Lipocalin 2 protects from inflammation and tumorigenesis associated with gut microbiota alterations AR Moschen, RR Gerner, J Wang, V Klepsch, TE Adolph, SJ Reider, ... Cell host & microbe 19 (4), 455-469, 2016 | 301 | 2016 |
Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution M Efremova, D Rieder, V Klepsch, P Charoentong, F Finotello, H Hackl, ... Nature communications 9 (1), 32, 2018 | 272 | 2018 |
NAD metabolism fuels human and mouse intestinal inflammation RR Gerner, V Klepsch, S Macheiner, K Arnhard, TE Adolph, C Grander, ... Gut 67 (10), 1813-1823, 2018 | 133 | 2018 |
Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade V Klepsch, N Hermann-Kleiter, P Do-Dinh, B Jakic, A Offermann, ... Nature communications 9 (1), 1538, 2018 | 56 | 2018 |
Nuclear receptors regulate intestinal inflammation in the context of IBD V Klepsch, AR Moschen, H Tilg, G Baier, N Hermann-Kleiter Frontiers in immunology 10, 1070, 2019 | 53 | 2019 |
The nuclear orphan receptor NR2F6 is a central checkpoint for cancer immune surveillance N Hermann-Kleiter, V Klepsch, S Wallner, K Siegmund, S Klepsch, ... Cell reports 12 (12), 2072-2085, 2015 | 50 | 2015 |
The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland F Schuler, F Baumgartner, V Klepsch, M Chamson, E Müller-Holzner, ... Cell Death & Differentiation 23 (1), 41-51, 2016 | 36 | 2016 |
Nuclear orphan receptor NR2F6 as a safeguard against experimental murine colitis V Klepsch, RR Gerner, S Klepsch, WJ Olson, H Tilg, AR Moschen, G Baier, ... Gut 67 (8), 1434-1444, 2018 | 28 | 2018 |
Orphan nuclear receptor NR2F6 suppresses T follicular helper cell accumulation through regulation of IL-21 WJ Olson, B Jakic, V Labi, K Schoeler, M Kind, V Klepsch, G Baier, ... Cell reports 28 (11), 2878-2891. e5, 2019 | 24 | 2019 |
Beyond CTLA-4 and PD-1: orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy V Klepsch, N Hermann-Kleiter, G Baier Immunology letters 178, 31-36, 2016 | 22 | 2016 |
Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy V Klepsch, M Pommermayr, D Humer, N Brigo, N Hermann-Kleiter, ... Cell Communication and Signaling 18, 1-12, 2020 | 18 | 2020 |
Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice C Pfeifhofer-Obermair, K Albrecht-Schgoer, S Peer, M Nairz, K Siegmund, ... Cell Communication and Signaling 14, 1-8, 2016 | 17 | 2016 |
Emerging next-generation target for cancer immunotherapy research: The orphan nuclear receptor NR2F6 V Klepsch, K Siegmund, G Baier Cancers 13 (11), 2600, 2021 | 15 | 2021 |
Loss of the orphan nuclear receptor NR2F6 enhances CD8+ T-cell memory via IFN-γ B Jakic, WJ Olson, K Siegmund, V Klepsch, J Kimpel, V Labi, D Zehn, ... Cell death & disease 12 (2), 187, 2021 | 13 | 2021 |
Proof of principle for a T lymphocyte intrinsic function of Coronin 1A K Siegmund, V Klepsch, N Hermann-Kleiter, G Baier Journal of Biological Chemistry 291 (42), 22086-22092, 2016 | 13 | 2016 |
Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution. Nat Commun. 2018; 9 (1): 32 M Efremova, D Rieder, V Klepsch, P Charoentong, F Finotello, H Hackl, ... | 13 | |
Iron supplementation interferes with immune therapy of murine mammary carcinoma by inhibiting anti-tumor T cell function P Tymoszuk, M Nairz, N Brigo, V Petzer, S Heeke, B Kircher, ... Frontiers in Oncology 10, 584477, 2020 | 12 | 2020 |
Loss-of-function phenotype of a PKCθT219A knockin mouse strain N Thuille, K Siegmund, V Klepsch, J Schörgenhuber, S Danklmaier, ... Cell Communication and Signaling 17, 1-11, 2019 | 5 | 2019 |
A MLR-based approach to analyze regulators of T lymphocyte activation in vivo J Koutník, V Klepsch, M Pommermayr, N Thuille, G Baier, K Siegmund International Journal of Molecular Sciences 23 (10), 5337, 2022 | 4 | 2022 |
Melanoma-intrinsic NR2F6 activity regulates antitumor immunity H Kim, Y Feng, R Murad, J Pozniak, C Pelz, Y Chen, B Dalal, R Sears, ... Science Advances 9 (27), eadf6621, 2023 | 3 | 2023 |