| Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains L Guo, HJ Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ... Cell 173 (3), 677-692. e20, 2018 | 438 | 2018 |
| Loss of dynamic RNA interaction and aberrant phase separation induced by two distinct types of ALS/FTD-Linked FUS mutations AG Niaki, J Sarkar, X Cai, K Rhine, V Vidaurre, B Guy, M Hurst, JC Lee, ... Molecular cell 77 (1), 82-94. e4, 2020 | 139 | 2020 |
| Higher-order organization of biomolecular condensates CM Fare, A Villani, LE Drake, J Shorter Open biology 11 (6), 210137, 2021 | 117 | 2021 |
| Nuclear import receptors directly bind to arginine-rich dipeptide repeat proteins and suppress their pathological interactions S Hutten, S Usluer, B Bourgeois, F Simonetti, HM Odeh, CM Fare, ... Cell reports 33 (12), 2020 | 81 | 2020 |
| ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS K Rhine, MA Makurath, J Liu, S Skanchy, C Lopez, KF Catalan, Y Ma, ... Molecular cell, 2020 | 79 | 2020 |
| Therapeutic dissolution of aberrant phases by nuclear-import receptors L Guo, CM Fare, J Shorter Trends in cell biology 29 (4), 308-322, 2019 | 71 | 2019 |
| Poly (ADP-ribose) drives condensation of FUS via a transient interaction K Rhine, M Dasovich, J Yoniles, M Badiee, S Skanchy, LR Ganser, Y Ge, ... Molecular cell 82 (5), 969-985. e11, 2022 | 49 | 2022 |
| Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation H Shen, A Yanas, MC Owens, C Zhang, C Fritsch, CM Fare, KE Copley, ... Molecular cell 82 (14), 2588-2603. e9, 2022 | 47 | 2022 |
| Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation D Beijer, HJ Kim, L Guo, K O’Donovan, I Mademan, T Deconinck, ... JCI insight 6 (14), 2021 | 47 | 2021 |
| Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy HJ Kim, P Mohassel, S Donkervoort, L Guo, K O’donovan, M Coughlin, ... Nature communications 13 (1), 2306, 2022 | 25 | 2022 |
| (Dis) Solving the problem of aberrant protein states CM Fare, J Shorter Disease Models & Mechanisms 14 (5), dmm048983, 2021 | 24 | 2021 |
| Nuclear-import receptors counter deleterious phase transitions in neurodegenerative disease HM Odeh, CM Fare, J Shorter Journal of molecular biology 434 (1), 167220, 2022 | 18 | 2022 |
| A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity CM Fare, K Rhine, A Lam, S Myong, J Shorter Journal of Biological Chemistry 299 (2), 2023 | 13* | 2023 |
| Nuclear pore dysfunction and disease: a complex opportunity CM Fare, JD Rothstein Nucleus 15 (1), 2314297, 2024 | 3 | 2024 |
| Open access: a role for p53 in c9ALS/FTD? CM Fare, J Shorter Trends in Genetics 37 (5), 404-406, 2021 | 2 | 2021 |
| ENGINEERING KAPβ2 TO DISAGGREGATE DISEASE-ASSOCIATED PROTEINS C Fare University of Pennsylvania, 2022 | | 2022 |
James ShorterProfessor of Biochemistry and Biophysics, University of Pennsylvania在 pennmedicine.upenn.edu 的电子邮件经过验证
