Epithelial Na+ channels are fully activated by furin-and prostasin-dependent release of an inhibitory peptide from the γ-subunit JB Bruns, MD Carattino, S Sheng, AB Maarouf, OA Weisz, JM Pilewski, ... Journal of Biological Chemistry 282 (9), 6153-6160, 2007 | 357 | 2007 |
Subunit stoichiometry of the epithelial sodium channel F Kosari, S Sheng, J Li, DOD Mak, JK Foskett, TR Kleyman Journal of Biological Chemistry 273 (22), 13469-13474, 1998 | 277 | 1998 |
Epithelial Na+ channels are regulated by flow LM Satlin, S Sheng, CB Woda, TR Kleyman American Journal of Physiology-Renal Physiology 280 (6), F1010-F1018, 2001 | 245 | 2001 |
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition S Sheng, MD Carattino, JB Bruns, RP Hughey, TR Kleyman American Journal of Physiology-Renal Physiology 290 (6), F1488-F1496, 2006 | 204 | 2006 |
Epithelial Na+ channels are activated by laminar shear stress MD Carattino, S Sheng, TR Kleyman Journal of Biological Chemistry 279 (6), 4120-4126, 2004 | 184 | 2004 |
The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its α subunit MD Carattino, S Sheng, JB Bruns, JM Pilewski, RP Hughey, TR Kleyman Journal of Biological Chemistry 281 (27), 18901-18907, 2006 | 179 | 2006 |
Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells DG Warnock, K Kusche-Vihrog, A Tarjus, S Sheng, H Oberleithner, ... Nature Reviews Nephrology 10 (3), 146-157, 2014 | 130 | 2014 |
Characterization of the selectivity filter of the epithelial sodium channel S Sheng, J Li, KA McNulty, D Avery, TR Kleyman Journal of Biological Chemistry 275 (12), 8572-8581, 2000 | 109 | 2000 |
Extracellular histidine residues crucial for Na+ self-inhibition of epithelial Na+ channels S Sheng, JB Bruns, TR Kleyman Journal of Biological Chemistry 279 (11), 9743-9749, 2004 | 93 | 2004 |
External nickel inhibits epithelial sodium channel by binding to histidine residues within the extracellular domains of α and γ subunits and reducing channel open probability S Sheng, CJ Perry, TR Kleyman Journal of Biological Chemistry 277 (51), 50098-50111, 2002 | 86 | 2002 |
Epithelial sodium channel pore region: structure and role in gating S Sheng, J Li, KA McNulty, T Kieber-Emmons, TR Kleyman Journal of Biological Chemistry 276 (2), 1326-1334, 2001 | 81 | 2001 |
Mutations in the pore region modify epithelial sodium channel gating by shear stress MD Carattino, S Sheng, TR Kleyman Journal of Biological Chemistry 280 (6), 4393-4401, 2005 | 79 | 2005 |
Extracellular Zn2+ activates epithelial Na+ channels by eliminating Na+ self-inhibition S Sheng, CJ Perry, TR Kleyman Journal of Biological Chemistry 279 (30), 31687-31696, 2004 | 73 | 2004 |
Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition S Sheng, AB Maarouf, JB Bruns, RP Hughey, TR Kleyman Journal of Biological Chemistry 282 (28), 20180-20190, 2007 | 71 | 2007 |
Functional polymorphism in the carboxyl terminus of the α-subunit of the human epithelial sodium channel FF Samaha, RC Rubenstein, W Yan, M Ramkumar, DI Levy, YJ Ahn, ... Journal of Biological Chemistry 279 (23), 23900-23907, 2004 | 57 | 2004 |
Second transmembrane domains of ENaC subunits contribute to ion permeation and selectivity S Sheng, KA McNulty, JM Harvey, TR Kleyman Journal of Biological Chemistry 276 (47), 44091-44098, 2001 | 56 | 2001 |
Novel determinants of epithelial sodium channel gating within extracellular thumb domains AB Maarouf, N Sheng, J Chen, KL Winarski, S Okumura, MD Carattino, ... Journal of Biological Chemistry 284 (12), 7756-7765, 2009 | 54 | 2009 |
On the interaction between amiloride and its putative α-subunit epithelial Na+ channel binding site OB Kashlan, S Sheng, TR Kleyman Journal of Biological Chemistry 280 (28), 26206-26215, 2005 | 53 | 2005 |
Base of the thumb domain modulates epithelial sodium channel gating S Shi, DD Ghosh, S Okumura, MD Carattino, OB Kashlan, S Sheng, ... Journal of Biological Chemistry 286 (17), 14753-14761, 2011 | 51 | 2011 |
Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels S Sheng, CJ Perry, OB Kashlan, TR Kleyman Journal of Biological Chemistry 280 (9), 8513-8522, 2005 | 42 | 2005 |