Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling D Willoughby, KL Everett, ML Halls, J Pacheco, P Skroblin, L Vaca, ... Science signaling 5 (219), ra29-ra29, 2012 | 139 | 2012 |
A high-avidity biosensor reveals plasma membrane PI(3,4)P2 is predominantly a class I PI3K signaling product BD Goulden, J Pacheco, A Dull, JP Zewe, A Deiters, GRV Hammond Journal of Cell Biology 218 (3), 1066-1079, 2019 | 110 | 2019 |
The P2X7/P2X4 interaction shapes the purinergic response in murine macrophages G Pérez-Flores, SA Lévesque, J Pacheco, L Vaca, S Lacroix, ... Biochemical and biophysical research communications 467 (3), 484-490, 2015 | 68 | 2015 |
A cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions J Pacheco, L Dominguez, A Bohórquez-Hernández, A Asanov, L Vaca Scientific reports 6 (1), 29634, 2016 | 65 | 2016 |
Combined single channel and single molecule detection identifies subunit composition of STIM1-activated transient receptor potential canonical (TRPC) channels A Asanov, A Sampieri, C Moreno, J Pacheco, A Salgado, R Sherry, ... Cell Calcium 57 (1), 1-13, 2015 | 43 | 2015 |
Cholesterol modulates the cellular localization of Orai1 channels and its disposition among membrane domains A Bohórquez-Hernández, E Gratton, J Pacheco, A Asanov, L Vaca Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2017 | 38 | 2017 |
Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu LJ Ayling, SJ Briddon, ML Halls, GRV Hammond, L Vaca, J Pacheco, ... Journal of cell science 125 (4), 869-886, 2012 | 36 | 2012 |
Orai3 channel is the 2-APB-induced endoplasmic reticulum calcium leak D Leon-Aparicio, J Pacheco, J Chavez-Reyes, JM Galindo, J Valdes, ... Cell Calcium 65, 91-101, 2017 | 28 | 2017 |
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase GFW Walpole, J Pacheco, N Chauhan, J Clark, KE Anderson, YM Abbas, ... Nature cell biology 24 (5), 708-722, 2022 | 24 | 2022 |
Lysosomal inhibition sensitizes TMEM16A-expressing cancer cells to chemotherapy A Vyas, R Gomez-Casal, S Cruz-Rangel, H Villanueva, AG Sikora, ... Proceedings of the National Academy of Sciences 119 (12), e2100670119, 2022 | 21 | 2022 |
Heterologous calcium-dependent inactivation of Orai1 by neighboring TRPV1 channels modulates cell migration and wound healing CE Bastián-Eugenio, A Bohórquez-Hernández, J Pacheco, A Sampieri, ... Communications Biology 2 (1), 88, 2019 | 20 | 2019 |
PI(4,5)P2 diffuses freely in the plasma membrane even within high-density effector protein complexes J Pacheco, AC Cassidy, JP Zewe, RC Wills, GRV Hammond Journal of Cell Biology 222 (2), e202204099, 2022 | 17 | 2022 |
A novel homeostatic mechanism tunes PI (4, 5) P2-dependent signaling at the plasma membrane RC Wills, CP Doyle, JP Zewe, J Pacheco, SD Hansen, GRV Hammond Journal of Cell Science 136 (16), 2023 | 12 | 2023 |
Quantification of genetically encoded lipid biosensors RC Wills, J Pacheco, GRV Hammond Phosphoinositides: Methods and Protocols, 55-72, 2021 | 11 | 2021 |
Microdomains associated to lipid rafts J Pacheco, JO Ramírez-Jarquín, L Vaca Calcium Entry Pathways in Non-excitable Cells, 353-378, 2016 | 10 | 2016 |
Phosphorylation of NMDA receptors by cyclin B/CDK1 modulates calcium dynamics and mitosis MJ Rosendo-Pineda, JJ Vicente, O Vivas, J Pacheco, A Loza-Huerta, ... Communications Biology 3 (1), 665, 2020 | 9 | 2020 |
STIM-TRP pathways and microdomain organization: auxiliary proteins of the STIM/orai complex J Pacheco, L Vaca Store-Operated Ca²⁺ Entry (SOCE) Pathways: Emerging Signaling Concepts in …, 2017 | 9 | 2017 |
Oxysterol binding protein: Tether, transporter… and flux capacitor? GRV Hammond, J Pacheco Trends in Cell Biology 29 (7), 531-533, 2019 | 4 | 2019 |
A Microscopic View of the Store‐Operated Calcium Entry‐Pathway J Pacheco, L Vaca International Scholarly Research Notices 2013 (1), 237192, 2013 | 3 | 2013 |
Induced dimerization tools to deplete specific phosphatidylinositol phosphates J Pacheco, RC Wills, GRV Hammond Phosphoinositides: Methods and Protocols, 105-120, 2021 | 2 | 2021 |