Therapeutically relevant engraftment of a CRISPR-Cas9–edited HSC-enriched population with HbF reactivation in nonhuman primates O Humbert, S Radtke, C Samuelson, RR Carrillo, AM Perez, SS Reddy, ... Science translational medicine 11 (503), eaaw3768, 2019 | 112 | 2019 |
Contact guidance diversity in rotationally aligned collagen matrices JAM Nuhn, AM Perez, IC Schneider Acta biomaterialia 66, 248-257, 2018 | 62 | 2018 |
Purification of human CD34+ CD90+ HSCs reduces target cell population and improves lentiviral transduction for gene therapy S Radtke, D Pande, M Cui, AM Perez, YY Chan, M Enstrom, S Schmuck, ... Molecular Therapy Methods & Clinical Development 18, 679-691, 2020 | 37 | 2020 |
Efficient polymer nanoparticle-mediated delivery of gene editing reagents into human hematopoietic stem and progenitor cells R El-Kharrag, KE Berckmueller, R Madhu, M Cui, G Campoy, HM Mack, ... Molecular Therapy 30 (6), 2186-2198, 2022 | 29 | 2022 |
Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering KR Michels, A Sheih, SA Hernandez, AH Brandes, D Parrilla, B Irwin, ... Journal for immunotherapy of cancer 11 (3), 2023 | 28 | 2023 |
Stochastic fate decisions of HSCs after transplantation: early contribution, symmetric expansion, and pool formation S Radtke, M Enstrom, D Pande, ER Duke, EF Cardozo-Ojeda, R Madhu, ... Blood, The Journal of the American Society of Hematology 142 (1), 33-43, 2023 | 8 | 2023 |
Preparation and gene modification of nonhuman primate hematopoietic stem and progenitor cells S Radtke, AM Perez, R Venkataraman, S Reddy, KG Haworth, O Humbert, ... JoVE (Journal of Visualized Experiments), e58933, 2019 | 7 | 2019 |
The rationale of using coffee and melatonin as an alternative treatment for alzheimer’s disease A Perez, T Li, S Hernandez, R Zhang, C Cao J Alzheimers Dis Parkinsonism 6 (205), 2161-0460.1000205, 2016 | 7 | 2016 |
Régimen de «visitas» del progenitor no custodio, su incidencia en la relación abuelosnietos A Pérez La protección del menor en las rupturas de pareja, 341-374, 2009 | 6 | 2009 |
Vivovec™ Surface-Engineered Lentiviral Particles Mediate In Vivo CAR T Generation with Potent and Highly Durable Activity in Non-Human Primates and Tumor-Bearing Humanized Mice M Parker, J Ulrich-Lewis, W Tang, C Nicolai, K Michels, S Hernandez, ... Blood 142, 765, 2023 | 4 | 2023 |
AMD3100 redosing fails to repeatedly mobilize hematopoietic stem cells in the nonhuman primate and humanized mouse C Samuelson, S Radtke, M Cui, A Perez, HP Kiem, O Humbert Experimental hematology 93, 52-60. e1, 2021 | 4 | 2021 |
Isolation of a highly purified HSC-enriched CD34+ CD90+ CD45RA− cell subset for allogeneic transplantation in the nonhuman primate large-animal model S Radtke, L Colonna, AM Perez, M Hoffman, LS Kean, HP Kiem Transplantation Direct 6 (8), e579, 2020 | 4 | 2020 |
Sort-purification of human CD34+CD90+ cells reduces target cell population and improves lentiviral transduction S Radtke, D Pande, M Cui, AM Perez, YY Chan, M Enstrom, S Schmuck, ... bioRxiv, 850479, 2019 | 4 | 2019 |
Efficient nanoparticle-mediated delivery of gene editing reagents into human hematopoietic stem and progenitor cells R El Kharrag, K Berckmueller, M Cui, R Madhu, AM Perez, O Humbert, ... Blood 138, 2933, 2021 | 2 | 2021 |
Hematopoietic recovery after transplantation is primarily derived from the stochastic contribution of hematopoietic stem cells S Radtke, M Enstrom, D Pande, M Cui, R Madhu, AM Perez, HP Kiem bioRxiv, 2021.09. 21.461235, 2021 | 1 | 2021 |
Transplantation and persistence of CRISPR/Cas9-edited hematopoietic stem and progenitors cells for the reactivation of fetal hemoglobin in nonhuman primates O Humbert, S Radtke, RR Carrillo, SS Reddy, AM Perez, C Lux, ... MOLECULAR THERAPY 26 (5), 296-296, 2018 | 1 | 2018 |
438 In vivo Engineered CAR-T cells for oncology using a surface-engineered lentivirus platform: nonclinical safety and biodistribution A Brandes, SM Koo, D Parilla, S Hernandez, C Nicolai, A Sheih, A Ting, ... Journal for ImmunoTherapy of Cancer 11 (Suppl 1), 2023 | | 2023 |
HSCs Engraft in a Stochastic Pattern and Form Clonal Pools after Transplantation S Radtke, M Enstrom, D Pande, R Madhu, S Owen, G Kanestrom, M Cui, ... Blood 140 (Supplement 1), 5719-5720, 2022 | | 2022 |
Preclinical Activity and Safety of UB-VV100, A Novel Lentiviral Vector Product Designed for Selective and Effective In Vivo Engineering of Therapeutic Anti-CD19 CART Cells for … AH Brandes, S Geisinger, A Sheih, A Ting, K Michels, SA Hernandez, ... MOLECULAR THERAPY 30 (4), 579-580, 2022 | | 2022 |
UB-VV100, a Novel Platform for In Vivo Engineering of Therapeutic Anti-CD19 CAR T Cells, Shows Effective T Cell Transduction, B Cell Depletion, and Tumor Control in a Humanized … KR Michels, AM Sullivan, CJ Nicolai, SH Lopez, L Beitz, J Whalen, ... MOLECULAR THERAPY 29 (4), 310-310, 2021 | | 2021 |