| Development of 3, 5-dinitrophenyl-containing 1, 2, 4-triazoles and their trifluoromethyl analogues as highly efficient antitubercular agents inhibiting decaprenylphosphoryl-β-d … G Karabanovich, J Dušek, K Savková, O Pavliš, I Pávková, ... Journal of Medicinal Chemistry 62 (17), 8115-8139, 2019 | 58 | 2019 |
| Novel tacrine-scutellarin hybrids as multipotent anti-Alzheimer’s agents: Design, synthesis and biological evaluation K Spilovska, J Korabecny, V Sepsova, D Jun, M Hrabinova, P Jost, ... Molecules 22 (6), 1006, 2017 | 53 | 2017 |
| Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity E Kohelová, J Maříková, J Korábečný, D Hulcová, T Kučera, D Jun, ... Bioorganic chemistry 107, 104567, 2021 | 49 | 2021 |
| Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase A Al Mamun, J Maříková, D Hulcová, J Janoušek, M Šafratová, ... Biomolecules 10 (5), 800, 2020 | 48 | 2020 |
| Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006–2016) L Gorecki, J Korabecny, K Musilek, E Nepovimova, D Malinak, T Kucera, ... Expert opinion on therapeutic patents 27 (9), 971-985, 2017 | 48 | 2017 |
| In vitro and in silico acetylcholinesterase inhibitory activity of thalictricavine and canadine and their predicted penetration across the blood-brain barrier J Chlebek, J Korábečný, R Doležal, Š Štěpánková, DI Pérez, ... Molecules 24 (7), 1340, 2019 | 43 | 2019 |
| Derivatives of the β-crinane Amaryllidaceae alkaloid haemanthamine as multi-target directed ligands for Alzheimer’s disease E Kohelová, R Peřinová, N Maafi, J Korábečný, D Hulcová, J Maříková, ... Molecules 24 (7), 1307, 2019 | 43 | 2019 |
| (±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel … L Ismaili, J Monnin, A Etievant, RL Arribas, L Viejo, B Refouvelet, ... ACS Chemical Neuroscience 12 (8), 1328-1342, 2021 | 38 | 2021 |
| Aromatic esters of the crinane Amaryllidaceae alkaloid ambelline as selective inhibitors of butyrylcholinesterase J Maríkova, A Ritomska, J Korabecny, R Perinova, A Al Mamun, T Kucera, ... Journal of natural products 83 (5), 1359-1367, 2020 | 35 | 2020 |
| Tacrine–Benzothiazoles: Novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems E Nepovimova, L Svobodova, R Dolezal, V Hepnarova, L Junova, D Jun, ... Bioorganic Chemistry 107, 104596, 2021 | 29 | 2021 |
| Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile K Sobolova, M Hrabinova, V Hepnarova, T Kucera, T Kobrlova, ... European journal of medicinal chemistry 203, 112593, 2020 | 28 | 2020 |
| Structure–activity relationship study of dexrazoxane analogues reveals ICRF-193 as the most potent bisdioxopiperazine against anthracycline toxicity to cardiomyocytes due to … A Jirkovská, G Karabanovich, J Kubes, V Skalická, I Melnikova, ... Journal of medicinal chemistry 64 (7), 3997-4019, 2021 | 25 | 2021 |
| Structure elucidation and cholinesterase inhibition activity of two new minor Amaryllidaceae alkaloids J Maříková, AA Mamun, LA Shammari, J Korábečný, T Kučera, D Hulcová, ... Molecules 26 (5), 1279, 2021 | 22 | 2021 |
| Is it the twilight of BACE1 inhibitors? M Hrabinova, J Pejchal, T Kucera, D Jun, M Schmidt, O Soukup Current Neuropharmacology 19 (1), 61-77, 2021 | 21 | 2021 |
| Oxime K203: a drug candidate for the treatment of tabun intoxication L Gorecki, O Soukup, T Kucera, D Malinak, D Jun, K Kuca, K Musilek, ... Archives of Toxicology 93, 673-691, 2019 | 21 | 2019 |
| Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells J Tenhunen, T Kučera, M Huovinen, J Küblbeck, E Bisenieks, B Vigante, ... Biomedicine & Pharmacotherapy 138, 111452, 2021 | 18 | 2021 |
| 7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo M Kaniakova, J Korabecny, K Holubova, L Kleteckova, M Chvojkova, ... Biochemical Pharmacology 186, 114460, 2021 | 18 | 2021 |
| Monoterpene indole alkaloids from Vinca minor L.(Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease R Vrabec, J Maříková, M Ločárek, J Korábečný, D Hulcová, A Hošťálková, ... Phytochemistry 194, 113017, 2022 | 17 | 2022 |
| Amaryllidaceae alkaloids of norbelladine-type as inspiration for development of highly selective butyrylcholinesterase inhibitors: Synthesis, biological activity evaluation … AA Mamun, F Pidaný, D Hulcová, J Maříková, T Kučera, M Schmidt, ... International Journal of Molecular Sciences 22 (15), 8308, 2021 | 16 | 2021 |
| Impact of maternal diabetes type 1 on proliferative potential, differentiation and apoptotic activity in villous capillaries of term placenta M Jirkovská, T Kučera, V Dvořáková, M Jadrníček, M Moravcová, Z Žižka, ... Placenta 40, 1-7, 2016 | 16 | 2016 |
