Restoring metabolism of myeloid cells reverses cognitive decline in ageing PS Minhas, A Latif-Hernandez, MR McReynolds, AS Durairaj, Q Wang, ... Nature 590 (7844), 122-128, 2021 | 321 | 2021 |
Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition D Shah, J Praet, AL Hernandez, C Höfling, C Anckaerts, F Bard, ... Alzheimer's & dementia 12 (9), 964-976, 2016 | 88 | 2016 |
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL− G− F mice before prominent plaque deposition A Latif-Hernandez, D Shah, K Craessaerts, T Saido, T Saito, ... Behavioural brain research 364, 431-441, 2019 | 85 | 2019 |
Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice D Shah, A Latif-Hernandez, B De Strooper, T Saito, T Saido, M Verhoye, ... Scientific reports 8 (1), 6264, 2018 | 58 | 2018 |
Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity A Latif-Hernandez, D Shah, T Ahmed, AC Lo, Z Callaerts-Vegh, ... Scientific reports 6 (1), 36489, 2016 | 55 | 2016 |
The two faces of synaptic failure in AppNL-G-F knock-in mice A Latif-Hernandez, V Sabanov, T Ahmed, K Craessaerts, T Saito, T Saido, ... Alzheimer's research & therapy 12, 1-15, 2020 | 40 | 2020 |
Separate Ionotropic and metabotropic glutamate receptor functions in Depotentiation vs. LTP: a distinct role for Group1 mGluR subtypes and NMDARs A Latif-Hernandez, E Faldini, T Ahmed, D Balschun Frontiers in Cellular Neuroscience 10, 252, 2016 | 22 | 2016 |
Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning CA Iweka, E Seigneur, AL Hernandez, SH Paredes, M Cabrera, E Blacher, ... Journal of Neuroinflammation 20 (1), 48, 2023 | 12 | 2023 |
Commentary: APP as a Mediator of the Synapse Pathology in Alzheimer's Disease A Schreurs, A Latif-Hernandez, A Uwineza Frontiers in Cellular Neuroscience 12, 150, 2018 | 4 | 2018 |
Synaptic deficits in prefrontal cortex and hippocampus of young APP-V717I x TAU-P301L and TAU-P301L mice A Schreurs, A Latif-Hernandez, T Ahmed, F Van Leuven, D Balschun AD/PD-13th International Conference on Alzheimer's & Parkinson's Diseases …, 2017 | 2 | 2017 |
Elucidating emerging therapeutics: P75 receptor modulation reverts tauopathy associated alterations in synapse‐relevant gene expression signatures: Preclinical small‐molecule … A Latif‐Hernandez, PM Losada, T Yang, KC Tran, H Liu, B Lehallier, ... Alzheimer's & Dementia 16, e045764, 2020 | 1 | 2020 |
Medial prefrontal cortex ablation results in impaired spatial memory and hippocampal long-term potentiation with increased functional connectivity in vivo A Latif-Hernandez, D Shah, A Lo, T Ahmed, Z Callaerts-Vegh, J De Wit, ... Front. Neurosci. Conference Abstract: 11th National Congress of the Belgian …, 2015 | 1 | 2015 |
A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity‐dependent synaptic and microglial transcriptomic changes in a late‐stage Alzheimer … A Latif‐Hernandez, T Yang, R Raymond‐Butler III, PM Losada, PS Minhas, ... Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024 | | 2024 |
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies PS Minhas, JR Jones, A Latif-Hernandez, YS Sugiura, A Durairaj, ... bioRxiv, 2024.06. 23.598940, 2024 | | 2024 |
Neuronal stimulation‐regulated RNA splicing defects in tauopathies are corrected by treatment with a p75 NTR modulator A Latif‐Hernandez, P Moran‐Losada, T Yang, H White, KC Tran, H Liu, ... Alzheimer's & Dementia 19, e080548, 2023 | | 2023 |
p75NTR modulation counteracts alterations in neuronal and glial activity‐dependent profiles of gene co‐expression networks in tauopathy mice A Latif‐Hernandez, P Moran‐Losada, T Yang, RRB III, KC Tran, H Liu, ... Alzheimer's & Dementia 18, e066948, 2022 | | 2022 |
Drug Development: Translational discoveries from nonhuman research A Latif-Hernandez, C Tallon Alzheimer's Association International Conference, 2022 | | 2022 |
Activity‐dependent dysfunctional gene expression patterns are normalized by in vivo treatment of late‐stage Aβ pathology mice with a TrkB/C small molecule ligand A Latif‐Hernandez, P Moran‐Losada, T Yang, KC Tran, H Liu, ... Alzheimer's & Dementia 17, e055861, 2021 | | 2021 |
P3‐212: A SMALL MOLECULE TRKB/TRKC NEUROTROPHIN RECEPTOR CO‐ACTIVATOR PREVENTS SYNAPTIC IMPAIRMENT IN AN AD MOUSE MODEL A Latif-Hernandez, T Yang, KC Tran, H Liu, SM Massa, FM Longo Alzheimer's & Dementia 15, P1011-P1011, 2019 | | 2019 |
Early hippocampal and prefrontal synaptic deficits without significant amyloid and tau aggregation in an APPxTau mouse model A Schreurs, A Latif Hernandez, U Zeitschel, K Krautwald, J Stieler, ... AD/PD-International Conference on Alzheimer's\& Parkinson's Diseases, Date …, 2019 | | 2019 |