| TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques Y Wang, TK Ulland, JD Ulrich, W Song, JA Tzaferis, JT Hole, P Yuan, ... The Journal of experimental medicine 213 (5), 667, 2016 | 768 | 2016 |
| TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy P Yuan, C Condello, CD Keene, Y Wang, TD Bird, SM Paul, W Luo, ... Neuron 90 (4), 724-739, 2016 | 762 | 2016 |
| Regional blood flow in the normal and ischemic brain is controlled by arteriolar smooth muscle cell contractility and not by capillary pericytes RA Hill*, L Tong*, P Yuan*, S Murikinati, S Gupta, J Grutzendler Neuron 87 (1), 95-110, 2015 | 721 | 2015 |
| Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques C Condello*, P Yuan*, A Schain, J Grutzendler Nature communications 6, 6176, 2015 | 583 | 2015 |
| Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques S Gowrishankar, P Yuan, Y Wu, M Schrag, S Paradise, J Grutzendler, ... Proceedings of the National Academy of Sciences 112 (28), E3699-E3708, 2015 | 371 | 2015 |
| Increased nanoparticle delivery to brain tumors by autocatalytic priming for improved treatment and imaging L Han, DK Kong, M Zheng, S Murikinati, C Ma, P Yuan, L Li, D Tian, Q Cai, ... ACS nano 10 (4), 4209-4218, 2016 | 115 | 2016 |
| Microglia-mediated neuroprotection, TREM2 and Alzheimer’s disease: Evidence from Optical Imaging C Condello*, P Yuan*, J Grutzendler Biological Psychiatry, 2017 | 109 | 2017 |
| A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease X Zhang, Y Tian, P Yuan, Y Li, MA Yaseen, J Grutzendler, A Moore, ... Chemical communications 50 (78), 11550-11553, 2014 | 106 | 2014 |
| Attenuation of β-amyloid deposition and neurotoxicity by chemogenetic modulation of neural activity P Yuan, J Grutzendler Journal of Neuroscience 36 (2), 632-641, 2016 | 105 | 2016 |
| Oxalate-curcumin–based probe for micro-and macroimaging of reactive oxygen species in Alzheimer’s disease J Yang*, X Zhang*, P Yuan*, J Yang, Y Xu, J Grutzendler, Y Shao, ... Proceedings of the National Academy of Sciences 114 (47), 12384-12389, 2017 | 102 | 2017 |
| Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation J Grutzendler, S Murikinati, B Hiner, L Ji, CK Lam, T Yoo, S Gupta, ... Science translational medicine 6 (226), 226ra31-226ra31, 2014 | 86 | 2014 |
| PLD3 affects axonal spheroids and network defects in Alzheimer’s disease P Yuan, M Zhang, L Tong, TM Morse, RA McDougal, H Ding, D Chan, ... Nature 612 (7939), 328-337, 2022 | 60 | 2022 |
| 3D super-resolution deep-tissue imaging in living mice MGM Velasco, M Zhang, J Antonello, P Yuan, ES Allgeyer, D May, ... Optica 8 (4), 442-450, 2021 | 59 | 2021 |
| Bacterial melanin interacts with double-stranded DNA with high affinity and may inhibit cell metabolism in vivo J Geng*, P Yuan*, C Shao, SB Yu, B Zhou, P Zhou, XD Chen Archives of microbiology 192 (5), 321-329, 2010 | 45 | 2010 |
| RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations S Yao*, P Yuan*, B Ouellette, T Zhou, M Mortrud, P Balaram, S Chatterjee, ... Nature Methods 17, 422–429, 2020 | 44 | 2020 |
| Imaging and optogenetic modulation of vascular mural cells in the live brain L Tong, RA Hill, EC Damisah, KN Murray, P Yuan, A Bordey, ... Nature protocols 16 (1), 472-496, 2021 | 40 | 2021 |
| Luteolin reduces BACE1 expression through NF-κB and estrogen receptor mediated pathways in HEK293 and SH-SY5Y cells N Zheng, P Yuan, C Li, J Wu, J Huang Journal of Alzheimer's Disease 45 (2), 659-671, 2015 | 39 | 2015 |
| Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome AM Maxwell, P Yuan, BM Rivera, W Schaaf, M Mladinov, VP Prasher, ... Acta Neuropathologica Communications 9, 1-15, 2021 | 20 | 2021 |
| CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model NR Johnson, P Yuan, E Castillo, TP Lopez, W Yue, A Bond, BM Rivera, ... Nature Communications 14 (1), 118, 2023 | 19 | 2023 |
| Absolute two-photon excitation spectra of red and far-red fluorescent probes MGM Velasco, ES Allgeyer, P Yuan, J Grutzendler, J Bewersdorf Optics letters 40 (21), 4915-4918, 2015 | 15 | 2015 |
Jaime GrutzendlerProfessor of Neurology and Neuroscience, Yale University在 yale.edu 的电子邮件经过验证
