| Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation SV Ley, IR Baxendale, RN Bream, PS Jackson, AG Leach, ... Journal of the Chemical Society, Perkin Transactions 1, 3815-4195, 2000 | 964 | 2000 |
| An umpolung approach to alkene carboamination: palladium catalyzed 1, 2-amino-acylation,-carboxylation,-arylation,-vinylation, and-alkynylation A Faulkner, JS Scott, JF Bower Journal of the American Chemical Society 137 (22), 7224-7230, 2015 | 191 | 2015 |
| Potent and selective inhibitors of MTH1 probe its role in cancer cell survival JG Kettle, H Alwan, M Bista, J Breed, NL Davies, K Eckersley, S Fillery, ... Journal of medicinal chemistry 59 (6), 2346-2361, 2016 | 154 | 2016 |
| Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents J Habermann, SV Ley, JS Scott Journal of the Chemical Society, Perkin Transactions 1, 1253-1256, 1999 | 145 | 1999 |
| Copper catalyzed Heck-like cyclizations of oxime esters A Faulkner, NJ Race, JS Scott, JF Bower Chemical Science 5 (6), 2416-2421, 2014 | 144 | 2014 |
| Medicinal chemistry of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) JS Scott, FW Goldberg, AV Turnbull Journal of Medicinal Chemistry 57 (11), 4466-4486, 2014 | 103 | 2014 |
| Systematic investigation of lipophilicity modulation by aliphatic fluorination motifs B Jeffries, Z Wang, HR Felstead, JY Le Questel, JS Scott, E Chiarparin, ... Journal of Medicinal Chemistry 63 (3), 1002-1031, 2020 | 101 | 2020 |
| Highly selective entry to the azadirachtin skeleton via a Claisen rearrangement/radical cyclization sequence T Durand-Reville, LB Gobbi, BL Gray, SV Ley, JS Scott Organic Letters 4 (22), 3847-3850, 2002 | 97 | 2002 |
| Reducing the Lipophilicity of Perfluoroalkyl Groups by CF2–F/CF2–Me or CF3/CH3 Exchange B Jeffries, Z Wang, J Graton, SD Holland, T Brind, RDR Greenwood, ... Journal of medicinal chemistry 61 (23), 10602-10618, 2018 | 89 | 2018 |
| Total synthesis of rapamycin SV Ley, MN Tackett, ML Maddess, JC Anderson, PE Brennan, MW Cappi, ... Chemistry–A European Journal 15 (12), 2874-2914, 2009 | 88 | 2009 |
| Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation JS Scott, AM Birch, KJ Brocklehurst, A Broo, HS Brown, RJ Butlin, ... Journal of Medicinal Chemistry 55 (11), 5361-5379, 2012 | 77 | 2012 |
| Total synthesis of rapamycin ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, ... Angewandte Chemie International Edition 46 (4), 591-597, 2007 | 77 | 2007 |
| Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist JS Scott, TA Moss, A Balazs, B Barlaam, J Breed, RJ Carbajo, ... Journal of medicinal chemistry 63 (23), 14530-14559, 2020 | 75 | 2020 |
| Palladium catalyzed cyclizations of oxime esters with 1, 1-disubstituted alkenes: synthesis of α, α-disubstituted dihydropyrroles and studies towards an asymmetric protocol A Faulkner, JS Scott, JF Bower Chemical Communications 49 (15), 1521-1523, 2013 | 73 | 2013 |
| Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents J Habermann, SV Ley, JS Scott Journal of the Chemical Society, Perkin Transactions 1, 3127-3130, 1998 | 70 | 1998 |
| The synthesis of azadirachtin: a potent insect antifeedant SV Ley, A Abad‐Somovilla, JC Anderson, C Ayats, R Bänteli, ... Chemistry–A European Journal 14 (34), 10683-10704, 2008 | 69 | 2008 |
| Lowering lipophilicity by adding carbon: one-carbon bridges of morpholines and piperazines SL Degorce, MS Bodnarchuk, IA Cumming, JS Scott Journal of Medicinal Chemistry 61 (19), 8934-8943, 2018 | 64 | 2018 |
| The brucine N-oxide-promoted asymmetric Pauson–Khand reaction WJ Kerr, DM Lindsay, EM Rankin, JS Scott, SP Watson Tetrahedron Letters 41 (17), 3229-3233, 2000 | 61 | 2000 |
| Development of a practical Buchwald–Hartwig amine arylation protocol using a conveniently prepared (NHC) Pd (R-allyl) Cl catalyst MJ Cawley, FGN Cloke, RJ Fitzmaurice, SE Pearson, JS Scott, S Caddick Organic & Biomolecular Chemistry 6 (15), 2820-2825, 2008 | 60 | 2008 |
| Practical application of ligand efficiency metrics in lead optimisation JS Scott, MJ Waring Bioorganic & Medicinal Chemistry 26 (11), 3006-3015, 2018 | 58 | 2018 |
