A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models Y Zhou, P Castonguay, EH Sidhom, AR Clark, M Dvela-Levitt, S Kim, ... Science 358 (6368), 1332-1336, 2017 | 145 | 2017 |
Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy M Dvela-Levitt, M Kost-Alimova, M Emani, E Kohnert, R Thompson, ... Cell 178 (3), 521-535. e23, 2019 | 144 | 2019 |
Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies N Wieder, A Greka Pediatric Nephrology 31, 1047-1054, 2016 | 54 | 2016 |
Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease EH Sidhom, C Kim, M Kost-Alimova, MT Ting, K Keller, J Avila-Pacheco, ... The Journal of clinical investigation 131 (5), 2021 | 31 | 2021 |
Exact stochastic simulation of a calcium microdomain reveals the impact of Ca2+ fluctuations on IP3R gating N Wieder, R Fink, F von Wegner Biophysical journal 108 (3), 557-567, 2015 | 25 | 2015 |
GDC-0879, a BRAFV600E inhibitor, protects kidney podocytes from death J Sieber, N Wieder, A Clark, M Reitberger, S Matan, J Schoenfelder, ... Cell chemical biology 25 (2), 175-184. e4, 2018 | 21 | 2018 |
Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress J Sieber, N Wieder, M Ostrosky-Frid, M Dvela-Levitt, O Aygün, ND Udeshi, ... Journal of Biological Chemistry 292 (46), 18878-18885, 2017 | 13 | 2017 |
Microdomain calcium fluctuations as a colored noise process F von Wegner, N Wieder, RHA Fink Frontiers in genetics 5, 111517, 2014 | 11 | 2014 |
Exact and approximate stochastic simulation of intracellular calcium dynamics N Wieder, RHA Fink, F von Wegner BioMed Research International 2011, 2011 | 11 | 2011 |
Simulation strategies for calcium microdomains and calcium-regulated calcium channels F von Wegner, N Wieder, RHA Fink Calcium Signaling, 553-567, 2012 | 6 | 2012 |
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity N Wieder, JC Fried, C Kim, EH Sidhom, MR Brown, JL Marshall, ... Cell metabolism 35 (5), 887-905. e11, 2023 | 5 | 2023 |
Simulation strategies for calcium microdomains and calcium noise N Wieder, RHA Fink, F von Wegner Calcium Signaling, 771-797, 2020 | 4 | 2020 |
Pearls & Oy-sters: A cause of intractable vomiting LLL Yeo, N Wieder, AS Wang, E Ting, R Rathakrishnan, D Soon Neurology 83 (15), e141-e144, 2014 | 1 | 2014 |
Compositions, methods and uses for free fatty acid screening of cells at scale A Greka, N Wieder, J Coraor US Patent App. 17/641,683, 2022 | | 2022 |
Fully Stochastic Simulation of Calcium Microdomains NW Wieder | | 2016 |