| Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation P Koivunen, S Lee, CG Duncan, G Lopez, G Lu, S Ramkissoon, ... Nature 483 (7390), 484-488, 2012 | 844 | 2012 |
| (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible JA Losman, RE Looper, P Koivunen, S Lee, RK Schneider, C McMahon, ... Science 339 (6127), 1621-1625, 2013 | 783 | 2013 |
| Transaminase inhibition by 2-hydroxyglutarate impairs glutamate biosynthesis and redox homeostasis in glioma SK McBrayer, JR Mayers, GJ DiNatale, DD Shi, J Khanal, AA Chakraborty, ... Cell 175 (1), 101-116. e25, 2018 | 310 | 2018 |
| Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate J Fan, X Teng, L Liu, KR Mattaini, RE Looper, MG Vander Heiden, ... ACS chemical biology 10 (2), 510-516, 2015 | 191 | 2015 |
| Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity MR Kaadige, RE Looper, S Kamalanaadhan, DE Ayer Proceedings of the National Academy of Sciences 106 (35), 14878-14883, 2009 | 188 | 2009 |
| Addition–hydroamination reactions of propargyl cyanamides: rapid access to highly substituted 2‐aminoimidazoles RL Giles, JD Sullivan, AM Steiner, RE Looper Angewandte Chemie International Edition 48 (17), 3116-3120, 2009 | 126 | 2009 |
| Regioselective Rh (II)-catalyzed hydroaminations of propargylguanidines MJ Gainer, NR Bennett, Y Takahashi, RE Looper Angewandte Chemie (International ed. in English) 50 (3), 684, 2011 | 117 | 2011 |
| Mutant IDH1 promotes glioma formation in vivo B Philip, XY Diana, MR Silvis, CH Shin, JP Robinson, GL Robinson, ... Cell reports 23 (5), 1553-1564, 2018 | 104 | 2018 |
| 2-Aminoimidazoles from Leucetta Sponges: Synthesis and biology of an important pharmacophore JD Sullivan, RL Giles, RE Looper Current Bioactive Compounds 5 (1), 39-78, 2009 | 101 | 2009 |
| Blueberry metabolites attenuate lipotoxicity‐induced endothelial dysfunction D Bharat, RRM Cavalcanti, C Petersen, N Begaye, BR Cutler, MMA Costa, ... Molecular nutrition & food research 62 (2), 1700601, 2018 | 85 | 2018 |
| Synthesis of the putative structure of 7‐deoxycylindrospermopsin: C7 oxygenation is not required for the inhibition of protein synthesis RE Looper, MTC Runnegar, RM Williams Angewandte Chemie International Edition 44 (25), 3879-3881, 2005 | 84 | 2005 |
| A stereocontrolled synthesis of (+)-saxitoxin VR Bhonde, RE Looper Journal of the American Chemical Society 133 (50), 20172-20174, 2011 | 80 | 2011 |
| Total synthesis of (±)-heliannuol D, an allelochemical from Helianthus annuus JR Vyvyan, RE Looper Tetrahedron Letters 41 (8), 1151-1154, 2000 | 72 | 2000 |
| De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma DD Shi, MR Savani, MM Levitt, AC Wang, JE Endress, CE Bird, J Buehler, ... Cancer cell 40 (9), 939-956. e16, 2022 | 65 | 2022 |
| Macrocycloadditions leading to conformationally restricted small molecules RE Looper, D Pizzirani, SL Schreiber Organic letters 8 (10), 2063-2066, 2006 | 65 | 2006 |
| Syntheses of the cylindrospermopsin alkaloids RE Looper, MTC Runnegar, RM Williams Tetrahedron 62 (18), 4549-4562, 2006 | 61 | 2006 |
| Synthesis of aromatic bisabolene natural products via palladium-catalyzed cross-couplings of organozinc reagents JR Vyvyan, C Loitz, RE Looper, CS Mattingly, EA Peterson, ST Staben The Journal of Organic Chemistry 69 (7), 2461-2468, 2004 | 60 | 2004 |
| A concise asymmetric synthesis of the marine hepatotoxin 7-epicylindrospermopsin RE Looper, RM Williams Angewandte Chemie International Edition 43 (22), 2930-2933, 2004 | 51 | 2004 |
| Construction of the A-ring of cylindrospermopsin via an intramolecular oxazinone-N-oxide dipolar cycloaddition RE Looper, RM Williams Tetrahedron letters 42 (5), 769-771, 2001 | 45 | 2001 |
| Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases T Laukka, M Myllykoski, RE Looper, P Koivunen Journal of molecular biology 430 (18), 3081-3092, 2018 | 44 | 2018 |
