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Epigenetic therapy inhibits metastases by disrupting premetastatic niches Z Lu, J Zou, S Li, MJ Topper, Y Tao, H Zhang, X Jiao, W Xie, X Kong, ... Nature 579 (7798), 284-290, 2020 | 273 | 2020 |
Aging-like spontaneous epigenetic silencing facilitates Wnt activation, stemness, and BrafV600E-induced tumorigenesis Y Tao, B Kang, DA Petkovich, YR Bhandari, J In, G Stein-O'Brien, X Kong, ... Cancer cell 35 (2), 315-328. e6, 2019 | 137 | 2019 |
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5 KB Harikumar, JW Yester, MJ Surace, C Oyeniran, MM Price, WC Huang, ... Nature immunology 15 (3), 231-238, 2014 | 133 | 2014 |
Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2 X Kong, L Chen, L Jiao, X Jiang, F Lian, J Lu, K Zhu, D Du, J Liu, H Ding, ... Journal of medicinal chemistry 57 (22), 9512-9521, 2014 | 115 | 2014 |
Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA F Sun, H Liang, X Kong, S Xie, H Cho, X Deng, Q Ji, H Zhang, S Alvarez, ... Proceedings of the National Academy of Sciences 109 (23), 9095-9100, 2012 | 113 | 2012 |
Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and oncogenic properties X Kong, J Chen, W Xie, SM Brown, Y Cai, K Wu, D Fan, Y Nie, ... Cancer Cell 35 (4), 633-648. e7, 2019 | 109 | 2019 |
DNA methylation patterns separate senescence from transformation potential and indicate cancer risk W Xie, I Kagiampakis, L Pan, YW Zhang, L Murphy, Y Tao, X Kong, ... Cancer cell 33 (2), 309-321. e5, 2018 | 108 | 2018 |
Molecular basis of NDM-1, a new antibiotic resistance determinant Z Liang, L Li, Y Wang, L Chen, X Kong, Y Hong, L Lan, M Zheng, ... PLoS One 6 (8), e23606, 2011 | 86 | 2011 |
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells Y Cai, HC Tsai, RWC Yen, YW Zhang, X Kong, W Wang, L Xia, SB Baylin Genome research 27 (4), 533-544, 2017 | 84 | 2017 |
Salvianolic acid A, a novel matrix metalloproteinase-9 inhibitor, prevents cardiac remodeling in spontaneously hypertensive rats B Jiang, D Li, Y Deng, F Teng, J Chen, S Xue, X Kong, C Luo, X Shen, ... PloS one 8 (3), e59621, 2013 | 83 | 2013 |
Catalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational study X Kong, S Ouyang, Z Liang, J Lu, L Chen, B Shen, D Li, M Zheng, KK Li, ... PLoS One 6 (9), e25444, 2011 | 59 | 2011 |
An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated … CY Kuo, X Li, XQ Kong, C Luo, CC Chang, Y Chung, HM Shih, KK Li, ... Journal of Biological Chemistry 289 (30), 20757-20772, 2014 | 57 | 2014 |
Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease F Ye, J Zhang, H Liu, R Hilgenfeld, R Zhang, X Kong, L Li, J Lu, X Zhang, ... Journal of Biological Chemistry 288 (24), 17643-17653, 2013 | 56 | 2013 |
Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction X Zhang, S Ouyang, X Kong, Z Liang, J Lu, K Zhu, D Zhao, M Zheng, ... The Journal of Physical Chemistry B 118 (8), 2009-2019, 2014 | 45 | 2014 |
Identification and synthesis of N′-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase Z Liang, D Zhang, J Ai, L Chen, H Wang, X Kong, M Zheng, H Liu, C Luo, ... Bioorganic & medicinal chemistry letters 21 (12), 3749-3754, 2011 | 45 | 2011 |
Investigation of the acetylation mechanism by GCN5 histone acetyltransferase J Jiang, J Lu, D Lu, Z Liang, L Li, S Ouyang, X Kong, H Jiang, B Shen, ... PLoS One 7 (5), e36660, 2012 | 44 | 2012 |
A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-β-lactamase-1 K Zhu, J Lu, Z Liang, X Kong, F Ye, L Jin, H Geng, Y Chen, M Zheng, ... Journal of computer-aided molecular design 27, 247-256, 2013 | 43 | 2013 |
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Biochemical studies and molecular dynamic simulations reveal the molecular basis of conformational changes in DNA methyltransferase-1 F Ye, X Kong, H Zhang, Y Liu, Z Shao, J Jin, Y Cai, R Zhang, L Li, ... ACS chemical biology 13 (3), 772-781, 2018 | 32 | 2018 |