| Two flavoenzymes catalyze the post-translational generation of 5-chlorotryptophan and 2-aminovinyl-cysteine during NAI-107 biosynthesis MA Ortega, DP Cogan, S Mukherjee, N Garg, B Li, GN Thibodeaux, ... ACS chemical biology 12 (2), 548-557, 2017 | 90 | 2017 |
| Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis DP Cogan, GA Hudson, Z Zhang, TV Pogorelov, WA Van Der Donk, ... Proceedings of the National Academy of Sciences 114 (49), 12928-12933, 2017 | 77 | 2017 |
| Mapping the catalytic conformations of an assembly-line polyketide synthase module DP Cogan, K Zhang, X Li, S Li, GD Pintilie, SH Roh, CS Craik, W Chiu, ... Science 374 (6568), 729-734, 2021 | 58 | 2021 |
| Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics IR Bothwell, DP Cogan, T Kim, CJ Reinhardt, WA van der Donk, SK Nair Proceedings of the National Academy of Sciences 116 (35), 17245-17250, 2019 | 48 | 2019 |
| Inhibition of the human proteasome by imidazoline scaffolds LM Azevedo, TA Lansdell, JR Ludwig, RA Mosey, DK Woloch, DP Cogan, ... Journal of medicinal chemistry 56 (14), 5974-5978, 2013 | 47 | 2013 |
| Molecular basis for resistance against phosphonate antibiotics and herbicides JR Chekan, DP Cogan, SK Nair MedChemComm 7 (1), 28-36, 2016 | 39 | 2016 |
| Substrate-assisted enzymatic formation of lysinoalanine in duramycin L An, DP Cogan, CD Navo, G Jiménez-Osés, SK Nair, WA van der Donk Nature chemical biology 14 (10), 928-933, 2018 | 33 | 2018 |
| Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, in Rhodopseudomonas palustris DP Cogan, C Baraquet, CS Harwood, SK Nair Journal of Biological Chemistry 293 (30), 11727-11735, 2018 | 20 | 2018 |
| In vivo visualization and molecular targeting of the cardiac conduction system WR Goodyer, BM Beyersdorf, L Duan, NS van den Berg, S Mantri, ... The Journal of Clinical Investigation 132 (20), 2022 | 19 | 2022 |
| Antibody probes of module 1 of the 6-deoxyerythronolide B synthase reveal an extended conformation during ketoreduction DP Cogan, X Li, N Sevillano, II Mathews, T Matsui, CS Craik, C Khosla Journal of the American Chemical Society 142 (35), 14933-14939, 2020 | 13 | 2020 |
| Structural basis for enzymatic off-loading of Hybrid Polyketides by Dieckmann Condensation DP Cogan, J Ly, SK Nair ACS chemical biology 15 (10), 2783-2791, 2020 | 10 | 2020 |
| Structure and Mechanisms of Assembly-Line Polyketide Synthases AM Soohoo, DP Cogan, KL Brodsky, C Khosla Annual Review of Biochemistry 93, 2024 | 9 | 2024 |
| Structure and mechanism for iterative amide N-methylation in the biosynthesis of channel-forming peptide cytotoxins DP Cogan, A Bhushan, R Reyes, L Zhu, J Piel, SK Nair Proceedings of the National Academy of Sciences 119 (13), e2116578119, 2022 | 6 | 2022 |
| Discovery and characterization of antibody probes of module 2 of the 6-deoxyerythronolide B synthase KM Guzman, DP Cogan, KL Brodsky, AM Soohoo, X Li, N Sevillano, ... Biochemistry 62 (11), 1589-1593, 2023 | 4 | 2023 |
| Structural basis for intermodular communication in assembly-line polyketide biosynthesis DP Cogan, AM Soohoo, M Chen, Y Liu, KL Brodsky, C Khosla Nature Chemical Biology, 1-7, 2024 | | 2024 |
| Understanding and Engineering Chain Translocation in Assembly-Line Polyketide Synthases A Soohoo, D Cogan, C Khosla 2023 AIChE Annual Meeting, 2023 | | 2023 |
| Structural Biology of RiPP Natural Products Biosynthesis SH Dong, DP Cogan, SK Nair Comprehensive Natural Products III, 17-48, 2020 | | 2020 |
| Supporting Information Two flavoenzymes catalyze the post-translational generation of 5-chlorotryptophan and 2-aminovinyl-cysteine during NAI-107 biosynthesis MA Ortega, DP Cogan, S Mukherjee, N Garg, B Li, GN Thibodeaux, ... | | |
