| A TOG: αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase P Ayaz, X Ye, P Huddleston, CA Brautigam, LM Rice Science 337 (6096), 857-860, 2012 | 270 | 2012 |
| A tethered delivery mechanism explains the catalytic action of a microtubule polymerase P Ayaz, S Munyoki, EA Geyer, FA Piedra, ES Vu, R Bromberg, ... Elife 3, e03069, 2014 | 136 | 2014 |
| Structural basis of AZD9291 selectivity for EGFR T790M XE Yan, P Ayaz, SJ Zhu, P Zhao, L Liang, CH Zhang, YC Wu, JL Li, ... Journal of medicinal chemistry 63 (15), 8502-8511, 2020 | 88 | 2020 |
| Design, overexpression, and purification of polymerization-blocked yeast αβ-tubulin mutants V Johnson, P Ayaz, P Huddleston, LM Rice Biochemistry 50 (40), 8636-8644, 2011 | 87 | 2011 |
| Conformational adaption may explain the slow dissociation kinetics of roniciclib (BAY 1000394), a type I CDK inhibitor with kinetic selectivity for CDK2 and CDK9 P Ayaz, D Andres, DA Kwiatkowski, CC Kolbe, P Lienau, G Siemeister, ... ACS chemical biology 11 (6), 1710-1719, 2016 | 73 | 2016 |
| A universal homogeneous assay for high-throughput determination of binding kinetics F Schiele, P Ayaz, A Fernández-Montalván Analytical biochemistry 468, 42-49, 2015 | 70 | 2015 |
| Structural mechanism of a drug-binding process involving a large conformational change of the protein target P Ayaz, A Lyczek, YT Paung, VR Mingione, RE Iacob, PW de Waal, ... Nature communications 14 (1), 1885, 2023 | 61 | 2023 |
| RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations V Subbiah, V Sahai, D Maglic, K Bruderek, BB Touré, S Zhao, R Valverde, ... Cancer discovery 13 (9), 2012-2031, 2023 | 57 | 2023 |
| Classification of drug molecules considering their IC50 values using mixed-integer linear programming based hyper-boxes method P Armutlu, ME Ozdemir, F Uney-Yuksektepe, IH Kavakli, M Turkay Bmc Bioinformatics 9, 1-14, 2008 | 35 | 2008 |
| Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization C Agnew, P Ayaz, R Kashima, HS Loving, P Ghatpande, JE Kung, ... Nature communications 12 (1), 4950, 2021 | 27 | 2021 |
| RLY-4008, a novel precision therapy for FGFR2-driven cancers designed to potently and selectively inhibit FGFR2 and FGFR2 resistance mutations J Casaletto, D Maglic, BB Toure, A Taylor, H Schoenherr, B Hudson, ... Cancer Research 81 (13_Supplement), 1455-1455, 2021 | 20 | 2021 |
| Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2 H Schönherr, P Ayaz, AM Taylor, JB Casaletto, BB Touré, DT Moustakas, ... Proceedings of the National Academy of Sciences 121 (6), e2317756121, 2024 | 16 | 2024 |
| Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers MR Campbell, A Ruiz-Saenz, E Peterson, C Agnew, P Ayaz, S Garfinkle, ... Cell reports 38 (5), 2022 | 16 | 2022 |
| Discovery of novel CYP17 inhibitors for the treatment of prostate cancer with structure-based drug design P Armutlu, ME Ozdemir, S Ozdas, İH Kavakli, M Turkay Letters in Drug Design & Discovery 6 (5), 337-344, 2009 | 14 | 2009 |
| Structural models of full-length JAK2 kinase P Ayaz, HM Hammarén, J Raivola, D Sharon, SR Hubbard, ... bioRxiv, 727727, 2019 | 7 | 2019 |
| The Use of Structural Information to Understand Binding Kinetics F Schiele, P Ayaz, A Müller‐Fahrnow Thermodynamics and Kinetics of Drug Binding, 237-256, 2015 | 2 | 2015 |
| Corrigendum to" A universal, homogenous assay for high throughput determination of binding kinetics"[Anal. Biochem. 468 (2015) 42-49]. F Schiele, P Ayaz, A Fernández-Montalván Analytical Biochemistry 514, 1-1, 2016 | 1 | 2016 |
| Suggested searches S Rathje, DM Mirea, I Sucholutsky, R Marjieh, JJ Van Bavel, KA Dill, ... Perspective, 2024 | | 2024 |
| Fgfr inhibitors and methods of use thereof BB TOURÉ, H Schoenherr, AM Taylor, F Giordanetto, DT Moustakas, ... | | 2023 |
| Fgfr inhibitors and methods of use thereof B Touré, H Schoenherr, AM Taylor, F Giordanetto, DT Moustakas, ... US Patent App. 17/595,257, 2023 | | 2023 |
