Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment R Kojima, D Bojar, G Rizzi, GCE Hamri, MD El-Baba, P Saxena, ... Nature communications 9 (1), 1305, 2018 | 566 | 2018 |
A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell Y Okamoto, R Kojima, F Schwizer, E Bartolami, T Heinisch, S Matile, ... Nature communications 9 (1), 1943, 2018 | 116 | 2018 |
Rational design and development of near‐infrared‐emitting firefly luciferins available in vivo R Kojima, H Takakura, T Ozawa, Y Tada, T Nagano, Y Urano Angewandte Chemie 125 (4), 1213-1217, 2013 | 105 | 2013 |
Novel theranostic agents for next-generation personalized medicine: small molecules, nanoparticles, and engineered mammalian cells R Kojima, D Aubel, M Fussenegger Current opinion in chemical biology 28, 29-38, 2015 | 82 | 2015 |
γ‐Glutamyltranspeptidase (GGT)‐activatable fluorescence probe for durable tumor imaging R Obara, M Kamiya, Y Tanaka, A Abe, R Kojima, T Kawaguchi, ... Angewandte Chemie International Edition 60 (4), 2125-2129, 2021 | 81 | 2021 |
Multicolor activatable Raman probes for simultaneous detection of plural enzyme activities H Fujioka, J Shou, R Kojima, Y Urano, Y Ozeki, M Kamiya Journal of the American Chemical Society 142 (49), 20701-20707, 2020 | 78 | 2020 |
Silicon rhodamine-based near-infrared fluorescent probe for γ-glutamyltransferase RJ Iwatate, M Kamiya, K Umezawa, H Kashima, M Nakadate, R Kojima, ... Bioconjugate chemistry 29 (2), 241-244, 2018 | 77 | 2018 |
Spontaneously blinking fluorophores based on nucleophilic addition/dissociation of intracellular glutathione for live-cell super-resolution imaging A Morozumi, M Kamiya, S Uno, K Umezawa, R Kojima, T Yoshihara, ... Journal of the American Chemical Society 142 (21), 9625-9633, 2020 | 76 | 2020 |
Fluorescence detection of prostate cancer by an activatable fluorescence probe for PSMA carboxypeptidase activity M Kawatani, K Yamamoto, D Yamada, M Kamiya, J Miyakawa, Y Miyama, ... Journal of the American Chemical Society 141 (26), 10409-10416, 2019 | 75 | 2019 |
Aminoluciferins as functional bioluminogenic substrates of firefly luciferase H Takakura, R Kojima, Y Urano, T Terai, K Hanaoka, T Nagano Chemistry–An Asian Journal 6 (7), 1800-1810, 2011 | 73 | 2011 |
New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT H Takakura, R Kojima, M Kamiya, E Kobayashi, T Komatsu, T Ueno, ... Journal of the American Chemical Society 137 (12), 4010-4013, 2015 | 71 | 2015 |
Development of a sensitive bioluminogenic probe for imaging highly reactive oxygen species in living rats R Kojima, H Takakura, M Kamiya, E Kobayashi, T Komatsu, T Ueno, ... Angewandte Chemie International Edition 54 (49), 14768-14771, 2015 | 60 | 2015 |
Activatable Photosensitizer for Targeted Ablation of lacZ-Positive Cells with Single-Cell Resolution M Chiba, M Kamiya, K Tsuda-Sakurai, Y Fujisawa, H Kosakamoto, ... ACS central science 5 (10), 1676-1681, 2019 | 58 | 2019 |
Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer K Miyata, Y Imai, S Hori, M Nishio, TM Loo, R Okada, L Yang, T Nakadai, ... Proceedings of the National Academy of Sciences, USA 118 (35), e2025647118, 2021 | 54 | 2021 |
Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation R Kojima, L Scheller, M Fussenegger Nature chemical biology 14 (1), 42-49, 2018 | 47 | 2018 |
Toward a world of theranostic medication: programming biological sentinel systems for therapeutic intervention R Kojima, D Aubel, M Fussenegger Advanced drug delivery reviews 105, 66-76, 2016 | 38 | 2016 |
Design strategy for germanium-rhodamine based pH-activatable near-infrared fluorescence probes suitable for biological applications Y Koide, R Kojima, K Hanaoka, K Numasawa, T Komatsu, T Nagano, ... Communications Chemistry 2 (1), 94, 2019 | 35 | 2019 |
Rapid and accurate visualization of breast tumors with a fluorescent probe targeting α-mannosidase 2C1 K Fujita, M Kamiya, T Yoshioka, A Ogasawara, R Hino, R Kojima, H Ueo, ... ACS central science 6 (12), 2217-2227, 2020 | 33 | 2020 |
Activatable fluorescent probes for hydrolase enzymes based on coumarin–hemicyanine hybrid fluorophores with large Stokes shifts H Fujioka, S Uno, M Kamiya, R Kojima, K Johnsson, Y Urano Chemical Communications 56 (42), 5617-5620, 2020 | 31 | 2020 |
Building sophisticated sensors of extracellular cues that enable mammalian cells to work as “doctors” in the body R Kojima, D Aubel, M Fussenegger Cellular and Molecular Life Sciences 77, 3567-3581, 2020 | 30 | 2020 |