| The engineering of an orally active conotoxin for the treatment of neuropathic pain RJ Clark, J Jensen, DJ Craik, ST Nevin, BP Callaghan, DJ Adams Angewandte Chemie International Edition 49 (37), 6545-6548, 2010 | 355 | 2010 |
| Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone KJ Rosengren, RJ Clark, NL Daly, U Göransson, A Jones, DJ Craik Journal of the American Chemical Society 125 (41), 12464-12474, 2003 | 294 | 2003 |
| Engineering stable peptide toxins by means of backbone cyclization: stabilization of the α-conotoxin MII RJ Clark, H Fischer, L Dempster, NL Daly, KJ Rosengren, ST Nevin, ... Proceedings of the National Academy of Sciences 102 (39), 13767-13772, 2005 | 290 | 2005 |
| Helminth immunomodulation in autoimmune disease TB Smallwood, PR Giacomin, A Loukas, JP Mulvenna, RJ Clark, JJ Miles Frontiers in immunology 8, 453, 2017 | 245 | 2017 |
| Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides S Gunasekera, FM Foley, RJ Clark, L Sando, LJ Fabri, DJ Craik, NL Daly Journal of medicinal chemistry 51 (24), 7697-7704, 2008 | 240 | 2008 |
| Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds LY Chan, S Gunasekera, ST Henriques, NF Worth, SJ Le, RJ Clark, ... Blood, The Journal of the American Society of Hematology 118 (25), 6709-6717, 2011 | 230 | 2011 |
| Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design RJ Clark, NL Daly, DJ Craik Biochemical Journal 394 (1), 85-93, 2006 | 195 | 2006 |
| Analgesic α-conotoxins Vc1. 1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation B Callaghan, A Haythornthwaite, G Berecki, RJ Clark, DJ Craik, ... Journal of Neuroscience 28 (43), 10943-10951, 2008 | 193 | 2008 |
| The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1. 1 RJ Clark, H Fischer, ST Nevin, DJ Adams, DJ Craik Journal of Biological Chemistry 281 (32), 23254-23263, 2006 | 170 | 2006 |
| The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity A Herrmann, R Burman, JS Mylne, G Karlsson, J Gullbo, DJ Craik, ... Phytochemistry 69 (4), 939-952, 2008 | 168 | 2008 |
| Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins JL Dutton, RF Renda, C Waine, RJ Clark, NL Daly, CV Jennings, ... Journal of Biological Chemistry 279 (45), 46858-46867, 2004 | 160 | 2004 |
| A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins CW Gruber, M Cemazar, RJ Clark, T Horibe, RF Renda, MA Anderson, ... Journal of Biological Chemistry 282 (28), 20435-20446, 2007 | 156 | 2007 |
| Disulfide folding pathways of cystine knot proteins: tying the knot within the circular backbone of the cyclotides NL Daly, RJ Clark, DJ Craik Journal of Biological Chemistry 278 (8), 6314-6322, 2003 | 143 | 2003 |
| Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif NL Daly, RJ Clark, MR Plan, DJ Craik Biochemical Journal 393 (3), 619-626, 2006 | 138 | 2006 |
| Linearization of a Naturally Occurring Circular Protein Maintains Structure but Eliminates Hemolytic Activity†,‡ DG Barry, NL Daly, RJ Clark, L Sando, DJ Craik Biochemistry 42 (22), 6688-6695, 2003 | 138 | 2003 |
| Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? ST Nevin, RJ Clark, H Klimis, MJ Christie, DJ Craik, DJ Adams Molecular Pharmacology 72 (6), 1406-1410, 2007 | 129 | 2007 |
| Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity YH Huang, ML Colgrave, RJ Clark, AC Kotze, DJ Craik Journal of Biological Chemistry 285 (14), 10797-10805, 2010 | 125 | 2010 |
| The Cyclotide Fingerprint in Oldenlandia affinis: Elucidation of Chemically Modified, Linear and Novel Macrocyclic Peptides MRR Plan, U Göransson, RJ Clark, NL Daly, ML Colgrave, DJ Craik ChemBioChem 8 (9), 1001-1011, 2007 | 122 | 2007 |
| Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy M Akcan, MR Stroud, SJ Hansen, RJ Clark, NL Daly, DJ Craik, JM Olson Journal of medicinal chemistry 54 (3), 782-787, 2011 | 119 | 2011 |
| Invited reviewnative chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins RJ Clark, DJ Craik Peptide Science 94 (4), 414-422, 2010 | 119 | 2010 |
David J CraikUniversity of Queensland在 imb.uq.edu.au 的电子邮件经过验证
