Highly efficient chemoenzymatic synthesis of β1–4-linked galactosides with promiscuous bacterial β1–4-galactosyltransferases K Lau, V Thon, H Yu, L Ding, Y Chen, MM Muthana, D Wong, R Huang, ... Chemical communications 46 (33), 6066-6068, 2010 | 194 | 2010 |
Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP) MM Muthana, J Qu, Y Li, L Zhang, H Yu, L Ding, H Malekan, X Chen Chemical communications 48 (21), 2728-2730, 2012 | 131 | 2012 |
Donor substrate promiscuity of bacterial β1–3-N-acetylglucosaminyltransferases and acceptor substrate flexibility of β1–4-galactosyltransferases Y Li, M Xue, X Sheng, H Yu, J Zeng, V Thon, Y Chen, MM Muthana, ... Bioorganic & medicinal chemistry 24 (8), 1696-1705, 2016 | 56 | 2016 |
Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid Z Khedri, MM Muthana, Y Li, SM Muthana, H Yu, H Cao, X Chen Chemical communications 48 (27), 3357-3359, 2012 | 51 | 2012 |
Improved one-pot multienzyme (OPME) systems for synthesizing UDP-uronic acids and glucuronides MM Muthana, J Qu, M Xue, T Klyuchnik, A Siu, Y Li, L Zhang, H Yu, L Li, ... Chemical Communications 51 (22), 4595-4598, 2015 | 48 | 2015 |
Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT) X Ma, P Liu, H Yan, H Sun, X Liu, F Zhou, L Li, Y Chen, MM Muthana, ... PloS one 8 (5), e63452, 2013 | 42 | 2013 |
Systematic chemoenzymatic synthesis of O-sulfated sialyl Lewis x antigens A Santra, H Yu, N Tasnima, MM Muthana, Y Li, J Zeng, NJ Kenyon, ... Chemical science 7 (4), 2827-2831, 2016 | 37 | 2016 |
Chemoenzymatic synthesis of sialosides containing C7-modified sialic acids and their application in sialidase substrate specificity studies Z Khedri, Y Li, S Muthana, MM Muthana, CW Hsiao, H Yu, X Chen Carbohydrate research 389, 100-111, 2014 | 36 | 2014 |
Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2 Z Khedri, Y Li, H Cao, J Qu, H Yu, MM Muthana, X Chen Organic & biomolecular chemistry 10 (30), 6112-6120, 2012 | 33 | 2012 |
Donor substrate promiscuity of the N-acetylglucosaminyltransferase activities of Pasteurella multocida heparosan synthase 2 (PmHS2) and Escherichia coli K5 KfiA Y Li, H Yu, V Thon, Y Chen, MM Muthana, J Qu, L Hie, X Chen Applied microbiology and biotechnology 98, 1127-1134, 2014 | 30 | 2014 |
Site-specific chemoenzymatic conjugation of high-affinity M6P glycan ligands to antibodies for targeted protein degradation X Zhang, H Liu, J He, C Ou, TC Donahue, MM Muthana, L Su, LX Wang ACS chemical biology 17 (11), 3013-3023, 2022 | 26 | 2022 |
9-Azido-9-deoxy-2, 3-difluorosialic acid as a subnanomolar inhibitor against bacterial sialidases W Li, A Santra, H Yu, TJ Slack, MM Muthana, D Shi, Y Liu, X Chen The Journal of organic chemistry 84 (11), 6697-6708, 2019 | 18 | 2019 |
Characterizing non-hydrolyzing Neisseria meningitidis serogroup A UDP-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase using UDP-N-acetylmannosamine (UDP-ManNAc) and derivatives L Zhang, MM Muthana, H Yu, JB McArthur, J Qu, X Chen Carbohydrate research 419, 18-28, 2016 | 14 | 2016 |
S-15 in combination of Akt inhibitor promotes the expansion of CD45RA−CCR7+ tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1+Tim-3 … B Xu, L Yuan, G Chen, T Li, J Zhou, C Zhang, P Qin, MM Muthana, ... Cancer Cell International 19, 1-11, 2019 | 5 | 2019 |
Soluble CTLA-4 mutants ameliorate immune-related adverse events but preserve efficacy of CTLA-4–and PD-1–targeted immunotherapy M Liu, X Wang, X Du, W Wu, Y Zhang, P Zhang, C Ai, M Devenport, J Su, ... Science translational medicine 15 (685), eabm5663, 2023 | 4 | 2023 |
Insight into the molecular basis of substrate recognition by the wall teichoic acid glycosyltransferase TagA OE Martinez, BJ Mahoney, AK Goring, SW Yi, DP Tran, D Cascio, ... Journal of Biological Chemistry 298 (2), 2022 | 4 | 2022 |
CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment MM Muthana, X Du, M Liu, X Wang, W Wu, C Ai, L Su, P Zheng, Y Liu Elife 12, RP87281, 2023 | 2 | 2023 |
Chemoenzymatic synthesis of heparin and heparan sulfate analogs X Chen, H Yu, Y Li, Y Chen, J Qu, MM Muthana, K Lau, L Bode US Patent 10,160,986, 2018 | 2 | 2018 |
Chemoenzymatic synthesis of heparin and heparan sulfate analogs X Chen, H Yu, K Lau, L Bode US Patent 9,290,530, 2016 | 2 | 2016 |
One-Pot Chemoenzymatic Synthesis of UDP-Sugars and Sulfated Glycans MM Muthana University of California, Davis, 2015 | | 2015 |