Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 10824 | 2021 |
Resveratrol improves health and survival of mice on a high-calorie diet JA Baur, KJ Pearson, NL Price, HA Jamieson, C Lerin, A Kalra, ... Nature 444 (7117), 337-342, 2006 | 5375 | 2006 |
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan KJ Bitterman, HY Cohen, DW Lamming, S Lavu, JG Wood, RE Zipkin, ... Nature 425, 191-196, 2003 | 4851* | 2003 |
Therapeutic potential of resveratrol: the in vivo evidence JA Baur, DA Sinclair Nature reviews Drug discovery 5 (6), 493-506, 2006 | 4741 | 2006 |
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase A Brunet, LB Sweeney, JF Sturgill, KF Chua, PL Greer, Y Lin, H Tran, ... science 303 (5666), 2011-2015, 2004 | 3793 | 2004 |
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase HY Cohen, C Miller, KJ Bitterman, NR Wall, B Hekking, B Kessler, ... science 305 (5682), 390-392, 2004 | 2421 | 2004 |
Sirtuin activators mimic caloric restriction and delay ageing in metazoans JG Wood, B Rogina, S Lavu, K Howitz, SL Helfand, M Tatar, D Sinclair Nature 430 (7000), 686-689, 2004 | 2319 | 2004 |
Mammalian sirtuins: biological insights and disease relevance MC Haigis, DA Sinclair Annual Review of Pathology: Mechanisms of Disease 5, 253-295, 2010 | 2289 | 2010 |
Sirtuins in mammals: insights into their biological function S Michan, D Sinclair Biochemical Journal 404 (1), 1-13, 2007 | 2090 | 2007 |
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes JC Milne, PD Lambert, S Schenk, DP Carney, JJ Smith, DJ Gagne, L Jin, ... Nature 450 (7170), 712-716, 2007 | 2019 | 2007 |
Extrachromosomal rDNA circles—a cause of aging in yeast DA Sinclair, L Guarente Cell 91 (7), 1033-1042, 1997 | 1853 | 1997 |
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function NL Price, AP Gomes, AJY Ling, FV Duarte, A Martin-Montalvo, BJ North, ... Cell metabolism 15 (5), 675-690, 2012 | 1628 | 2012 |
The intersection between aging and cardiovascular disease BJ North, DA Sinclair Circulation research 110 (8), 1097-1108, 2012 | 1473 | 2012 |
Metformin improves healthspan and lifespan in mice A Martin-Montalvo, EM Mercken, SJ Mitchell, HH Palacios, PL Mote, ... Nature communications 4 (1), 2192, 2013 | 1454 | 2013 |
Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging AP Gomes, NL Price, AJY Ling, JJ Moslehi, MK Montgomery, L Rajman, ... Cell 155 (7), 1624-1638, 2013 | 1444 | 2013 |
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span KJ Pearson, JA Baur, KN Lewis, L Peshkin, NL Price, N Labinskyy, ... Cell metabolism 8 (2), 157-168, 2008 | 1370 | 2008 |
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1 KJ Bitterman, RM Anderson, HY Cohen, M Latorre-Esteves, DA Sinclair Journal of Biological Chemistry 277 (47), 45099-45107, 2002 | 1290 | 2002 |
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis D Kim, MD Nguyen, MM Dobbin, A Fischer, F Sananbenesi, JT Rodgers, ... The EMBO journal 26 (13), 3169-3179, 2007 | 1261 | 2007 |
Why does COVID-19 disproportionately affect older people? AL Mueller, MS McNamara, DA Sinclair Aging (albany NY) 12 (10), 9959, 2020 | 1146 | 2020 |
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival H Yang, T Yang, JA Baur, E Perez, T Matsui, JJ Carmona, DW Lamming, ... Cell 130 (6), 1095-1107, 2007 | 1109 | 2007 |