A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing L Rolinger, M Ruedt, J Hubbuch Analytical and bioanalytical chemistry 412, 2047-2064, 2020 | 105 | 2020 |
Real‐time monitoring and control of the load phase of a protein A capture step M Rüdt, N Brestrich, L Rolinger, J Hubbuch Biotechnology and bioengineering 114 (2), 368-373, 2017 | 69 | 2017 |
Multi-attribute PAT for UF/DF of Proteins—Monitoring Concentration, particle sizes, and Buffer Exchange L Rolinger, M Rüdt, J Diehm, J Chow-Hubbertz, M Heitmann, S Schleper, ... Analytical and bioanalytical chemistry 412, 2123-2136, 2020 | 42 | 2020 |
Comparison of UV‐and Raman‐based monitoring of the protein A load phase and evaluation of data fusion by PLS models and CNNs L Rolinger, M Rüdt, J Hubbuch Biotechnology and Bioengineering 118 (11), 4255-4268, 2021 | 23 | 2021 |
Monitoring of ultra-and diafiltration processes by Kalman-filtered Raman measurements L Rolinger, J Hubbuch, M Rüdt Analytical and Bioanalytical Chemistry 415 (5), 841-854, 2023 | 13 | 2023 |
A multisensor approach for improved protein A load phase monitoring by conductivity‐based background subtraction of UV spectra L Rolinger, M Rüdt, J Hubbuch Biotechnology and bioengineering 118 (2), 905-917, 2021 | 9 | 2021 |
Mini-batch continuous direct compression: Overview and control strategy insights M Bautista, R Maurer, L Rolinger, E Gavi, PM Piccione American Pharmaceutical Review, 1-8, 2022 | 5 | 2022 |
Method for controlling continuous chromatography and multi-column chromatography arrangement J Hubbuch, N Brestrich, M Rüdt, L Rolinger US Patent App. 15/777,898, 2018 | 3 | 2018 |
Development of a blending design space model to control blend uniformity in a mini-batch direct compression line M Bautista, L Rolinger, F Stump, A Ewert, M Saetzler, R Maurer, J Lamerz Powder Technology, 120675, 2025 | | 2025 |
Correction to: Monitoring of ultra-and diafiltration processes by Kalman-filtered Raman measurements L Rolinger, J Hubbuch, M Rüdt Analytical and Bioanalytical Chemistry 416 (7), 1775-1775, 2024 | | 2024 |
Smart PAT Concepts for the Downstream Process of Biologics--Application of Multimodal Soft Sensors, Machine Learning, and Data Fusion LM Rolinger KIT-Bibliothek, 2022 | | 2022 |
UF/DF monitoring and control by variable pathlength UV/Vis spectroscopy, light scattering and density measurements L Rolinger, M Ruedt, J Diehm, J Hubbuch ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 257, 2019 | | 2019 |
Monitoring and control of capture steps by spectroscopy combined with PLS modeling L Rolinger, M Rudt, N Brestrich, J Hubbuch ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255, 2018 | | 2018 |
Real-time monitoring of critical quality attributes and process parameters by spectroscopy during chromatographic capture and polishing steps M Rudt, N Bestrich, D Buchler, L Rolinger, A Sanden, J Hubbuch ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253, 2017 | | 2017 |
Smart PAT concepts for the downstream process of biologics LM Rolinger | | |