Nuclear receptor Nur77 limits the macrophage inflammatory response through transcriptional reprogramming of mitochondrial metabolism DS Koenis, L Medzikovic, PB van Loenen, M van Weeghel, S Huveneers, ... Cell reports 24 (8), 2127-2140. e7, 2018 | 123 | 2018 |
Pulmonary hypertension secondary to pulmonary fibrosis: clinical data, histopathology and molecular insights G Ruffenach, J Hong, M Vaillancourt, L Medzikovic, M Eghbali Respiratory research 21, 1-14, 2020 | 57 | 2020 |
Single-cell study of two rat models of pulmonary arterial hypertension reveals connections to human pathobiology and drug repositioning J Hong, D Arneson, S Umar, G Ruffenach, CM Cunningham, IS Ahn, ... American journal of respiratory and critical care medicine 203 (8), 1006-1022, 2021 | 49 | 2021 |
Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines CM Cunningham, M Li, G Ruffenach, M Doshi, L Aryan, J Hong, J Park, ... American journal of respiratory and critical care medicine 206 (2), 186-196, 2022 | 47 | 2022 |
Connecting sex differences, estrogen signaling, and microRNAs in cardiac fibrosis L Medzikovic, L Aryan, M Eghbali Journal of Molecular Medicine 97, 1385-1398, 2019 | 46 | 2019 |
The role of microRNAs in acute respiratory distress syndrome and sepsis, from targets to therapies: a narrative review LK Lee, L Medzikovic, M Eghbali, HK Eltzschig, X Yuan Anesthesia & Analgesia 131 (5), 1471-1484, 2020 | 41 | 2020 |
Sex differences underlying preexisting cardiovascular disease and cardiovascular injury in COVID-19 L Medzikovic, CM Cunningham, M Li, M Amjedi, J Hong, G Ruffenach, ... Journal of Molecular and Cellular Cardiology 148, 25-33, 2020 | 37 | 2020 |
Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling L Medzikovic, CA Schumacher, AO Verkerk, ED van Deel, R Wolswinkel, ... Scientific reports 5 (1), 15404, 2015 | 37 | 2015 |
NR4A nuclear receptors in cardiac remodeling and neurohormonal regulation L Medzikovic, CJM de Vries, V de Waard Trends in cardiovascular medicine 29 (8), 429-437, 2019 | 36 | 2019 |
Role of miRNA-1 and miRNA-21 in acute myocardial ischemia-reperfusion injury and their potential as therapeutic strategy E Jayawardena, L Medzikovic, G Ruffenach, M Eghbali International journal of molecular sciences 23 (3), 1512, 2022 | 29 | 2022 |
Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension T Palao, L Medzikovic, C Rippe, S Wanga, C Al-Mardini, A van Weert, ... Cardiovascular Pathology 35, 12-19, 2018 | 27 | 2018 |
Nur77 protects against adverse cardiac remodelling by limiting neuropeptide Y signalling in the sympathoadrenal-cardiac axis L Medzikovic, C van Roomen, A Baartscheer, PB van Loenen, J de Vos, ... Cardiovascular research 114 (12), 1617-1628, 2018 | 23 | 2018 |
Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs L Aryan, L Medzikovic, S Umar, M Eghbali Biology of sex Differences 11, 1-17, 2020 | 20 | 2020 |
Nuclear receptor Nur77 controls cardiac fibrosis through distinct actions on fibroblasts and cardiomyocytes L Medzikovic, H Heese, PB van Loenen, CPAA van Roomen, ... International journal of molecular sciences 22 (4), 1600, 2021 | 17 | 2021 |
HNRNPA2B1: RNA-binding protein that orchestrates smooth muscle cell phenotype in pulmonary arterial hypertension G Ruffenach, L Medzikovic, L Aryan, M Li, M Eghbali Circulation 146 (16), 1243-1258, 2022 | 14 | 2022 |
Overexpression of nitric oxide synthase restores circulating angiogenic cell function in patients with coronary artery disease: implications for autologous cell therapy for … Q Chen, M Varga, X Wang, DJ Haddad, S An, L Medzikovic, ... Journal of the American Heart Association 5 (1), e002257, 2016 | 14 | 2016 |
Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans DS Koenis, L Medzikovic, M Vos, TJ Beldman, PB van Loenen, ... Journal of Biological Chemistry 293 (39), 15070-15083, 2018 | 13 | 2018 |
Myocardial fibrosis and calcification are attenuated by microRNA–129-5p targeting Asporin and Sox9 in cardiac fibroblasts L Medzikovic, L Aryan, G Ruffenach, M Li, N Savalli, W Sun, S Sarji, ... JCI insight 8 (9), 2023 | 6 | 2023 |
Experimental pulmonary hypertension is associated with neuroinflammation in the spinal cord M Vaillancourt, P Chia, L Medzikovic, N Cao, G Ruffenach, D Younessi, ... Frontiers in Physiology 10, 1186, 2019 | 6 | 2019 |
Sex differences in therapies against myocardial ischemia-reperfusion injury: from basic science to clinical perspectives L Medzikovic, T Azem, W Sun, P Rejali, L Esdin, S Rahman, ... Cells 12 (16), 2077, 2023 | 5 | 2023 |