Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome JL Bridgford, SC Xie, SA Cobbold, CFA Pasaje, S Herrmann, T Yang, ... Nature communications 9 (1), 3801, 2018 | 265 | 2018 |
Decreased K13 abundance reduces hemoglobin catabolism and proteotoxic stress, underpinning artemisinin resistance T Yang, LM Yeoh, MV Tutor, MW Dixon, PJ McMillan, SC Xie, JL Bridgford, ... Cell reports 29 (9), 2917-2928. e5, 2019 | 137 | 2019 |
Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins SC Xie, C Dogovski, E Hanssen, F Chiu, T Yang, MP Crespo, C Stafford, ... Journal of Cell Science 129 (2), 406-416, 2016 | 130 | 2016 |
MalDA, accelerating malaria drug discovery T Yang, S Ottilie, ES Istvan, KP Godinez-Macias, AK Lukens, B Baragaña, ... Trends in parasitology 37 (6), 493-507, 2021 | 63 | 2021 |
Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum … T Yang, SC Xie, P Cao, C Giannangelo, J McCaw, DJ Creek, ... Antimicrobial agents and chemotherapy 60 (8), 4501-4510, 2016 | 62 | 2016 |
Toxoplasma gondii rhomboid protein 1 (TgROM1) is a potential vaccine candidate against toxoplasmosis J Li, Q Han, P Gong, T Yang, B Ren, S Li, X Zhang Veterinary parasitology 184 (2-4), 154-160, 2012 | 40 | 2012 |
The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis SC Xie, RD Metcalfe, E Hanssen, T Yang, DL Gillett, AP Leis, CJ Morton, ... Nature microbiology 4 (11), 1990-2000, 2019 | 36 | 2019 |
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome. Nat Commun 9: 3801 JL Bridgford, SC Xie, SA Cobbold, CFA Pasaje, S Herrmann, T Yang, ... | 29 | 2018 |
Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity C Giannangelo, L Stingelin, T Yang, L Tilley, SA Charman, DJ Creek Antimicrobial Agents and Chemotherapy 62 (3), 10.1128/aac. 01566-17, 2018 | 17 | 2018 |
Dimeric artesunate glycerophosphocholine conjugate nano-assemblies as slow-release antimalarials to overcome Kelch 13 mutant artemisinin resistance Y Du, C Giannangelo, W He, GJ Shami, W Zhou, T Yang, DJ Creek, ... Antimicrobial Agents and Chemotherapy 66 (5), e02065-21, 2022 | 12 | 2022 |
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target ES Istvan, F Guerra, M Abraham, KS Huang, F Rocamora, H Zhao, L Xu, ... Science translational medicine 15 (686), eadc9249, 2023 | 10 | 2023 |
Decreased K13 abundance reduces hemoglobin catabolism and proteotoxic stress, underpinning artemisinin resistance. Cell Rep. 2019; 29: 2917–28 e5 T Yang, LM Yeoh, MV Tutor, MW Dixon, PJ McMillan, SC Xie Curr Opin Microbiol 16, 722-7, 2013 | 10 | 2013 |
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38 JF Armstrong, B Campo, SPH Alexander, LB Arendse, X Cheng, ... British Journal of Pharmacology 180 (15), 1899-1929, 2023 | 5 | 2023 |
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome. Nat Commun. 2018; 9: 3801 JL Bridgford, SC Xie, SA Cobbold, CFA Pasaje, S Herrmann, T Yang | 4 | |
The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol. 2019; 4: 1990–2000 SC Xie, RD Metcalfe, E Hanssen, T Yang, DL Gillett, AP Leis | 2 | |
CRYO-EM OF THE MALARIA PARASITE PA28/20S PROTEASOME COMPLEX REVEALS AN UNUSUAL ACTIVATION MECHANISM WITH IMPLICATIONS FOR ARTEMISININ SENSITIVITY S Xie, M Griffin, R Metcalfe, E Hanssen, T Yang, D Gilley, A Leis, C Morton, ... PROTEIN SCIENCE 28, 55-56, 2019 | | 2019 |