cell 74 (2), 237-244, 1993 | 1248 | 1993 |
| The protein tyrosine kinase JAK1 complements defects in interferon-α/β and-γ signal transduction M Müller, J Briscoe, C Laxton, D Guschin, A Ziemiecki, O Silvennoinen, ... Nature 366 (6451), 129-135, 1993 | 942 | 1993 |
| Signaling by the cytokine receptor superfamily: JAKs and STATs JN Ihle, BA Witthuhn, FW Quelle, K Yamamoto, WE Thierfelder, B Kreider, ... Trends in biochemical sciences 19 (5), 222-227, 1994 | 857 | 1994 |
| Interaction of IL-2Rβ and γc Chains with Jak1 and Jak3: Implications for XSCID and XCID SM Russell, JA Johnston, M Noguchi, M Kawamura, CM Bacon, ... Science 266 (5187), 1042-1045, 1994 | 837 | 1994 |
| Signaling through the hematopoietic cytokine receptors JN Ihle, BA Witthuhn, FW Quelle, K Yamamoto, O Silvennoinen Annual review of immunology 13 (1), 369-398, 1995 | 827 | 1995 |
| Defective lymphoid development in mice lacking Jak3 T Nosaka, JMA Van Deursen, RA Tripp, WE Thierfelder, BA Witthuhn, ... Science 270 (5237), 800-802, 1995 | 790 | 1995 |
| Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells BA Witthuhn, O Silvennoinen, O Miura, KS Lai, C Cwik, ET Liu, JN Ihle Nature 370 (6485), 153-157, 1994 | 767 | 1994 |
| Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits T Miyazaki, A Kawahara, H Fujii, Y Nakagawa, Y Minami, ZJ Liu, I Oishi, ... Science 266 (5187), 1045-1047, 1994 | 724 | 1994 |
| Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. O Silvennoinen, BA Witthuhn, FW Quelle, JL Cleveland, T Yi, JN Ihle Proceedings of the National Academy of Sciences 90 (18), 8429-8433, 1993 | 632 | 1993 |
| A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin‐6. D Guschin, N Rogers, J Briscoe, B Witthuhn, D Watling, F Horn, ... The EMBO journal 14 (7), 1421-1429, 1995 | 621 | 1995 |
| Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway D Watling, D Guschin, M Müller, O Silvennoinen, BA Witthuhn, FW Quelle, ... Nature 366 (6451), 166-170, 1993 | 620 | 1993 |
| JAK2 associates with the βc chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region FW Quelle, N Sato, BA Witthuhn, RC Inhorn, M Eder, A Miyajima, ... Molecular and cellular biology, 1994 | 593 | 1994 |
| Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop J Feng, BA Witthuhn, T Matsuda, F Kohlhuber, IM Kerr, JN Ihle Molecular and cellular biology, 1997 | 468 | 1997 |
| Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. M Narazaki, BA Witthuhn, K Yoshida, O Silvennoinen, K Yasukawa, ... Proceedings of the National Academy of Sciences 91 (6), 2285-2289, 1994 | 382 | 1994 |
| Kinase‐negative mutants of JAK1 can sustain interferon‐gamma‐inducible gene expression but not an antiviral state. J Briscoe, NC Rogers, BA Witthuhn, D Watling, AG Harpur, AF Wilks, ... The EMBO journal 15 (4), 799-809, 1996 | 273 | 1996 |
| A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses FK Kohlhuber, NC Rogers, D Watling, J Feng, D Guschin, J Briscoe, ... Molecular and cellular biology 17 (2), 695-706, 1997 | 267 | 1997 |
| Activation of JAK kinases and STAT proteins by interleukin‐2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. C Beadling, D Guschin, BA Witthuhn, A Ziemiecki, JN Ihle, IM Kerr, ... The EMBO journal 13 (23), 5605-5615, 1994 | 262 | 1994 |
| Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo O Miura, N Nakamura, FW Quelle, BA Witthuhn, JN Ihle, N Aoki Blood 84 (5), 1501-1507, 1994 | 212 | 1994 |
