| From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis B Springthorpe, A Bailey, P Barton, TN Birkinshaw, RV Bonnert, ... Bioorganic & medicinal chemistry letters 17 (21), 6013-6018, 2007 | 295 | 2007 |
| Mass spectrometry imaging in drug development A Nilsson, RJA Goodwin, M Shariatgorji, T Vallianatou, PJH Webborn, ... Analytical chemistry 87 (3), 1437-1455, 2015 | 192 | 2015 |
| Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo MG Soars, K Grime, JL Sproston, PJH Webborn, RJ Riley Drug metabolism and disposition 35 (6), 859-865, 2007 | 168 | 2007 |
| Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists A Baxter, J Bent, K Bowers, M Braddock, S Brough, M Fagura, M Lawson, ... Bioorganic & medicinal chemistry letters 13 (22), 4047-4050, 2003 | 147 | 2003 |
| Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes SW Paine, AJ Parker, P Gardiner, PJH Webborn, RJ Riley Drug Metabolism and Disposition 36 (7), 1365-1374, 2008 | 124 | 2008 |
| Mass spectrometry imaging of cassette-dosed drugs for higher throughput pharmacokinetic and biodistribution analysis JG Swales, JW Tucker, N Strittmatter, A Nilsson, D Cobice, MR Clench, ... Analytical chemistry 86 (16), 8473-8480, 2014 | 107 | 2014 |
| Drug-phospholipid interactions. 2. Predicting the sites of drug distribution using n-octanol/water and membrane/water distribution coefficients P Barton, AM Davis, PJH Webborn, DJ McCarthy Journal of pharmaceutical sciences 86 (9), 1034-1039, 1997 | 85 | 1997 |
| In vitro–in vivo extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects PJH Webborn, AJ Parker, RL Denton, RJ Riley Xenobiotica 37 (10-11), 1090-1109, 2007 | 79 | 2007 |
| Spatial quantitation of drugs in tissues using liquid extraction surface analysis mass spectrometry imaging JG Swales, N Strittmatter, JW Tucker, MR Clench, PJH Webborn, ... Scientific reports 6 (1), 37648, 2016 | 73 | 2016 |
| Mapping drug distribution in brain tissue using liquid extraction surface analysis mass spectrometry imaging JG Swales, JW Tucker, MJ Spreadborough, SL Iverson, MR Clench, ... Analytical chemistry 87 (19), 10146-10152, 2015 | 70 | 2015 |
| Impact of hepatic uptake transporters on pharmacokinetics and drug− drug interactions: use of assays and models for decision making in the pharmaceutical industry MG Soars, PJH Webborn, RJ Riley Molecular pharmaceutics 6 (6), 1662-1677, 2009 | 69 | 2009 |
| AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis WD Hong, F Benayoud, GL Nixon, L Ford, KL Johnston, RH Clare, ... Proceedings of the National Academy of Sciences 116 (4), 1414-1419, 2019 | 67 | 2019 |
| Discovery of potent and selective adamantane-based small-molecule P2X7 receptor antagonists/interleukin-1β inhibitors M Furber, L Alcaraz, JE Bent, A Beyerbach, K Bowers, M Braddock, ... Journal of medicinal chemistry 50 (24), 5882-5885, 2007 | 66 | 2007 |
| The right compound in the right assay at the right time: an integrated discovery DMPK strategy P Ballard, P Brassil, KH Bui, H Dolgos, C Petersson, A Tunek, ... Drug metabolism reviews 44 (3), 224-252, 2012 | 63 | 2012 |
| Design of Helicobacter pylori glutamate racemase inhibitors as selective antibacterial agents: a novel pro-drug approach to increase exposure GS Basarab, PJ Hill, A Rastagar, PJH Webborn Bioorganic & medicinal chemistry letters 18 (16), 4716-4722, 2008 | 41 | 2008 |
| Robust assessment of statistical significance in the use of unbound/intrinsic pharmacokinetic parameters in quantitative structure–pharmacokinetic relationships with lipophilicity AM Davis, PJH Webborn, DW Salt Drug metabolism and disposition 28 (2), 103-106, 2000 | 29 | 2000 |
| Functional consequences of active hepatic uptake on cytochrome P450 inhibition in rat and human hepatocytes K Grime, PJH Webborn, RJ Riley Drug metabolism and disposition 36 (8), 1670-1678, 2008 | 28 | 2008 |
| Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead exploration V Oza, S Ashwell, P Brassil, J Breed, C Deng, J Ezhuthachan, H Haye, ... Bioorganic & medicinal chemistry letters 20 (17), 5133-5138, 2010 | 26 | 2010 |
| Hepatic uptake in the dog: comparison of uptake in hepatocytes and human embryonic kidney cells expressing dog organic anion-transporting polypeptide 1B4 AJ Wilby, K Maeda, PF Courtney, Y Debori, PJH Webborn, Y Kitamura, ... Drug metabolism and disposition 39 (12), 2361-2369, 2011 | 23 | 2011 |
| Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092 A Bahl, P Barton, K Bowers, MV Caffrey, R Denton, P Gilmour, S Hawley, ... Bioorganic & medicinal chemistry letters 22 (21), 6694-6699, 2012 | 22 | 2012 |
