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Zhen Yang
Zhen Yang
Senior Scientist, Merck
在 merck.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME
Z Yang, K Kulkarni, W Zhu, M Hu
Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …, 2012
2122012
Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P‐glycoprotein
L Ye, T Wang, L Tang, W Liu, Z Yang, J Zhou, Z Zheng, Z Cai, M Hu, Z Liu
Journal of pharmaceutical sciences 100 (11), 5007-5017, 2011
1462011
Extended-duration MK-8591-eluting implant as a candidate for HIV treatment and prevention
SE Barrett, RS Teller, SP Forster, L Li, MA Mackey, D Skomski, Z Yang, ...
Antimicrobial agents and chemotherapy 62 (10), 10.1128/aac. 01058-18, 2018
1392018
Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC–MS/MS method: Application to an oral bioavailability study of …
Z Yang, W Zhu, S Gao, H Xu, B Wu, K Kulkarni, R Singh, L Tang, M Hu
Journal of pharmaceutical and biomedical analysis 53 (1), 81-89, 2010
962010
Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli
R Singh, MC Swick, KR Ledesma, Z Yang, M Hu, L Zechiedrich, VH Tam
Antimicrobial agents and chemotherapy 56 (4), 1680-1685, 2012
932012
Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides
H Xu, KH Kulkarni, R Singh, Z Yang, SWJ Wang, VH Tam, M Hu
Molecular pharmaceutics 6 (6), 1703-1715, 2009
902009
Breast cancer resistance protein (ABCG2) determines distribution of genistein phase II metabolites: reevaluation of the roles of ABCG2 in the disposition of genistein
Z Yang, W Zhu, S Gao, T Yin, W Jiang, M Hu
Drug Metabolism and Disposition 40 (10), 1883-1893, 2012
862012
Enhancement of Skin Permeation of Bufalin by Limonene via Reservoir Type Transdermal Patch: Formulation Design and Biopharmaceutical Evaluation
Z Yang, Y Teng, H Wang, H Hou
International Journal of Pharmaceutics, 2013
832013
The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected …
L Ye, X Yang, Z Yang, S Gao, T Yin, W Liu, F Wang, M Hu, Z Liu
Toxicology Letters 216 (2-3), 86-99, 2013
792013
Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora
Z Yang, JR Wang, T Niu, S Gao, T Yin, M You, ZH Jiang, M Hu
Drug Metabolism and Disposition 40 (8), 1538-1544, 2012
792012
Enhancement of oral bioavailability of 20 (S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms
Z Yang, S Gao, J Wang, T Yin, Y Teng, B Wu, M You, Z Jiang, M Hu
Drug Metabolism and Disposition 39 (10), 1866-1872, 2011
772011
Bioavailability challenges associated with development of saponins as therapeutic and chemopreventive agents
S Gao, S Basu, Z Yang, A Deb, M Hu
Current drug targets 13 (14), 1885-1899, 2012
752012
Sensitive and robust UPLC–MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide
W Liu, Z Zheng, X Liu, S Gao, L Ye, Z Yang, M Hu, Z Liu
Journal of Pharmaceutical and Biomedical Analysis 54 (5), 1157-1162, 2011
642011
Biopharmaceutical and pharmacokinetic characterization of matrine as determined by a sensitive and robust UPLC–MS/MS method
Z Yang, S Gao, T Yin, KH Kulkarni, Y Teng, M You, M Hu
Journal of pharmaceutical and biomedical analysis 51 (5), 1120-1127, 2010
642010
Bioactivity and Bioavailability of Ginsenosides are Dependent on the Glycosidase Activities of the A/J Mouse Intestinal Microbiome Defined by Pyrosequencing.
T Niu, DL Smith, Z Yang, S Gao, T Yin, ZH Jiang, M You, RA Gibbs, ...
Pharmaceutical research, 2012
622012
Ginsenoside Rb1 Directly Scavenges Hydroxyl Radical and Hypochlorous Acid.
JM Lü, S Weakley, Z Yang, M Hu, Q Yao, C Chen
Current pharmaceutical design, 2012
522012
Rapid and simultaneous determination of multiple classes of abused drugs and metabolites in human urine by a robust LC‐MS/MS method–application to urine drug testing in pain …
J Wang, Z Yang, J Lechago
Biomedical Chromatography 27 (11), 1463-1480, 2013
432013
Preparative isolation of bufalin and cinobufagin from Chinese traditional medicine ChanSu
Z Yang, H Luo, H Wang, H Hou
Journal of chromatographic science 46 (1), 81-85, 2008
432008
Development of a novel oral cavity compartmental absorption and transit model for sublingual administration: illustration with zolpidem
B Xia, Z Yang, H Zhou, V Lukacova, W Zhu, M Milewski, F Kesisoglou
The AAPS journal 17, 631-642, 2015
342015
Validated LC–MS/MS method for the determination of maackiain and its sulfate and glucuronide in blood: Application to pharmacokinetic and disposition studies
S Gao, Z Yang, T Yin, M You, M Hu
Journal of pharmaceutical and biomedical analysis 55 (2), 288-293, 2011
282011
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