Silicon incorporated morpholine antifungals: design, synthesis, and biological evaluation GR Jachak, R Ramesh, DG Sant, SU Jorwekar, MR Jadhav, SG Tupe, ... ACS Medicinal Chemistry Letters 6 (11), 1111-1116, 2015 | 50 | 2015 |
Specific stereoisomeric conformations determine the drug potency of cladosporin scaffold against malarial parasite P Das, P Babbar, N Malhotra, M Sharma, GR Jachak, RG Gonnade, ... Journal of Medicinal Chemistry 61 (13), 5664-5678, 2018 | 48 | 2018 |
Repurposing Ivacaftor for treatment of Staphylococcus aureus infections R Thakare, AK Singh, S Das, N Vasudevan, GR Jachak, DS Reddy, ... International journal of antimicrobial agents 50 (3), 389-392, 2017 | 39 | 2017 |
Total synthesis of the marine natural product solomonamide B necessitates stereochemical revision K Kashinath, GR Jachak, PR Athawale, UK Marelli, RG Gonnade, ... Organic letters 18 (13), 3178-3181, 2016 | 32 | 2016 |
Identification of new anti-inflammatory agents based on nitrosporeusine natural products of marine origin SC Philkhana, AK Verma, GR Jachak, B Hazra, A Basu, DS Reddy European Journal of Medicinal Chemistry 135, 89-109, 2017 | 19 | 2017 |
First synthesis of nitrosporeusines, alkaloids with multiple biological activities SC Philkhana, GR Jachak, VB Gunjal, NM Dhage, AH Bansode, ... Tetrahedron Letters 56 (10), 1252-1254, 2015 | 17 | 2015 |
Total synthesis of the potent anti-inflammatory natural product solomonamide A along with structural revision and biological activity evaluation GR Jachak, PR Athawale, H Agarwal, MK Barthwal, G Lauro, G Bifulco, ... Organic & Biomolecular Chemistry 16 (47), 9138-9142, 2018 | 12 | 2018 |
Breaking and Making of Rings: A Method for the Preparation of 4‐Quinolone‐3‐carboxylic Acid Amides and the Expensive Drug Ivacaftor N Vasudevan, GR Jachak, DS Reddy European Journal of Organic Chemistry 2015 (34), 7433-7437, 2015 | 12 | 2015 |
Efforts towards the synthesis of microsporin B: ready access to both the enantiomers of the key amino acid fragment PS Swaroop, S Tripathy, G Jachak, DS Reddy Tetrahedron Letters 55 (34), 4777-4779, 2014 | 8 | 2014 |
Identification of 5‑(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant GramPositive Bacteria CCA John R. Schultz, Stephen K. Costa, Gorakhnath R. Jachak, Pooja Hegde ... Journal of medicinal chemistry, 2022 | 7 | 2022 |
Access to a Stereoisomer Library of Solomonamide Macrocycles GR Jachak, PR Athawale, R Choudhury, K Kashinath, DS Reddy Chemistry–An Asian Journal 14 (24), 4572-4576, 2019 | 7 | 2019 |
Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation PR Athawale, GR Jachak, A Shukla, D Shanmugam, DS Reddy ACS omega 3 (2), 2383-2389, 2018 | 7 | 2018 |
Nitrosporeusine analogue ameliorates Chandipura virus induced inflammatory response in CNS via NFκb inactivation in microglia AK Verma, TS Waghmare, GR Jachak, SC Philkhana, DS Reddy, A Basu PLoS Neglected Tropical Diseases 12 (7), e0006648, 2018 | 6 | 2018 |
Stereocontrolled Synthesis of Pseurotin A2 GRJ Prabhakara R. Tharra, Petr Sevelda, Jakub Švenda The Journal of Organic Chemistry 86, 11845, 2021 | 5* | 2021 |
Scalable Synthesis of Both Enantiomers of Vigabatrin, an Antiepileptic Drug GR Jachak, DS Reddy European Journal of Organic Chemistry 2019 (6), 1257-1260, 2019 | 4 | 2019 |
Gram Scale Synthesis of Membrane-Active Antibacterial 4-Quinolone Lead Compound GR Jachak, MO Orimoloye, CC Aldrich The Journal of organic chemistry 88 (9), 6209-6217, 2023 | 3 | 2023 |
Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents CCA Pooja V. Hegde, Wassihun W. Aragaw, Malcolm S. Col, Gorakhnath Jachak ... Bioorganic & Medicinal Chemistry, 2022 | 3 | 2022 |
Comprehensive Study on Solomonamides: Total Synthesis, Stereochemical Revision, and SAR Studies toward Identification of Simplified Lead GR Jachak, K Kashinath, N Vasudevan, PR Athawale, R Choudhury, ... The Journal of Organic Chemistry 88 (24), 17088-17133, 2023 | 1 | 2023 |
Synthesis and Biological Evaluation of Hoshionolactam‐Based Compounds GR Jachak, D Elizebath, A Shukla, D Shanmugam, DS Reddy European Journal of Organic Chemistry 2021 (15), 2212-2218, 2021 | 1 | 2021 |
Process for the synthesis of ivacaftor and related compounds DS Reddy, V Natarajan, GR Jachak US Patent 10,336,703, 2019 | 1 | 2019 |