Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas PJ Killela, CJ Pirozzi, P Healy, ZJ Reitman, E Lipp, BA Rasheed, R Yang, ... Oncotarget 5 (6), 1515, 2014 | 297 | 2014 |
Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation DS Huang, Z Wang, XJ He, BH Diplas, R Yang, PJ Killela, Q Meng, ZY Ye, ... European Journal of Cancer 51 (8), 969-976, 2015 | 212 | 2015 |
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas L Zhang, LH Chen, H Wan, R Yang, Z Wang, J Feng, S Yang, S Jones, ... Nature genetics 46 (7), 726-730, 2014 | 184 | 2014 |
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma BH Diplas, X He, JA Brosnan-Cashman, H Liu, LH Chen, Z Wang, ... Nature communications 9 (1), 2087, 2018 | 155 | 2018 |
Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases Z Wang, J Zhang, Y Wang, R Xing, C Yi, H Zhu, X Chen, J Guo, W Guo, ... Carcinogenesis 34 (1), 128-138, 2013 | 86 | 2013 |
Patient-derived micro-organospheres enable clinical precision oncology S Ding, C Hsu, Z Wang, NR Natesh, R Millen, M Negrete, N Giroux, ... Cell Stem Cell 29 (6), 905-917. e6, 2022 | 78 | 2022 |
Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells R Xing, W Li, J Cui, J Zhang, B Kang, Y Wang, Z Wang, S Liu, Y Lu Gut 61 (1), 43-52, 2012 | 77 | 2012 |
Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities MS Waitkus, CJ Pirozzi, CJ Moure, BH Diplas, LJ Hansen, AB Carpenter, ... Cancer research 78 (1), 36-50, 2018 | 42 | 2018 |
Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors C Xu, X Liu, Y Geng, Q Bai, C Pan, Y Sun, X Chen, H Yu, Y Wu, P Zhang, ... Oncotarget 8 (44), 76644, 2017 | 29 | 2017 |
Targeting mutant PPM1D sensitizes diffuse intrinsic pontine glioma cells to the PARP inhibitor olaparib Z Wang, C Xu, BH Diplas, CJ Moure, CPJ Chen, LH Chen, C Du, H Zhu, ... Molecular Cancer Research 18 (7), 968-980, 2020 | 26 | 2020 |
CRISPR editing of mutant IDH1 R132H induces a CpG methylation-low state in patient-derived glioma models of G-CIMP CJ Moure, BH Diplas, LH Chen, R Yang, CJ Pirozzi, Z Wang, I Spasojevic, ... Molecular Cancer Research 17 (10), 2042-2050, 2019 | 21 | 2019 |
Rapid tissue prototyping with micro-organospheres Z Wang, M Boretto, R Millen, N Natesh, ES Reckzeh, C Hsu, M Negrete, ... Stem cell reports 17 (9), 1959-1975, 2022 | 15 | 2022 |
mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances X Chen, Y Zhu, Z Wang, H Zhu, Q Pan, S Su, Y Dong, L Li, H Zhang, L Wu, ... Journal of proteomics 136, 13-24, 2016 | 13 | 2016 |
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal H Yan, PJ Killela, ZJ Reitman, Y Jiao, C Bettegowda, N Agrawal, ... Neuro-Oncology 16 (suppl_3), iii5-iii6, 2014 | 4 | 2014 |
Micro-organospheres: An automated patient-derived model platform for rapid drug screening of breast cancer. Z Wang, E Cortes-Sanchez, CH Yang, D Nelson, D Delubac, SD Hsu, ... Journal of Clinical Oncology 39 (15_suppl), e12628-e12628, 2021 | 3 | 2021 |
Methods and apparatuses for purification of gel droplets supporting biological tissue Z Wang, X Shen US Patent 11,628,382, 2023 | 2 | 2023 |
Methods and apparatuses for patient-derived micro-organospheres X Shen, D Hsu, J Motschman, D Delubac, Z Wang US Patent 11,555,180, 2023 | 2 | 2023 |
Patient-derived micro-organospheres recapitulate tumor microenvironment and heterogeneity for precision oncology. S Ding, Z Wang, MN Obando, G Palomino, T Rotstein, I Williamson, ... Journal of Clinical Oncology 39 (15_suppl), 3076-3076, 2021 | 2 | 2021 |
Identification and elimination of heterophilic antibody interference during antibody pair screening Y Wang, H Wei, Q Pan, Z Wang, R Xing, W Li, J Zhang, M Ding, J Guo, ... Analytical biochemistry 430 (1), 1-3, 2012 | 2 | 2012 |
Chromatin Remodeling in Patient‐Derived Colorectal Cancer Models K Xiang, E Wang, J Mantyh, G Rupprecht, M Negrete, G Sanati, C Hsu, ... Advanced Science 11 (16), 2303379, 2024 | 1 | 2024 |