| Evidence that G-quadruplex DNA accumulates in the cytoplasm and participates in stress granule assembly in response to oxidative stress AK Byrd, BL Zybailov, L Maddukuri, J Gao, JC Marecki, M Jaiswal, ... Journal of Biological Chemistry 291 (34), 18041-18057, 2016 | 87 | 2016 |
| Human Rev1 polymerase disrupts G-quadruplex DNA S Eddy, A Ketkar, MK Zafar, L Maddukuri, JY Choi, RL Eoff Nucleic acids research 42 (5), 3272-3285, 2014 | 77 | 2014 |
| Synthesis and anti-cancer screening of novel heterocyclic-(2 H)-1, 2, 3-triazoles as potential anti-cancer agents NR Penthala, L Madhukuri, S Thakkar, NR Madadi, G Lamture, RL Eoff, ... MedChemComm 6 (8), 1535-1543, 2015 | 57 | 2015 |
| Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA S Eddy, L Maddukuri, A Ketkar, MK Zafar, EE Henninger, ZF Pursell, ... Biochemistry 54 (20), 3218-3230, 2015 | 48 | 2015 |
| Human translesion polymerase κ exhibits enhanced activity and reduced fidelity two nucleotides from G-quadruplex DNA S Eddy, M Tillman, L Maddukuri, A Ketkar, MK Zafar, RL Eoff Biochemistry 55 (37), 5218-5229, 2016 | 42 | 2016 |
| In Vitro Bypass of the Major Malondialdehyde- and Base Propenal-Derived DNA Adduct by Human Y-family DNA Polymerases κ, ι, and Rev1 L Maddukuri, RL Eoff, JY Choi, CJ Rizzo, FP Guengerich, LJ Marnett Biochemistry 49 (38), 8415-8424, 2010 | 40 | 2010 |
| A small-molecule inhibitor of human DNA polymerase η potentiates the effects of cisplatin in tumor cells MK Zafar, L Maddukuri, A Ketkar, NR Penthala, MR Reed, S Eddy, ... Biochemistry 57 (7), 1262-1273, 2018 | 38 | 2018 |
| Kynurenine signaling increases DNA polymerase kappa expression and promotes genomic instability in glioblastoma cells ACL Bostian, L Maddukuri, MR Reed, T Savenka, JH Hartman, L Davis, ... Chemical research in toxicology 29 (1), 101-108, 2016 | 35 | 2016 |
| Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality M Pereira, P Mason, RJ Szczesny, L Maddukuri, S Dziwura, ... Mechanisms of ageing and development 128 (11-12), 609-617, 2007 | 35 | 2007 |
| Bacterial DNA repair genes and their eukaryotic homologues: 4. The role of nucleotide excision DNA repair (NER) system in mammalian cells. L Maddukuri, D Dudzińska, B Tudek Acta Biochimica Polonica 54 (3), 469-482, 2007 | 35 | 2007 |
| N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases GE Coggins, L Maddukuri, NR Penthala, JH Hartman, S Eddy, A Ketkar, ... ACS chemical biology 8 (8), 1722-1729, 2013 | 34 | 2013 |
| Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal L Maddukuri, E Speina, M Christiansen, D Dudzińska, J Zaim, ... Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 666 (1 …, 2009 | 32 | 2009 |
| Inhibition of human DNA polymerases eta and kappa by indole-derived molecules occurs through distinct mechanisms A Ketkar, L Maddukuri, NR Penthala, MR Reed, MK Zafar, PA Crooks, ... ACS chemical biology 14 (6), 1337-1351, 2019 | 25 | 2019 |
| Translesion synthesis across 1, N6-(2-hydroxy-3-hydroxymethylpropan-1, 3-diyl)-2′-deoxyadenosine (1, N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases S Kotapati, L Maddukuri, S Wickramaratne, U Seneviratne, M Goggin, ... Journal of Biological Chemistry 287 (46), 38800-38811, 2012 | 24 | 2012 |
| Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity A Ketkar, MK Zafar, L Maddukuri, K Yamanaka, S Banerjee, M Egli, ... Chemical research in toxicology 26 (2), 221-232, 2013 | 20 | 2013 |
| Selective Modulation of DNA Polymerase Activity by Fixed‐Conformation Nucleoside Analogues RL Eoff, CE McGrath, L Maddukuri, SG Salamanca‐Pinzón, VE Marquez, ... Angewandte Chemie International Edition 49 (41), 7481-7485, 2010 | 19 | 2010 |
| Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein L Maddukuri, A Ketkar, S Eddy, MK Zafar, WC Griffin, RL Eoff Journal of Biological Chemistry 287 (50), 42312-42323, 2012 | 18 | 2012 |
| A functional precision medicine pipeline combines comparative transcriptomics and tumor organoid modeling to identify bespoke treatment strategies for glioblastoma MR Reed, AG Lyle, A De Loose, L Maddukuri, K Learned, HC Beale, ... Cells 10 (12), 3400, 2021 | 16 | 2021 |
| Inhibition of tryptophan 2, 3-dioxygenase impairs DNA damage tolerance and repair in glioma cells MR Reed, L Maddukuri, A Ketkar, SD Byrum, MK Zafar, ACL Bostian, ... NAR cancer 3 (2), zcab014, 2021 | 16 | 2021 |
| The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa L Maddukuri, A Ketkar, S Eddy, MK Zafar, RL Eoff Nucleic acids research 42 (19), 12027-12040, 2014 | 16 | 2014 |
