| Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A VG Sankaran, TF Menne, J Xu, TE Akie, G Lettre, B Van Handel, ... Science 322 (5909), 1839-1842, 2008 | 1049 | 2008 |
| An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level DE Bauer, SC Kamran, S Lessard, J Xu, Y Fujiwara, C Lin, Z Shao, ... Science 342 (6155), 253-257, 2013 | 685 | 2013 |
| Developmental and species-divergent globin switching are driven by BCL11A VG Sankaran, J Xu, T Ragoczy, GC Ippolito, CR Walkley, SD Maika, ... Nature 460 (7259), 1093-1097, 2009 | 475 | 2009 |
| Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6 J Xu, VG Sankaran, M Ni, TF Menne, RV Puram, W Kim, SH Orkin Genes & development 24 (8), 783-798, 2010 | 469 | 2010 |
| Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch N Liu, VV Hargreaves, Q Zhu, JV Kurland, J Hong, W Kim, F Sher, ... Cell 173 (2), 430-442. e17, 2018 | 410 | 2018 |
| Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing J Xu, C Peng, VG Sankaran, Z Shao, EB Esrick, BG Chong, GC Ippolito, ... Science 334 (6058), 993-996, 2011 | 371 | 2011 |
| Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin T Masuda, X Wang, M Maeda, MC Canver, F Sher, APW Funnell, C Fisher, ... Science 351 (6270), 285-289, 2016 | 343 | 2016 |
| Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner H Xie, J Xu, JH Hsu, M Nguyen, Y Fujiwara, C Peng, SH Orkin Cell stem cell 14 (1), 68-80, 2014 | 328 | 2014 |
| In situ capture of chromatin interactions by biotinylated dCas9 X Liu, Y Zhang, Y Chen, M Li, F Zhou, K Li, H Cao, M Ni, Y Liu, Z Gu, ... Cell 170 (5), 1028-1043. e19, 2017 | 298 | 2017 |
| The mitochondrial respiratory chain is essential for haematopoietic stem cell function E Ansó, SE Weinberg, LP Diebold, BJ Thompson, S Malinge, ... Nature cell biology 19 (6), 614-625, 2017 | 278 | 2017 |
| Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire G Guo, S Luc, E Marco, TW Lin, C Peng, MA Kerenyi, S Beyaz, W Kim, ... Cell stem cell 13 (4), 492-505, 2013 | 276 | 2013 |
| CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells J Kim, Z Hu, L Cai, K Li, E Choi, B Faubert, D Bezwada, ... Nature 546 (7656), 168-172, 2017 | 271 | 2017 |
| Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production Y Li, V Esain, L Teng, J Xu, W Kwan, IM Frost, AD Yzaguirre, X Cai, ... Genes & development 28 (23), 2597-2612, 2014 | 264 | 2014 |
| Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A J Xu, DE Bauer, MA Kerenyi, TD Vo, S Hou, YJ Hsu, H Yao, JJ Trowbridge, ... Proceedings of the National Academy of Sciences 110 (16), 6518-6523, 2013 | 263 | 2013 |
| Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis J Yu, M Ni, J Xu, H Zhang, B Gao, J Gu, J Chen, L Zhang, M Wu, S Zhen, ... BMC cancer 2, 1-14, 2002 | 260 | 2002 |
| Advances in the understanding of haemoglobin switching VG Sankaran, J Xu, SH Orkin British journal of haematology 149 (2), 181-194, 2010 | 258 | 2010 |
| Dynamic control of enhancer repertoires drives lineage and stage-specific transcription during hematopoiesis J Huang, X Liu, D Li, Z Shao, H Cao, Y Zhang, E Trompouki, TV Bowman, ... Developmental cell 36 (1), 9-23, 2016 | 237 | 2016 |
| Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis J Xu, Z Shao, K Glass, DE Bauer, L Pinello, B Van Handel, S Hou, ... Developmental cell 23 (4), 796-811, 2012 | 234 | 2012 |
| Dissecting super-enhancer hierarchy based on chromatin interactions J Huang, K Li, W Cai, X Liu, Y Zhang, SH Orkin, J Xu, GC Yuan Nature communications 9 (1), 943, 2018 | 223 | 2018 |
| Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells J Xu, JA Watts, SD Pope, P Gadue, M Kamps, K Plath, KS Zaret, ST Smale Genes & development 23 (24), 2824-2838, 2009 | 205 | 2009 |
Stuart Orkin在 dfci.harvard.edu 的电子邮件经过验证
