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A basophil-neuronal axis promotes itch
F Wang, AM Trier, F Li, S Kim, Z Chen, JN Chai, MR Mack, SA Morrison, ...
Cell 184 (2), 422-440. e17, 2021
1532021
TRP channels as drug targets to relieve itch
Z Xie, H Hu
Pharmaceuticals 11 (4), 100, 2018
812018
TRPV4 channel signaling in macrophages promotes gastrointestinal motility via direct effects on smooth muscle cells
J Luo, A Qian, LK Oetjen, W Yu, P Yang, J Feng, Z Xie, S Liu, S Yin, ...
Immunity 49 (1), 107-119. e4, 2018
722018
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection
W Zhang, M Lyu, NJ Bessman, Z Xie, M Arifuzzaman, H Yano, ...
Cell 185 (22), 4170-4189. e20, 2022
552022
Gating of human TRPV3 in a lipid bilayer
Z Deng, G Maksaev, M Rau, Z Xie, H Hu, JAJ Fitzpatrick, P Yuan
Nature Structural & Molecular Biology 27 (7), 635-644, 2020
532020
Scorpion potassium channel-blocking defensin highlights a functional link with neurotoxin
L Meng, Z Xie, Q Zhang, Y Li, F Yang, Z Chen, W Li, Z Cao, Y Wu
Journal of biological chemistry 291 (13), 7097-7106, 2016
462016
Endogenous animal toxin-like human β-defensin 2 inhibits own K+ channels through interaction with channel extracellular pore region
W Yang, J Feng, F Xiang, Z Xie, G Zhang, JM Sabatier, Z Cao, W Li, ...
Cellular and molecular life sciences 72, 845-853, 2015
422015
Mechanosensitive TRPV4 is required for crystal-induced inflammation
Z Lan, L Chen, J Feng, Z Xie, Z Liu, F Wang, P Liu, X Yue, L Du, Y Zhao, ...
Annals of the rheumatic diseases 80 (12), 1604-1614, 2021
412021
A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain
X Hu, L Du, S Liu, Z Lan, K Zang, J Feng, Y Zhao, X Yang, Z Xie, PL Wang, ...
The Journal of Clinical Investigation 133 (5), 2023
332023
Plectasin, first animal toxin-like fungal defensin blocking potassium channels through recognizing channel pore region
F Xiang, Z Xie, J Feng, W Yang, Z Cao, W Li, Z Chen, Y Wu
Toxins 7 (1), 34-42, 2015
332015
Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1. 3 channel
Z Chen, Y Hu, J Hong, J Hu, W Yang, F Xiang, F Yang, Z Xie, Z Cao, W Li, ...
Scientific reports 5 (1), 9881, 2015
312015
Human α‐defensins are immune‐related Kv1. 3 channel inhibitors: new support for their roles in adaptive immunity
Z Xie, J Feng, W Yang, F Xiang, F Yang, Y Zhao, Z Cao, W Li, Z Chen, ...
The FASEB Journal 29 (10), 4324-4333, 2015
272015
Anti-inflammatory dopamine-and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel
WR Arnold, LN Carnevale, Z Xie, JL Baylon, E Tajkhorshid, H Hu, A Das
Nature communications 12 (1), 926, 2021
262021
The scorpion toxin analogue BmKTX-D33H as a potential Kv1. 3 channel-selective immunomodulator for autoimmune diseases
F Ye, Y Hu, W Yu, Z Xie, J Hu, Z Cao, W Li, Y Wu
Toxins 8 (4), 115, 2016
262016
Kir6. 1-and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome
NW York, H Parker, Z Xie, D Tyus, MA Waheed, Z Yan, DK Grange, ...
JCI insight 5 (23), 2020
192020
Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity
Z Xie, J Feng, TJ Hibberd, BN Chen, Y Zhao, K Zang, X Hu, X Yang, ...
Neuron 111 (4), 526-538. e4, 2023
182023
Kv channel S1-S2 linker working as a binding site of human β-defensin 2 for channel activation modulation
J Feng, W Yang, Z Xie, F Xiang, Z Cao, W Li, H Hu, Z Chen, Y Wu
Journal of Biological Chemistry 290 (25), 15487-15495, 2015
162015
Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle
J Feng, Y Zhao, Z Xie, K Zang, S Sviben, X Hu, JAJ Fitzpatrick, L Wen, ...
Science translational medicine 14 (653), eabn4819, 2022
142022
Kir2. 1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters
W Yu, Z Wang, X Yu, Y Zhao, Z Xie, K Zhang, Z Chi, S Chen, T Xu, ...
Nature communications 13 (1), 3544, 2022
142022
Human beta-defensin 1, a new animal toxin-like blocker of potassium channel
J Feng, Z Xie, W Yang, Y Zhao, F Xiang, Z Cao, W Li, Z Chen, Y Wu
Toxicon 113, 1-6, 2016
102016
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