CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans AR Boobis, AM Lynch, S Murray, R de la Torre, A Solans, M Farré, ... Cancer research 54 (1), 89-94, 1994 | 319 | 1994 |
Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and … C Sachse, U Bhambra, G Smith, TJ Lightfoot, JH Barrett, J Scollay, ... British journal of clinical pharmacology 55 (1), 68-76, 2003 | 257 | 2003 |
Metabolic surgery and cancer: protective effects of bariatric procedures H Ashrafian, K Ahmed, SP Rowland, VM Patel, NJ Gooderham, E Holmes, ... Cancer 117 (9), 1788-1799, 2011 | 174 | 2011 |
Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer C Maihöfner, MP Charalambous, U Bhambra, T Lightfoot, G Geisslinger, ... Carcinogenesis 24 (4), 665-671, 2003 | 172* | 2003 |
Early events in the mammalian response to DNA double-strand breaks LC Riches, AM Lynch, NJ Gooderham Mutagenesis 23 (5), 331-339, 2008 | 143 | 2008 |
Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) in humans DG Walters, PJ Young, C Agus, MG Knize, AR Boobis, NJ Gooderham, ... Carcinogenesis 25 (9), 1659-1669, 2004 | 140 | 2004 |
Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man S Murray, BG Lake, S Gray, AJ Edwards, C Springall, EA Bowey, ... Carcinogenesis 22 (9), 1413-1420, 2001 | 133 | 2001 |
Intra-and interindividual variability in systemic exposure in humans to 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine … AM Lynch, MG Knize, AR Boobis, NJ Gooderham, DS Davies, S Murray Cancer Research 52 (22), 6216-6223, 1992 | 132 | 1992 |
Quantification of the carcinogens 2-amino-3, 8-dimethyl-and 2-amino-3, 4, 8-trimethylimidazo [4, 5-f] quinoxaline and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine in food … S Murray, AM Lynch, MG Knize, NJ Gooderham Journal of Chromatography B: Biomedical Sciences and Applications 616 (2 …, 1993 | 131 | 1993 |
Investigation of interaction between N -acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer JH Barrett, G Smith, R Waxman, N Gooderham, T Lightfoot, RC Garner, ... Carcinogenesis 24 (2), 275-282, 2003 | 122 | 2003 |
Identification of human urinary biomarkers of cruciferous vegetable consumption by metabonomic profiling WMB Edmands, OP Beckonert, C Stella, A Campbell, BG Lake, JC Lindon, ... Journal of proteome research 10 (10), 4513-4521, 2011 | 121 | 2011 |
Detection and measurement of MeIQx in human urine after ingestion of a cooked meat meal S Murray, NJ Gooderham, AR Boobis, DS Davies Carcinogenesis 10 (4), 763-765, 1989 | 119 | 1989 |
Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles MBH Abdul Rahim, J Chilloux, L Martinez-Gili, AL Neves, A Myridakis, ... Acta diabetologica 56, 493-500, 2019 | 117 | 2019 |
Nucleosomes bind to cell surface proteoglycans K Watson, NJ Gooderham, DS Davies, RJ Edwards Journal of Biological Chemistry 274 (31), 21707-21713, 1999 | 115 | 1999 |
Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I … D Kirkland, E Zeiger, F Madia, N Gooderham, P Kasper, A Lynch, T Morita, ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis 775, 55-68, 2014 | 111 | 2014 |
The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity SN Lauber, S Ali, NJ Gooderham Carcinogenesis 25 (12), 2509-2517, 2004 | 110 | 2004 |
Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-κB and IκB kinase-α in human colorectal cancer epithelial cells MP Charalambous, C Maihöfner, U Bhambra, T Lightfoot, NJ Gooderham British journal of cancer 88 (10), 1598-1604, 2003 | 110 | 2003 |
Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3 SAA Patel, U Bhambra, MP Charalambous, RM David, RJ Edwards, ... British journal of cancer 111 (12), 2287-2296, 2014 | 107 | 2014 |
Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phnylimidazo (4, 5-b) pyridine (PhIP) by human liver microsomes K Zhao, S Murray, DS Davies, AR Boobis, NJ Gooderham Carcinogenesis 15 (6), 1285-1288, 1994 | 106 | 1994 |
Measurement of MeIQx and DiMeIQx in fried beef by capillary column gas chromatography electron capture negative ion chemical ionisation mass spectrometry S Murray, NJ Gooderham, AR Boobis, DS Davies Carcinogenesis 9 (2), 321-325, 1988 | 103 | 1988 |