| Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity Z Qin, I Kastrati, REP Chandrasena, H Liu, P Yao, PA Petukhov, JL Bolton, ... Journal of Medicinal Chemistry 50 (11), 2682-2692, 2007 | 179 | 2007 |
| Dimethyl fumarate inhibits the nuclear factor κB pathway in breast cancer cells by covalent modification of p65 protein I Kastrati, MI Siklos, EL Calderon-Gierszal, L El-Shennawy, G Georgieva, ... Journal of Biological Chemistry 291 (7), 3639-3647, 2016 | 149 | 2016 |
| Structural and molecular mechanisms of cytokine-mediated endocrine resistance in human breast cancer cells JD Stender, JC Nwachukwu, I Kastrati, Y Kim, T Strid, M Yakir, ... Molecular cell 65 (6), 1122-1135. e5, 2017 | 115 | 2017 |
| PHLDA1 expression is controlled by an estrogen receptor-NFκB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres I Kastrati, E Canestrari, J Frasor Oncogene 34 (18), 2309-2316, 2015 | 71 | 2015 |
| Full antagonism of the estrogen receptor without a prototypical ligand side chain S Srinivasan, JC Nwachukwu, NE Bruno, V Dharmarajan, D Goswami, ... Nature chemical biology 13 (1), 111-118, 2017 | 63 | 2017 |
| NFκB affects estrogen receptor expression and activity in breast cancer through multiple mechanisms J Frasor, L El-Shennawy, JD Stender, I Kastrati Molecular and cellular endocrinology 418, 235-239, 2015 | 63 | 2015 |
| Structure–activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene CR Overk, KW Peng, RT Asghodom, I Kastrati, DD Lantvit, Z Qin, J Frasor, ... ChemMedChem: Chemistry Enabling Drug Discovery 2 (10), 1520-1526, 2007 | 61 | 2007 |
| The NF-κB pathway promotes tamoxifen tolerance and disease recurrence in estrogen receptor–positive breast cancers I Kastrati, SEP Joosten, SE Semina, LH Alejo, SD Brovkovych, JD Stender, ... Molecular Cancer Research 18 (7), 1018-1027, 2020 | 42 | 2020 |
| Coactivation of estrogen receptor and IKKβ induces a dormant metastatic phenotype in ER-positive breast cancer L El-Shennawy, O Dubrovskyi, I Kastrati, JM Danes, Y Zhang, ... Cancer research 78 (4), 974-984, 2018 | 39 | 2018 |
| Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms B Yu, BM Dietz, T Dunlap, I Kastrati, DD Lantvit, CR Overk, P Yao, Z Qin, ... Molecular cancer therapeutics 6 (9), 2418-2428, 2007 | 36 | 2007 |
| A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties I Kastrati, VA Litosh, S Zhao, M Alvarez, GRJ Thatcher, J Frasor BMC cancer 15, 1-12, 2015 | 28 | 2015 |
| Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators Z Qin, I Kastrati, RT Ashgodom, DD Lantvit, CR Overk, Y Choi, ... Drug metabolism and disposition 37 (1), 161-169, 2009 | 28 | 2009 |
| Estrogen-induced apoptosis of breast epithelial cells is blocked by NO/cGMP and mediated by extranuclear estrogen receptors I Kastrati, PD Edirisinghe, GT Wijewickrama, GRJ Thatcher Endocrinology 151 (12), 5602-5616, 2010 | 21 | 2010 |
| SELENOF is a new tumor suppressor in breast cancer A Zigrossi, LK Hong, RC Ekyalongo, C Cruz-Alvarez, E Gornick, ... Oncogene 41 (9), 1263-1268, 2022 | 18 | 2022 |
| Insights into how phosphorylation of estrogen receptor at serine 305 modulates tamoxifen activity in breast cancer I Kastrati, S Semina, B Gordon, E Smart Molecular and cellular endocrinology 483, 97-101, 2019 | 17 | 2019 |
| Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells M Chang, K Peng, I Kastrati, CR Overk, ZH Qin, P Yao, JL Bolton, ... Endocrinology 148 (10), 4793-4802, 2007 | 17 | 2007 |
| Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells I Kastrati, PD Edirisinghe, LPMP Hemachandra, ER Chandrasena, J Choi, ... PLoS One 6 (11), e27876, 2011 | 16 | 2011 |
| Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine‐based Histone Deacetylase Inhibitors H Abdelkarim, R Neelarapu, A Madriaga, AS Vaidya, I Kastrati, ... ChemMedChem 12 (24), 2030-2043, 2017 | 14 | 2017 |
| Selenium and breast cancer–An update of clinical and epidemiological data B Flowers, A Poles, I Kastrati Archives of Biochemistry and Biophysics 732, 109465, 2022 | 12 | 2022 |
| A novel strategy to co-target estrogen receptor and nuclear factor κB pathways with hybrid drugs for breast cancer therapy I Kastrati, MI Siklos, SD Brovkovych, GRJ Thatcher, J Frasor Hormones and Cancer 8 (3), 135-142, 2017 | 12 | 2017 |
