| ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy Y Shi, K Yamada, SA Liddelow, ST Smith, L Zhao, W Luo, RM Tsai, ... Nature 549 (7673), 523-527, 2017 | 1019 | 2017 |
| A common haplotype lowers PU. 1 expression in myeloid cells and delays onset of Alzheimer's disease K Huang, E Marcora, AA Pimenova, AF Di Narzo, M Kapoor, SC Jin, ... Nature neuroscience 20 (8), 1052-1061, 2017 | 350 | 2017 |
| Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status L Piccio, Y Deming, JL Del-Águila, L Ghezzi, DM Holtzman, AM Fagan, ... Acta neuropathologica 131, 925-933, 2016 | 336 | 2016 |
| An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations U Dube, JL Del-Aguila, Z Li, JP Budde, S Jiang, S Hsu, L Ibanez, ... Nature neuroscience 22 (11), 1903-1912, 2019 | 274 | 2019 |
| The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk Y Deming, F Filipello, F Cignarella, C Cantoni, S Hsu, R Mikesell, Z Li, ... Science translational medicine 11 (505), eaau2291, 2019 | 226 | 2019 |
| Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers Y Deming, Z Li, M Kapoor, O Harari, JL Del-Aguila, K Black, D Carrell, ... Acta neuropathologica 133 (5), 839-856, 2017 | 213 | 2017 |
| Single-nuclei RNA sequencing from human brain to study for Mendelian and sporadic AD JL Del-Aguila, Z Li, U Dube, KA Mihindukulasuriya, JP Budde, ... bioRxiv, 593756, 2019 | 164* | 2019 |
| Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms C Cruchaga, JL Del-Aguila, B Saef, K Black, MV Fernandez, J Budde, ... Alzheimer's & Dementia 14 (2), 205-214, 2018 | 134 | 2018 |
| Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis BV Lananna, CA McKee, MW King, JL Del-Aguila, JM Dimitry, FHG Farias, ... Science translational medicine 12 (574), eaax3519, 2020 | 124 | 2020 |
| Sex-specific genetic predictors of Alzheimer’s disease biomarkers Y Deming, L Dumitrescu, LL Barnes, M Thambisetty, B Kunkle, KA Gifford, ... Acta neuropathologica 136, 857-872, 2018 | 92 | 2018 |
| TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers JL Del-Aguila, BA Benitez, Z Li, U Dube, KA Mihindukulasuriya, JP Budde, ... Molecular neurodegeneration 14, 1-13, 2019 | 77 | 2019 |
| Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels L Ibanez, U Dube, B Saef, J Budde, K Black, A Medvedeva, JL Del-Aguila, ... BMC neurology 17, 1-9, 2017 | 68 | 2017 |
| The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion Z Li, FHG Farias, U Dube, JL Del-Aguila, KA Mihindukulasuriya, ... Acta neuropathologica 139 (1), 45-61, 2020 | 62 | 2020 |
| Assessment of the genetic architecture of Alzheimer’s disease risk in rate of memory decline JL Del-Aguila, MV Fernández, S Schindler, L Ibanez, Y Deming, S Ma, ... Journal of Alzheimer's Disease 62 (2), 745-756, 2018 | 62 | 2018 |
| Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure Z Li, JL Del-Aguila, U Dube, J Budde, R Martinez, K Black, Q Xiao, ... Genome medicine 10, 1-19, 2018 | 55 | 2018 |
| Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging Q Yan, K Nho, JL Del-Aguila, X Wang, SL Risacher, KH Fan, BE Snitz, ... Molecular psychiatry 26 (1), 309-321, 2021 | 54 | 2021 |
| Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP S Jiang, N Wen, Z Li, U Dube, J Del Aguila, J Budde, R Martinez, S Hsu, ... Translational psychiatry 8 (1), 265, 2018 | 54 | 2018 |
| Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans JL Del-Aguila, AL Beitelshees, RM Cooper-Dehoff, AB Chapman, ... The pharmacogenomics journal 14 (1), 35-40, 2014 | 52 | 2014 |
| Alzheimer's disease: rare variants with large effect sizes JL Del-Aguila, DC Koboldt, K Black, R Chasse, J Norton, RK Wilson, ... Current opinion in genetics & development 33, 49-55, 2015 | 49 | 2015 |
| Genome‐wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways R Sherva, A Gross, S Mukherjee, R Koesterer, P Amouyel, C Bellenguez, ... Alzheimer's & Dementia 16 (8), 1134-1145, 2020 | 35 | 2020 |
Carlos CruchagaProfessor. NeuroGenomics and Informatics Center Director在 wustl.edu 的电子邮件经过验证
