Structure, function, and allosteric modulation of NMDA receptors KB Hansen, F Yi, RE Perszyk, H Furukawa, LP Wollmuth, AJ Gibb, ... Journal of General Physiology 150 (8), 1081-1105, 2018 | 511 | 2018 |
Structure, function, and pharmacology of glutamate receptor ion channels KB Hansen, LP Wollmuth, D Bowie, H Furukawa, FS Menniti, ... Pharmacological Reviews 73 (4), 298-487, 2021 | 320 | 2021 |
NMDA receptors in the central nervous system KB Hansen, F Yi, RE Perszyk, FS Menniti, SF Traynelis NMDA Receptors, 1-80, 2017 | 162 | 2017 |
GluN2D-containing N-methyl-d-aspartate receptors mediate synaptic transmission in hippocampal interneurons and regulate interneuron activity RE Perszyk, JO DiRaddo, KL Strong, CM Low, KK Ogden, A Khatri, ... Molecular pharmacology 90 (6), 689-702, 2016 | 96 | 2016 |
Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors KB Hansen, N Tajima, R Risgaard, RE Perszyk, L Jørgensen, KM Vance, ... Molecular pharmacology 84 (1), 114-127, 2013 | 86 | 2013 |
An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups R Perszyk, BM Katzman, H Kusumoto, SA Kell, MP Epplin, YA Tahirovic, ... Elife 7, e34711, 2018 | 39 | 2018 |
Biased modulators of NMDA receptors control channel opening and ion selectivity RE Perszyk, SA Swanger, C Shelley, A Khatri, G Fernandez-Cuervo, ... Nature chemical biology 16 (2), 188-196, 2020 | 34 | 2020 |
Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors LM DePoy, RE Perszyk, KS Zimmermann, AJ Koleske, SL Gourley Frontiers in pharmacology 5, 228, 2014 | 26 | 2014 |
Hodgkin–Huxley–Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif RE Perszyk, SJ Myers, H Yuan, AJ Gibb, H Furukawa, AI Sobolevsky, ... The Journal of physiology 598 (15), 3071-3083, 2020 | 23 | 2020 |
A novel class of negative allosteric modulators of NMDA receptor function BM Katzman, RE Perszyk, H Yuan, YA Tahirovic, AE Sotimehin, ... Bioorganic & medicinal chemistry letters 25 (23), 5583-5588, 2015 | 20 | 2015 |
Three-dimensional missense tolerance ratio analysis RE Perszyk, AS Kristensen, P Lyuboslavsky, SF Traynelis Genome Research 31 (8), 1447-1461, 2021 | 19 | 2021 |
Opportunities for precision treatment of GRIN2A and GRIN2B gain-of-function variants in triheteromeric NMDA receptors W Han, H Yuan, JP Allen, S Kim, GH Shaulsky, RE Perszyk, SF Traynelis, ... Journal of Pharmacology and Experimental Therapeutics, 2022 | 11 | 2022 |
The Negative Allosteric Modulator EU1794-4 Reduces Single-Channel Conductance and Ca2+ Permeability of GluN1/GluN2A N-Methyl-d-Aspartate Receptors RE Perszyk, Z Zheng, TG Banke, J Zhang, L Xie, MJ McDaniel, ... Molecular Pharmacology 99 (5), 399-411, 2021 | 11 | 2021 |
Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-d-aspartate Receptors KL Strong, MP Epplin, KK Ogden, PB Burger, TM Kaiser, TJ Wilding, ... ACS chemical neuroscience 12 (1), 79-98, 2020 | 11 | 2020 |
Automated intracellular pharmacological electrophysiology for ligand-gated ionotropic receptor and pharmacology screening RE Perszyk, MC Yip, OL McConnell, ET Wang, A Jenkins, SF Traynelis, ... Molecular Pharmacology 100 (1), 73-82, 2021 | 5 | 2021 |
The GluN2A subunit of the NMDA receptor modulates the rate of functional maturation in parvalbumin-positive interneurons CR Camp, L Shapiro, A Vlachos, RE Perszyk, N Shariatzadeh, J White, ... bioRxiv, 2021 | | 2021 |
Hodgkin-huxley-katz prize lecture: genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif (vol 598, pg 3071, 2020) RE Perszyk, SJ Myers, H Yuan, AJ Gibb, H Furukawa, A Sobolevsky, ... JOURNAL OF PHYSIOLOGY-LONDON 598 (21), 4995-4995, 2020 | | 2020 |
Channel Open Probability Controls Allosteric Modulation of Potency and Efficacy RE Perszyk, KK Ogden, KL Strong, DC Liotta, SF Traynelis Biophysical Journal 112 (3), 420a-421a, 2017 | | 2017 |
A conserved Asparagine Between Loops A and E of Anion Ligand-Gated Channels is Critical for Gaba (A) Receptor Function REA Perszyk, CA Wiliams, A Jenkins Biophysical Journal 100 (3), 271a, 2011 | | 2011 |