| Structural basis of GPBAR activation and bile acid recognition F Yang, C Mao, L Guo, J Lin, Q Ming, P Xiao, X Wu, Q Shen, S Guo, ... Nature 587 (7834), 499-504, 2020 | 131 | 2020 |
| Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases K Kumpan, A Nathubhai, C Zhang, PJ Wood, MD Lloyd, AS Thompson, ... Bioorganic & Medicinal Chemistry 23 (13), 3013-3032, 2015 | 56 | 2015 |
| Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis J Cui, X Wang, X Li, X Wang, C Zhang, W Li, Y Zhang, H Gu, X Xie, F Nan, ... Cell Discovery 1 (1), 1-18, 2015 | 41 | 2015 |
| Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5H88Y Mutant Mice Y Yun, C Zhang, S Guo, X Liang, Y Lan, M Wang, N Zhuo, J Yin, H Liu, ... Journal of Medicinal Chemistry 64 (16), 12181-12199, 2021 | 19 | 2021 |
| Discovery of betulinic acid derivatives as potent intestinal farnesoid X receptor antagonists to ameliorate nonalcoholic steatohepatitis C Zhang, Y Liu, Y Wang, X Ge, T Jiao, J Yin, K Wang, C Li, S Guo, X Xie, ... Journal of Medicinal Chemistry 65 (19), 13452-13472, 2022 | 17 | 2022 |
| Synthetic analogues of betulinic acid as potent inhibitors of PS1/BACE1 interaction to reduce Aβ generation C Zhang, X Wang, J Cui, X Li, Y Zhang, X Wang, H Gu, W Li, X Xie, J Zhao, ... Chinese Journal of Chemistry 35 (1), 103-112, 2017 | 13 | 2017 |
| Synthesis and antitumor activity of lycogarubin C and lycogalic acid W Chen, H Hao, C Zhang, Y Shen Chinese Journal of Organic Chemistry 34 (4), 797, 2014 | 13 | 2014 |
| An efficient synthesis of the 1, 6-dioxaspiro [4.4] nonan-2-one motif of the immunosuppressive triterpenoid Phainanoid F CL Zhang, FJ Nan Tetrahedron Letters 58 (46), 4357-4359, 2017 | 11 | 2017 |
| A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation AA Basu, C Zhang, IA Riha, A Magassa, MA Campos, AG Caldwell, F Ko, ... Nature Chemical Biology 20 (12), 1608-1616, 2024 | 10 | 2024 |
| A CRISPR activation screen identifies FBXO22 as an E3 ligase supporting targeted protein degradation AA Basu, C Zhang, IA Riha, A Magassa, F Ko, X Zhang bioRxiv, 2023.09. 15.557708, 2023 | 3 | 2023 |
| A platform for mapping reactive cysteines within the immunopeptidome C Zhang, C Zhou, A Magassa, X Jin, D Fang, X Zhang Nature communications 15 (1), 9698, 2024 | 2 | 2024 |
| Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties N Zhuo, Y Yun, C Zhang, S Guo, J Yin, T Zhao, X Ge, M Gu, X Xie, F Nan Bioorganic Chemistry 144, 107132, 2024 | 2 | 2024 |
| Exploiting the DCAF16–SPIN4 interaction to identify DCAF16 ligands for PROTAC development IA Riha, MA Campos, X Jin, FY Wang, C Zhang, SF Dunne, BF Cravatt, ... RSC Medicinal Chemistry, 2025 | | 2025 |
| Discovery of DCAF16 binders for targeted protein degradation MA Campos, IA Riha, C Zhang, C Mozes, KA Scheidt, X Zhang ACS Chemical Biology, 2024 | | 2024 |
| Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation AA Basu, C Zhang, M Rouhimoghadam, A Vasudevan, JM Reitsma, ... bioRxiv, 2024.12. 03.626601, 2024 | | 2024 |
| Pentacyclic triterpene compound and preparation method therefor, and pharmaceutical composition and use thereof F Nan, X Xie, C Zhang, GUO Shimeng, Y Zhang, S Wang US Patent 11,192,916, 2021 | | 2021 |
Xiaoyu ZhangNorthwestern University在 northwestern.edu 的电子邮件经过验证
