Efficient single-strand break repair requires binding to both poly (ADP-ribose) and DNA by the central BRCT domain of XRCC1 LM Polo, Y Xu, P Hornyak, F Garces, Z Zeng, R Hailstone, SJ Matthews, ... Cell reports 26 (3), 573-581. e5, 2019 | 81 | 2019 |
PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2 GJ Grundy, LM Polo, Z Zeng, SL Rulten, NC Hoch, P Paomephan, Y Xu, ... Nature Communications 7 (1), 12404, 2016 | 81 | 2016 |
Specialized interfaces of Smc5/6 control hinge stability and DNA association A Alt, HQ Dang, OS Wells, LM Polo, MA Smith, GA McGregor, T Welte, ... Nature communications 8 (1), 14011, 2017 | 80 | 2017 |
The Gene Cluster for Agmatine Catabolism of Enterococcus faecalis: Study of Recombinant Putrescine Transcarbamylase and Agmatine Deiminase and a … JL Llácer, LM Polo, S Tavárez, B Alarcón, R Hilario, V Rubio Journal of bacteriology 189 (4), 1254-1265, 2007 | 79 | 2007 |
Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis S de Cima, LM Polo, C Díez-Fernández, AI Martínez, J Cervera, I Fita, ... Scientific Reports 5 (1), 16950, 2015 | 75 | 2015 |
ADP-ribosylation: from molecular mechanisms to human disease NC Hoch, LM Polo Genetics and Molecular Biology 43, e20190075, 2019 | 52 | 2019 |
The crystal structure of the cephalosporin deacetylating enzyme acetyl xylan esterase bound to paraoxon explains the low sensitivity of this serine hydrolase to organophosphate … S Montoro-García, F Gil-Ortiz, F García-Carmona, LM Polo, V Rubio, ... Biochemical Journal 436 (2), 321-330, 2011 | 27 | 2011 |
New insight into the transcarbamylase family: the structure of putrescine transcarbamylase, a key catalyst for fermentative utilization of agmatine LM Polo, F Gil-Ortiz, A Cantin, V Rubio PLoS One 7 (2), e31528, 2012 | 9 | 2012 |
A lung-specific mutational signature enables inference of viral and bacterial respiratory niche C Ruis, TP Peacock, LM Polo, D Masone, MS Alvarez, AS Hinrichs, ... Microbial Genomics 9 (5), 001018, 2023 | 8 | 2023 |
Repurposing carvedilol as a novel inhibitor of the Trypanosoma cruzi autophagy flux that affects parasite Replication and survival CV Rivero, SJ Martínez, P Novick, JA Cueto, BN Salassa, MC Vanrell, X Li, ... Frontiers in cellular and infection microbiology 11, 657257, 2021 | 8 | 2021 |
Mutational spectra distinguish SARS-CoV-2 replication niches C Ruis, TP Peacock, LM Polo, D Masone, M Soledad Alvarez, AS Hinrichs, ... bioRxiv, 2022.09. 27.509649, 2022 | 6 | 2022 |
Expression, purification and application of a recombinant, membrane permeating version of the light chain of botulinum toxin B MV Buzzatto, FC Benegas Guerrero, PA Álvarez, MP Zizzias, LM Polo, ... Bioscience Reports 44 (7), BSR20240117, 2024 | | 2024 |
Myomerger Induces Membrane Hemifusion and Regulates Fusion Pore Expansion AL Di Bartolo, M Caparotta, LM Polo, D Masone Biochemistry 63 (6), 815-826, 2024 | | 2024 |
The SARS-CoV-2 mutation landscape is shaped before replication starts D Masone, MS Alvarez, LM Polo Genetics and Molecular Biology 46 (2), e20230005, 2023 | | 2023 |
Patología molecular y cristalografía de rayos X arrojan nueva luz sobre estructura-función de la carbamil fosfato sintetasa 1 humana (CPS1)(G01 35 P 027) N Gougeard, C Díez-Fernández, S Cima, LM Polo, C Marco-Marín, I Fita, ... | | 2022 |
Deciphering carbamoyl phosphate synthetase (CPS1) deficiency and urea cycle regulation by determining the structures of human CPS1 in the absence and in the presence of N … S Cima, LM Polo, C Díez-Fernández, AI Martínez, J Cervera, I Fita, ... | | 2016 |
New structural insights into PARP3 function LM Polo, G Grundy, S Rulten, Y Xu, S Matthews, K Caldecot, A Oliver, ... FEBS JOURNAL 282, 397-397, 2015 | | 2015 |
Crystal structures of human carbamoyl phosphate synthetase 1 (CPS1) shed light on domains functions, substrate tunnels and allosteric activation, and allow rationalization of … S Cima, LM Polo, C Díez-Fernández, J Cervera, I Fita, V Rubio Sociedad Española de Bioquímica y Biología Molecular, 2014 | | 2014 |
Human carbamoyl phosphate synthetase: structure, function and pathology: TUE-420 V Rubio, S De Cima, L Polo, C Díez-Fernández, J Cervera, I Fita The Febs Journal 281, 571-572, 2014 | | 2014 |
Looking at Metabolic Regulation and Inborn Errors from a Structural Viewpoint: a Urea Cycle Example S Cima, LM Polo, C Díez-Fernández, J Cervera, I Fita, V Rubio | | 2014 |