| Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis CP Najt, S Senthivinayagam, MB Aljazi, KA Fader, SD Olenic, JRL Brock, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 310 (9 …, 2016 | 125 | 2016 |
| 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism KA Fader, R Nault, C Zhang, K Kumagai, JR Harkema, TR Zacharewski Scientific reports 7 (1), 5921, 2017 | 72 | 2017 |
| Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis R Nault, KA Fader, DA Ammendolia, P Dornbos, D Potter, B Sharratt, ... Toxicological Sciences 154 (2), 253-266, 2016 | 70 | 2016 |
| Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin R Nault, KA Fader, TA Lydic, TR Zacharewski Chemical research in toxicology 30 (4), 1060-1075, 2017 | 58 | 2017 |
| 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice KA Fader, R Nault, DA Ammendolia, JR Harkema, KJ Williams, ... Toxicological Sciences 148 (2), 567-580, 2015 | 55 | 2015 |
| Single-nuclei RNA sequencing assessment of the hepatic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin R Nault, KA Fader, S Bhattacharya, TR Zacharewski Cellular and Molecular Gastroenterology and Hepatology 11 (1), 147-159, 2021 | 53 | 2021 |
| 2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice KA Fader, R Nault, CM Doskey, RR Fling, TR Zacharewski Scientific reports 9 (1), 6514, 2019 | 48 | 2019 |
| Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin R Nault, KA Fader, MP Kirby, S Ahmed, J Matthews, AD Jones, SY Lunt, ... Toxicological Sciences 149 (2), 358-371, 2016 | 47 | 2016 |
| Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity KA Fader, R Nault, MP Kirby, G Markous, J Matthews, TR Zacharewski Toxicology and applied pharmacology 321, 1-17, 2017 | 45 | 2017 |
| TCDD influences reservoir of antibiotic resistance genes in murine gut microbiome RD Stedtfeld, TM Stedtfeld, KA Fader, MR Williams, P Bhaduri, J Quensen, ... FEMS microbiology ecology 93 (5), fix058, 2017 | 41 | 2017 |
| RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice R Nault, KA Fader, T Zacharewski BMC genomics 16, 1-12, 2015 | 38 | 2015 |
| From the cover: coagulation-driven hepatic fibrosis requires protease activated receptor-1 (PAR-1) in a mouse model of TCDD-elicited steatohepatitis R Nault, KA Fader, AK Kopec, JR Harkema, TR Zacharewski, ... Toxicological Sciences 154 (2), 381-391, 2016 | 36 | 2016 |
| Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice R Nault, KA Fader, JR Harkema, T Zacharewski PloS one 12 (9), e0184842, 2017 | 35 | 2017 |
| Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species KA Fader, ID Pardo, RC Kovi, CJ Somps, HH Wang, VS Vaidya, ... Molecular Therapy-Methods & Clinical Development 25, 264-277, 2022 | 27 | 2022 |
| Comparison of hepatic NRF2 and aryl hydrocarbon receptor binding in 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin–treated mice demonstrates NRF2-independent PKM2 induction R Nault, CM Doskey, KA Fader, CE Rockwell, T Zacharewski Molecular Pharmacology 94 (2), 876-884, 2018 | 22 | 2018 |
| 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice RR Fling, CM Doskey, KA Fader, R Nault, TR Zacharewski Scientific Reports 10 (1), 14831, 2020 | 20 | 2020 |
| 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice KA Fader, R Nault, S Raehtz, LR McCabe, TR Zacharewski Toxicology and applied pharmacology 348, 85-98, 2018 | 18 | 2018 |
| 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats CM Doskey, KA Fader, R Nault, T Lydic, J Matthews, D Potter, B Sharratt, ... Toxicology and applied pharmacology 398, 115034, 2020 | 16 | 2020 |
| Beyond the aryl hydrocarbon receptor: pathway interactions in the hepatotoxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and related compounds KA Fader, TR Zacharewski Current opinion in toxicology 2, 36-41, 2017 | 16 | 2017 |
| Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation GN Cholico, RR Fling, NA Zacharewski, KA Fader, R Nault, ... Scientific reports 11 (1), 15689, 2021 | 15 | 2021 |
