Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities FM Menzies, A Fleming, A Caricasole, CF Bento, SP Andrews, ... Neuron 93 (5), 1015-1034, 2017 | 1144 | 2017 |
Small molecules, big targets: drug discovery faces the protein–protein interaction challenge DE Scott, AR Bayly, C Abell, J Skidmore Nature Reviews Drug Discovery 15 (8), 533-550, 2016 | 1109 | 2016 |
The different autophagy degradation pathways and neurodegeneration A Fleming, M Bourdenx, M Fujimaki, C Karabiyik, GJ Krause, A Lopez, ... Neuron 110 (6), 935-966, 2022 | 280 | 2022 |
Asymmetric epoxidation of electron-deficient olefins MJ Porter, J Skidmore Chemical Communications, 1215-1225, 2000 | 205 | 2000 |
Efficient asymmetric epoxidation of α, β-unsaturated ketones using a soluble triblock polyethylene glycol− polyamino acid catalyst RW Flood, TP Geller, SA Petty, SM Roberts, J Skidmore, M Volk Organic Letters 3 (5), 683-686, 2001 | 118 | 2001 |
Polyamino acids as catalysts in asymmetric synthesis MJ Porter, SM Roberts, J Skidmore Bioorganic & medicinal chemistry 7 (10), 2145-2156, 1999 | 101 | 1999 |
Total synthesis of (−)-nakadomarin A AF Kyle, P Jakubec, DM Cockfield, E Cleator, J Skidmore, DJ Dixon Chemical Communications 47 (36), 10037-10039, 2011 | 86 | 2011 |
Polyamino acid-catalysed asymmetric epoxidation: Sodium percarbonate as a source of base and oxidant JV Allen, KH Drauz, RW Flood, SM Roberts, J Skidmore Tetrahedron letters 40 (29), 5417-5420, 1999 | 77 | 1999 |
A detailed investigation of the aza-Prins reaction AP Dobbs, SJJ Guesné, RJ Parker, J Skidmore, RA Stephenson, ... Organic & Biomolecular Chemistry 8 (5), 1064-1080, 2010 | 75 | 2010 |
New procedures for the Juliß–Colonna asymmetric epoxidation: synthesis of (+)-clausenamide MW Cappi, RW Flood, SM Roberts, NM Williamson, JA Smith Chemical Communications, 1159-1160, 1998 | 71 | 1998 |
BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells P Beswick, N Charrier, B Clarke, E Demont, C Dingwall, R Dunsdon, ... Bioorganic & medicinal chemistry letters 18 (3), 1022-1026, 2008 | 69 | 2008 |
Systematic investigation of the permeability of androgen receptor PROTACs DE Scott, TPC Rooney, ED Bayle, T Mirza, HMG Willems, JH Clarke, ... ACS Medicinal Chemistry Letters 11 (8), 1539-1547, 2020 | 58 | 2020 |
Development of the Juliá− Colonna Asymmetric Epoxidation Reaction: Part 1. Preparation and Activation of the Polyleucine Catalyst S Baars, KH Drauz, HP Krimmer, SM Roberts, J Sander, J Skidmore, ... Organic process research & development 7 (4), 509-513, 2003 | 58 | 2003 |
3 α7 Nicotinic Acetylcholine Receptor Agonists and Positive Allosteric Modulators AP Lightfoot, JNC Kew, J Skidmore Progress in medicinal chemistry 46, 131-171, 2008 | 45 | 2008 |
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death DE Scott, NJ Francis-Newton, ME Marsh, AG Coyne, G Fischer, ... Cell chemical biology 28 (6), 835-847. e5, 2021 | 37 | 2021 |
Therapeutic inhibition of ferroptosis in neurodegenerative disease SK Ryan, CL Ugalde, AS Rolland, J Skidmore, D Devos, TR Hammond Trends in Pharmacological Sciences, 2023 | 36 | 2023 |
Rapid access to CF3-containing heterocycles AP Dobbs, RJ Parker, J Skidmore Tetrahedron Letters 49 (5), 827-831, 2008 | 36 | 2008 |
The effect of the primary structure of the polypeptide catalyst on the enantioselectivity of the Juliá–Colonna asymmetric epoxidation of enones PA Bentley, RW Flood, SM Roberts, J Skidmore, CB Smith, JA Smith Chemical Communications, 1616-1617, 2001 | 31 | 2001 |
β-Peptides as catalysts: poly-β-leucine as a catalyst for the Juliá–Colonna asymmetric epoxidation of enones PE Coffey, KH Drauz, SM Roberts, J Skidmore, JA Smith Chemical Communications, 2330-2331, 2001 | 30 | 2001 |
Biomimetic reactions in organic synthesis: Semi-pinacol rearrangements of some spirocyclic epoxyalcohols derived from Juliá-Colonna asymmetric epoxidations B Hauer, JF Bickley, J Massue, PCA Pena, SM Roberts, J Skidmore Canadian journal of chemistry 80 (6), 546-550, 2002 | 26 | 2002 |