| Structural stability of binding sites: consequences for binding affinity and allosteric effects I Luque, E Freire Proteins: Structure, Function, and Bioinformatics 41 (S4), 63-71, 2000 | 243 | 2000 |
| The linkage between protein folding and functional cooperativity: two sides of the same coin? I Luque, SA Leavitt, E Freire Annual review of biophysics and biomolecular structure 31 (1), 235-256, 2002 | 210 | 2002 |
| [6] Structure-based prediction of binding affinities and molecular design of peptide ligands I Luque, E Freire Methods in enzymology 295, 100-127, 1998 | 165 | 1998 |
| Thermodynamic basis of resistance to HIV-1 protease inhibition: calorimetric analysis of the V82F/I84V active site resistant mutant MJ Todd, I Luque, A Velázquez-Campoy, E Freire Biochemistry 39 (39), 11876-11883, 2000 | 156 | 2000 |
| Structural parameterization of the binding enthalpy of small ligands I Luque, E Freire Proteins: Structure, Function, and Bioinformatics 49 (2), 181-190, 2002 | 144 | 2002 |
| Structure-based thermodynamic scale of α-helix propensities in amino acids I Luque, OL Mayorga, E Freire Biochemistry 35 (42), 13681-13688, 1996 | 139 | 1996 |
| Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target A Nezami, I Luque, T Kimura, Y Kiso, E Freire Biochemistry 41 (7), 2273-2280, 2002 | 127 | 2002 |
| Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor A Velazquez-Campoy, I Luque, MJ Todd, M Milutinovich, Y Kiso, E Freire Protein Science 9 (9), 1801-1809, 2000 | 119 | 2000 |
| The strawberry pathogenesis-related 10 (PR-10) Fra a proteins control flavonoid biosynthesis by binding to metabolic intermediates A Casañal, U Zander, C Muñoz, F Dupeux, I Luque, MA Botella, ... Journal of Biological Chemistry 288 (49), 35322-35332, 2013 | 107 | 2013 |
| Molecular basis of resistance to HIV-1 protease inhibition: a plausible hypothesis I Luque, MJ Todd, J Gómez, N Semo, E Freire Biochemistry 37 (17), 5791-5797, 1998 | 100 | 1998 |
| Structure-based thermodynamic analysis of HIV-1 protease inhibitors JS Bardi, I Luque, E Freire Biochemistry 36 (22), 6588-6596, 1997 | 96 | 1997 |
| Molecular basis of histone H3K4me3 recognition by ING4 A Palacios, IG Muñoz, D Pantoja-Uceda, MJ Marcaida, D Torres, ... Journal of Biological Chemistry 283 (23), 15956-15964, 2008 | 95 | 2008 |
| Structure of p15PAF–PCNA complex and implications for clamp sliding during DNA replication and repair A De Biasio, AI De Opakua, GB Mortuza, R Molina, TN Cordeiro, ... Nature communications 6 (1), 6439, 2015 | 84 | 2015 |
| Thermodynamic dissection of the binding energetics of proline-rich peptides to the Abl-SH3 domain: implications for rational ligand design A Palencia, ES Cobos, PL Mateo, JC Martı́nez, I Luque Journal of molecular biology 336 (2), 527-537, 2004 | 78 | 2004 |
| WW domains of the yes-kinase-associated-protein (YAP) transcriptional regulator behave as independent units with different binding preferences for PPxY motif-containing ligands M Iglesias-Bexiga, F Castillo, ES Cobos, T Oka, M Sudol, I Luque PloS one 10 (1), e0113828, 2015 | 62 | 2015 |
| The application of thermodynamic methods in drug design A Velazquez-Campoy, I Luque, E Freire Thermochimica acta 380 (2), 217-227, 2001 | 61 | 2001 |
| Balancing the effect of corona on therapeutic efficacy and macrophage uptake of lipid nanocapsules P Sanchez-Moreno, P Buzon, H Boulaiz, JM Peula-García, ... Biomaterials 61, 266-278, 2015 | 59 | 2015 |
| New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells B Alburquerque-González, M Bernabé-García, S Montoro-García, ... Experimental & Molecular Medicine 52 (2), 281-292, 2020 | 52 | 2020 |
| Method for the prediction of binding targets and the design of ligands E Freire, I Luque US Patent 6,226,603, 2001 | 48 | 2001 |
| Structure‐based thermodynamic design of peptide ligands: Application to peptide inhibitors of the aspartic protease endothiapepsin I Luque, J Gómez, N Semo, E Freire Proteins: Structure, Function, and Bioinformatics 30 (1), 74-85, 1998 | 42 | 1998 |
Ernesto FreireHenry Walters Professor, Johns Hopkins University在 jhu.edu 的电子邮件经过验证
