| Fructose and sugar: A major mediator of non-alcoholic fatty liver disease T Jensen, MF Abdelmalek, S Sullivan, KJ Nadeau, M Green, C Roncal, ... Journal of hepatology 68 (5), 1063-1075, 2018 | 914 | 2018 |
| Phosphoinositide 3-kinase regulates glycolysis through mobilization of aldolase from the actin cytoskeleton H Hu, A Juvekar, CA Lyssiotis, EC Lien, JG Albeck, D Oh, G Varma, ... Cell 164 (3), 433-446, 2016 | 360 | 2016 |
| Intraneuronal Aβ42 accumulation in Down syndrome brain C Mori, ET Spooner, KE Wisniewski, TM Wisniewski, H Yamaguchi, ... Amyloid 9 (2), 88-102, 2002 | 350 | 2002 |
| Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease. MB Podlisny, DR Tolan, DJ Selkoe The American journal of pathology 138 (6), 1423, 1991 | 272 | 1991 |
| Uric acid as a cause of the metabolic syndrome C King, MA Lanaspa, T Jensen, DR Tolan, LG Sánchez-Lozada, ... Uric Acid in Chronic Kidney Disease 192, 88-102, 2018 | 174 | 2018 |
| The Molecular Nature of the F-actin Binding Activity of Aldolase Revealed with Site-directed Mutants (∗) J Wang, AJ Morris, DR Tolan, L Pagliaro Journal of Biological Chemistry 271 (12), 6861-6865, 1996 | 151 | 1996 |
| Climate change and the kidney RJ Johnson, LG Sánchez-Lozada, LS Newman, MA Lanaspa, HF Diaz, ... Annals of Nutrition and Metabolism 74 (Suppl. 3), 38-44, 2019 | 148 | 2019 |
| The complete nucleotide sequence for rabbit muscle aldolase A messenger RNA. DR Tolan, AB Amsden, SD Putney, MS Urdea, EE Penhoet Journal of Biological Chemistry 259 (2), 1127-1131, 1984 | 143 | 1984 |
| Molecular analysis of aldolase B genes in hereditary fructose intolerance NCP Cross, TM Cox, R De Franchis, G Sebastio, C Dazzo, DR Tolan, ... The Lancet 335 (8685), 306-309, 1990 | 122 | 1990 |
| Complete amino acid sequence for human aldolase B derived from cDNA and genomic clones. WH Rottmann, DR Tolan, EE Penhoet Proceedings of the National Academy of Sciences 81 (9), 2738-2742, 1984 | 115 | 1984 |
| Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice MA Lanaspa, A Andres-Hernando, DJ Orlicky, C Cicerchi, C Jang, N Li, ... The Journal of clinical investigation 128 (6), 2226-2238, 2018 | 107 | 2018 |
| The complete amino acid sequence for the anaerobically induced aldolase from maize derived from cDNA clones PM Kelley, DR Tolan Plant physiology 82 (4), 1076-1080, 1986 | 106 | 1986 |
| Site-directed mutagenesis identifies aspartate 33 as a previously unidentified critical residue in the catalytic mechanism of rabbit aldolase A. AJ Morris, DR Tolan Journal of Biological Chemistry 268 (2), 1095-1100, 1993 | 105 | 1993 |
| Catalytic deficiency of human aldolase B in hereditary fructose intolerance caused by a common missense mutation NCP Cross, DR Tolan, TM Cox Cell 53 (6), 881-885, 1988 | 104 | 1988 |
| Fructose contributes to the Warburg effect for cancer growth T Nakagawa, MA Lanaspa, IS Millan, M Fini, CJ Rivard, ... Cancer & Metabolism 8 (1), 1-12, 2020 | 103 | 2020 |
| Lysine-146 of rabbit muscle aldolase is essential for cleavage and condensation of the C3-C4 bond of fructose 1, 6-bis (phosphate) AJ Morris, DR Tolan Biochemistry 33 (40), 12291-12297, 1994 | 103 | 1994 |
| Snapshots of Catalysis: the Structure of Fructose-1,6-(bis)phosphate Aldolase Covalently Bound to the Substrate Dihydroxyacetone Phosphate, KH Choi, J Shi, CE Hopkins, DR Tolan, KN Allen Biochemistry 40 (46), 13868-13875, 2001 | 101 | 2001 |
| Targeting of several glycolytic enzymes using RNA interference reveals aldolase affects cancer cell proliferation through a non-glycolytic mechanism CR Lew, DR Tolan Journal of Biological Chemistry 287 (51), 42554-42563, 2012 | 100 | 2012 |
| Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts RJ Johnson, P Stenvinkel, P Andrews, LG Sánchez‐Lozada, T Nakagawa, ... Journal of Internal Medicine 287 (3), 252-262, 2020 | 92 | 2020 |
| Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity. MB Podlisny, DT Stephenson, MP Frosch, DR Tolan, I Lieberburg, ... The American journal of pathology 142 (1), 17, 1993 | 92 | 1993 |
Karen N. AllenChair and Professor, Department of Chemistry, Boston University在 bu.edu 的电子邮件经过验证
Karen N. AllenChair and Professor, Department of Chemistry, Boston University在 bu.edu 的电子邮件经过验证
Vincent FunariChief Scientific Officer, Imagia Canexia Health