| Engineering a multifunctional nitroreductase for improved activation of prodrugs and PET probes for cancer gene therapy JN Copp, AM Mowday, EM Williams, CP Guise, A Ashoorzadeh, ... Cell Chemical Biology 24 (3), 391-403, 2017 | 76 | 2017 |
| NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation AV Sharrock, TS Mulligan, KR Hall, EM Williams, DT White, L Zhang, ... Nature methods 19 (2), 205-215, 2022 | 40 | 2022 |
| Lamellarin Sulfates from the Pacific Tunicate Didemnum ternerratum J Bracegirdle, LP Robertson, PA Hume, MJ Page, AV Sharrock, ... Journal of natural products 82 (7), 2000-2008, 2019 | 34 | 2019 |
| VapC proteins from Mycobacterium tuberculosis share ribonuclease sequence specificity but differ in regulation and toxicity A Sharrock, A Ruthe, ESV Andrews, VA Arcus, JL Hicks PloS one 13 (8), e0203412, 2018 | 25 | 2018 |
| Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa L Zhang, C Chen, J Fu, B Lilley, C Berlinicke, B Hansen, D Ding, G Wang, ... Elife 10, e57245, 2021 | 17 | 2021 |
| Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway LJ Stevenson, J Bracegirdle, L Liu, AV Sharrock, DF Ackerley, ... RSC Chemical Biology 2 (2), 556-567, 2021 | 17 | 2021 |
| Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui J Bracegirdle, LJ Stevenson, AV Sharrock, MJ Page, JA Vorster, JG Owen, ... Journal of Natural Products 84 (2), 544-547, 2021 | 14 | 2021 |
| U-2012: An improved Lowry protein assay, insensitive to sample color, offering reagent stability and enhanced sensitivity GC Upreti, Y Wang, A Finn, A Sharrock, N Feisst, M Davy, RB Jordan Biotechniques 52 (3), 159-166, 2012 | 14 | 2012 |
| Structure and function of AmtR in Mycobacterium smegmatis: implications for post-transcriptional regulation of urea metabolism through a small antisense RNA M Petridis, C Vickers, J Robson, JL McKenzie, M Bereza, A Sharrock, ... Journal of molecular biology 428 (21), 4315-4329, 2016 | 13 | 2016 |
| Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and … MH Rich, AV Sharrock, KR Hall, DF Ackerley, JK MacKichan Biotechnology letters 40, 359-367, 2018 | 12 | 2018 |
| Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System AV Sharrock, SP McManaway, MH Rich, JS Mumm, IF Hermans, M Tercel, ... Frontiers in Pharmacology 12, 701456, 2021 | 11 | 2021 |
| A cofactor consumption screen identifies promising NfsB family nitroreductases for dinitrotoluene remediation EM Williams, AV Sharrock, EL Rylott, NC Bruce, JK MacKichan, ... Biotechnology letters 41, 1155-1162, 2019 | 7 | 2019 |
| Preparation, analysis and toxicity characterisation of the redox metabolites of the azo food dye tartrazine R Pay, AV Sharrock, R Elder, A Maré, J Bracegirdle, D Torres, N Malone, ... Food and Chemical Toxicology 182, 114193, 2023 | 3 | 2023 |
| An inducible model of chronic hyperglycemia TR Tucker, CA Knitter, DM Khoury, S Eshghi, S Tran, AV Sharrock, ... Disease Models & Mechanisms 16 (8), 2023 | 3 | 2023 |
| The crystal structure of engineered nitroreductase NTR 2.0 and impact of F70A and F108Y substitutions on substrate specificity AV Sharrock, JS Mumm, G Bagdžiūnas, N Čėnas, VL Arcus, DF Ackerley International journal of molecular sciences 24 (7), 6633, 2023 | 3 | 2023 |
| The Catalysis Mechanism of E. coli Nitroreductase A, a Candidate for Gene-Directed Prodrug Therapy: Potentiometric and Substrate Specificity Studies B Valiauga, G Bagdžiūnas, AV Sharrock, DF Ackerley, N Čėnas International Journal of Molecular Sciences 25 (8), 4413, 2024 | 1 | 2024 |
| Development of a compartmentalised self-replication protocol for selection of superior blunt-end DNA ligases LJ Stevenson, KJ Robins, JK Sharma, EM Williams, AV Sharrock, ... Enzyme and Microbial Technology 163, 110153, 2023 | 1 | 2023 |
| Molecular regulation of retinal regeneration is context specific K Emmerich, J Hageter, T Hoang, P Lyu, AV Sharrock, A Ceisel, J Thierer, ... bioRxiv, 2023.11. 20.567904, 2023 | 1 | 2023 |
| Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug MH Rich, AV Sharrock, A Ashoorzadeh, AV Patterson, JB Smaill, ... Biotechnology Letters 43, 203-211, 2021 | 1 | 2021 |
| Engineering Nitroreductase Enzymes for Improved Cancer Gene Therapy and Targeted Cellular Ablation AV Sharrock Open Access Te Herenga Waka-Victoria University of Wellington, 2019 | 1 | 2019 |
