| HMDB 5.0: the human metabolome database for 2022 DS Wishart, AC Guo, E Oler, F Wang, A Anjum, H Peters, R Dizon, ... Nucleic acids research 50 (D1), D622-D631, 2022 | 1051 | 2022 |
| Mildronate: cardioprotective action through carnitine-lowering effect M Dambrova, E Liepinsh, I Kalvinsh Trends in cardiovascular medicine 12 (6), 275-279, 2002 | 256 | 2002 |
| Diabetes is associated with higher trimethylamine N-oxide plasma levels M Dambrova, G Latkovskis, J Kuka, I Strele, I Konrade, S Grinberga, ... Experimental and clinical endocrinology & diabetes 124 (04), 251-256, 2016 | 232 | 2016 |
| Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials M Dambrova, M Makrecka-Kuka, J Kuka, R Vilskersts, D Nordberg, ... Pharmacological Reviews 74 (3), 506-551, 2022 | 173 | 2022 |
| Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity M Dambrova, M Makrecka-Kuka, R Vilskersts, E Makarova, J Kuka, ... Pharmacological research 113, 771-780, 2016 | 153 | 2016 |
| Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues M Makrecka-Kuka, E Sevostjanovs, K Vilks, K Volska, U Antone, J Kuka, ... Scientific reports 7 (1), 17528, 2017 | 133 | 2017 |
| Acute anti‐hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study E Makarova, P Górnaś, I Konrade, D Tirzite, H Cirule, A Gulbe, I Pugajeva, ... Journal of the Science of Food and Agriculture 95 (3), 560-568, 2015 | 130 | 2015 |
| Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction E Liepinsh, R Vilskersts, D Loca, O Kirjanova, O Pugovichs, I Kalvinsh, ... Journal of cardiovascular pharmacology 48 (6), 314-319, 2006 | 130 | 2006 |
| Cardiac metabolism as a driver and therapeutic target of myocardial infarction CJ Zuurbier, L Bertrand, CR Beauloye, I Andreadou, M Ruiz‐Meana, ... Journal of cellular and molecular medicine 24 (11), 5937-5954, 2020 | 122 | 2020 |
| Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation J Kuka, E Liepinsh, M Makrecka-Kuka, J Liepins, H Cirule, D Gustina, ... Life sciences 117 (2), 84-92, 2014 | 118 | 2014 |
| Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria M Makrecka-Kuka, K Volska, U Antone, R Vilskersts, S Grinberga, ... Toxicology letters 267, 32-38, 2017 | 108 | 2017 |
| Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury M Dambrova, CJ Zuurbier, V Borutaite, E Liepinsh, M Makrecka-Kuka Free Radical Biology and Medicine 165, 24-37, 2021 | 105 | 2021 |
| Protective effects of mildronate in an experimental model of type 2 diabetes in Goto‐Kakizaki rats E Liepinsh, R Vilskersts, L Zvejniece, B Svalbe, E Skapare, J Kuka, ... British journal of pharmacology 157 (8), 1549-1556, 2009 | 105 | 2009 |
| Comparative pharmacological activity of optical isomers of phenibut M Dambrova, L Zvejniece, E Liepinsh, H Cirule, O Zharkova, G Veinberg, ... European journal of pharmacology 583 (1), 128-134, 2008 | 96 | 2008 |
| Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria E Liepinsh, M Makrecka-Kuka, K Volska, J Kuka, E Makarova, U Antone, ... Biochemical Journal 473 (9), 1191-1202, 2016 | 93 | 2016 |
| [3H] RS79948-197 binding to human, rat, guinea pig and pig α2A-, α2B-and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine S Uhlén, M Dambrova, J Näsman, HB Schiöth, Y Gu, A Wikberg-Matsson, ... European journal of pharmacology 343 (1), 93-101, 1998 | 92 | 1998 |
| Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart E Liepinsh, R Vilskersts, E Skapare, B Svalbe, J Kuka, H Cirule, ... Life sciences 83 (17-18), 613-619, 2008 | 91 | 2008 |
| Structure and function of CutC choline lyase from human microbiota bacterium Klebsiella pneumoniae G Kalnins, J Kuka, S Grinberga, M Makrecka-Kuka, E Liepinsh, ... Journal of Biological Chemistry 290 (35), 21732-21740, 2015 | 86 | 2015 |
| Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis. M Dambrova, E Skapare‐Makarova, I Konrade, O Pugovics, S Grinberga, ... Journal of Clinical Pharmacology 53 (10), 2013 | 83 | 2013 |
| Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism K Jaudzems, J Kuka, A Gutsaits, K Zinovjevs, I Kalvinsh, E Liepinsh, ... Journal of enzyme inhibition and medicinal chemistry 24 (6), 1269-1275, 2009 | 80 | 2009 |
